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1dgn
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==SOLUTION STRUCTURE OF ICEBERG, AN INHIBITOR OF INTERLEUKIN-1BETA GENERATION== | ==SOLUTION STRUCTURE OF ICEBERG, AN INHIBITOR OF INTERLEUKIN-1BETA GENERATION== | ||
| - | <StructureSection load='1dgn' size='340' side='right'caption='[[1dgn | + | <StructureSection load='1dgn' size='340' side='right'caption='[[1dgn]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1dgn]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DGN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DGN FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[1dgn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DGN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DGN FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dgn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dgn OCA], [https://pdbe.org/1dgn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dgn RCSB], [https://www.ebi.ac.uk/pdbsum/1dgn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dgn ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dgn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dgn OCA], [https://pdbe.org/1dgn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dgn RCSB], [https://www.ebi.ac.uk/pdbsum/1dgn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dgn ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/CAR18_HUMAN CAR18_HUMAN] Inhibits generation of IL-1-beta by interacting with caspase-1 and preventing its association with RIP2. Down-regulates the release of IL1B.<ref>PMID:11051551</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Dixit | + | [[Category: Dixit VM]] |
| - | [[Category: Fairbrother | + | [[Category: Fairbrother WJ]] |
| - | [[Category: Humke | + | [[Category: Humke EW]] |
| - | [[Category: Shriver | + | [[Category: Shriver SK]] |
| - | [[Category: Starovasnik | + | [[Category: Starovasnik MA]] |
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Current revision
SOLUTION STRUCTURE OF ICEBERG, AN INHIBITOR OF INTERLEUKIN-1BETA GENERATION
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