1dw3

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[[Image:1dw3.gif|left|200px]]
 
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==STRUCTURE OF A REDUCED OXYGEN BINDING CYTOCHROME C==
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The line below this paragraph, containing "STRUCTURE_1dw3", creates the "Structure Box" on the page.
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<StructureSection load='1dw3' size='340' side='right'caption='[[1dw3]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1dw3]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Cereibacter_sphaeroides Cereibacter sphaeroides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DW3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DW3 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEC:HEME+C'>HEC</scene></td></tr>
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{{STRUCTURE_1dw3| PDB=1dw3 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dw3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dw3 OCA], [https://pdbe.org/1dw3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dw3 RCSB], [https://www.ebi.ac.uk/pdbsum/1dw3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dw3 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SHP_CERS4 SHP_CERS4] High-spin cytochrome. Transiently bind oxygen during autoxidation, which occurs with a half-life of 3 min with a 4-fold excess of O(2). Also binds carbon monoxide, azide and cyanide.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dw/1dw3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dw3 ConSurf].
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<div style="clear:both"></div>
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'''STRUCTURE OF A REDUCED OXYGEN BINDING CYTOCHROME C'''
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==See Also==
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*[[Cytochrome C 3D structures|Cytochrome C 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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The photosynthetic bacterium Rhodobacter sphaeroides produces a heme protein (SHP), which is an unusual c-type cytochrome capable of transiently binding oxygen during autooxidation. Similar proteins have not only been observed in other photosynthetic bacteria but also in the obligate methylotroph Methylophilus methylotrophus and the metal reducing bacterium Shewanella putrefaciens. A three-dimensional structure of SHP was derived using the multiple isomorphous replacement phasing method. Besides a model for the oxidized state (to 1.82 A resolution), models for the reduced state (2.1 A resolution), the oxidized molecule liganded with cyanide (1. 90 A resolution), and the reduced molecule liganded with nitric oxide (2.20 A resolution) could be derived. The SHP structure represents a new variation of the class I cytochrome c fold. The oxidized state reveals a novel sixth heme ligand, Asn(88), which moves away from the iron upon reduction or when small molecules bind. The distal side of the heme has a striking resemblance to other heme proteins that bind gaseous compounds. In SHP the liberated amide group of Asn(88) stabilizes solvent-shielded ligands through a hydrogen bond.
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[[Category: Cereibacter sphaeroides]]
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[[Category: Large Structures]]
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==About this Structure==
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[[Category: Backers K]]
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1DW3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rhodobacter_sphaeroides Rhodobacter sphaeroides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DW3 OCA].
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[[Category: Cusanovich MA]]
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[[Category: Hagen WR]]
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==Reference==
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[[Category: Leys D]]
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Crystal structures of an oxygen-binding cytochrome c from Rhodobacter sphaeroides., Leys D, Backers K, Meyer TE, Hagen WR, Cusanovich MA, Van Beeumen JJ, J Biol Chem. 2000 May 26;275(21):16050-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10821858 10821858]
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[[Category: Meyer TE]]
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[[Category: Rhodobacter sphaeroides]]
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[[Category: Van Beeumen JJ]]
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[[Category: Single protein]]
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[[Category: Backers, K.]]
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[[Category: Beeumen, J J.Van.]]
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[[Category: Cusanovich, M A.]]
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[[Category: Hagen, W R.]]
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[[Category: Leys, D.]]
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[[Category: Meyer, T E.]]
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[[Category: Asparagine ligation]]
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[[Category: Cytochrome c]]
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[[Category: Disulfide bridge]]
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[[Category: Reduced]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:21:03 2008''
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Current revision

STRUCTURE OF A REDUCED OXYGEN BINDING CYTOCHROME C

PDB ID 1dw3

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