Aminoacyl tRNA synthetase 3D structures

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Line 23: Line 23:
* ''Arg-RS + tRNA''
* ''Arg-RS + tRNA''
-
**[[2zuf]] - PhArgRS + tRNA-Arg - ''Pyrococcus horikoshii''<br />
+
 
**[[1f7v]] - yArgRS + Arg-tRNA<br />
**[[1f7v]] - yArgRS + Arg-tRNA<br />
 +
**[[2zuf]] - PhArgRS + tRNA-Arg - ''Pyrococcus horikoshii''<br />
**[[5yyn]], [[5b63]] - EcArgRS + Arg-tRNA<br />
**[[5yyn]], [[5b63]] - EcArgRS + Arg-tRNA<br />
Line 60: Line 61:
* ''Gln-RS ternary complex''
* ''Gln-RS ternary complex''
 +
**[[1euq]], [[1euy]] – EcGlnRS + Gln-tRNA + Gln-SA<br />
**[[1euq]], [[1euy]] – EcGlnRS + Gln-tRNA + Gln-SA<br />
**[[1exd]] - EcGlnRS + Gln-tRNA (mutant) + AMP<br />
**[[1exd]] - EcGlnRS + Gln-tRNA (mutant) + AMP<br />
Line 82: Line 84:
* ''Glu-RS + small substrates or analogs''
* ''Glu-RS + small substrates or analogs''
 +
**[[3afh]] - TmGluRS + Glu-AMP analog<br />
**[[3afh]] - TmGluRS + Glu-AMP analog<br />
**[[2rd2]], [[2re8]] – EcGluRS (mutant) + Glu-SA<br />
**[[2rd2]], [[2re8]] – EcGluRS (mutant) + Glu-SA<br />
Line 93: Line 96:
* ''Glu-RS + tRNA''
* ''Glu-RS + tRNA''
 +
**[[1zjw]] – EcGluRS + Glu-tRNA<br />
**[[1zjw]] – EcGluRS + Glu-tRNA<br />
**[[1g59]] – TtGluRS + Glu-tRNA<br />
**[[1g59]] – TtGluRS + Glu-tRNA<br />
* ''Glu-RS ternary complex''
* ''Glu-RS ternary complex''
 +
**[[5bmu]] – hGluRS GST-like domain + EPRS-AIMP3 <br />
**[[5bmu]] – hGluRS GST-like domain + EPRS-AIMP3 <br />
**[[2hrk]], [[2hsm]] - yGluRS N-terminal + GU4 nucleic-binding protein 1<br />
**[[2hrk]], [[2hsm]] - yGluRS N-terminal + GU4 nucleic-binding protein 1<br />
Line 112: Line 117:
* ''Ile-RS + small substrates or analogs''
* ''Ile-RS + small substrates or analogs''
 +
**[[1ue0]] - TtIleRS editing domain + Val<br />
**[[1ue0]] - TtIleRS editing domain + Val<br />
**[[1wnz]] - TtIleS editing domain + Val-adenylate<br />
**[[1wnz]] - TtIleS editing domain + Val-adenylate<br />
Line 119: Line 125:
* ''Ile-RS ternary complex''
* ''Ile-RS ternary complex''
 +
**[[1ffy]], [[1qu2]], [[1qu3]] - SaIleRS + Ile-tRNA + antibiotic - ''Staphylococcus aureus''<br />
**[[1ffy]], [[1qu2]], [[1qu3]] - SaIleRS + Ile-tRNA + antibiotic - ''Staphylococcus aureus''<br />
**[[6ldk]] - CaIleRS + AMP + Ile – ''Candida albicans''<br />
**[[6ldk]] - CaIleRS + AMP + Ile – ''Candida albicans''<br />
-
*'''Leu-RS'''
+
*'''Leu-RS'''; Domains – editing 260-530;
**[[2wfd]] – hLeuRS editing domain 260-509<br />
**[[2wfd]] – hLeuRS editing domain 260-509<br />
-
**[[3o0a]], [[3pz0]] – AaLeuRS hydrolytic domain – ''Aquifex aeolicus''<br />
+
**[[3o0a]], [[3pz0]] – AaLeuRS editing domain – ''Aquifex aeolicus''<br />
-
**[[3pz5]] – AaLeuRS hydrolytic domain (mutant)<br />
+
**[[3pz5]] – AaLeuRS editing domain (mutant)<br />
**[[2wfe]] - CaLeuRS editing domain – ''Candida albicans''<br />
**[[2wfe]] - CaLeuRS editing domain – ''Candida albicans''<br />
**[[5agh]] - CaLeuRS editing domain (mutant)<br />
**[[5agh]] - CaLeuRS editing domain (mutant)<br />
-
**[[2ajg]] - EcLeuRS editing domain<br />
+
**[[2ajg]] - EcLeuRS editing domain 228-413<br />
**[[1wkb]] – PhLeuRS residues 1-810<br />
**[[1wkb]] – PhLeuRS residues 1-810<br />
**[[5fon]] - CmLeuRS editing domain – ''Cryptosporidium muris''<br />
**[[5fon]] - CmLeuRS editing domain – ''Cryptosporidium muris''<br />
Line 137: Line 144:
**[[4k48]] - SpLeuRS editing domain (mutant) – ''Streptococcus pneumoniae''<br />
**[[4k48]] - SpLeuRS editing domain (mutant) – ''Streptococcus pneumoniae''<br />
**[[3pz6]] - LeuRS editing domain (mutant) – ''Giardia intestinalis''<br />
**[[3pz6]] - LeuRS editing domain (mutant) – ''Giardia intestinalis''<br />
 +
**[[7nu4]] - NgLeuRS<br />
 +
**[[7nty]], [[7nu1]], [[7nua]] - NgLeuRS (mutant)<br />
 +
**[[7n11]] - MaLeuRS editing domain – ''Mycobacteroides abscessus''<br />
* ''Leu-RS + small substrates or analogs''
* ''Leu-RS + small substrates or analogs''
 +
**[[6kqy]] - hLeuRS + Leu<br />
**[[6kqy]] - hLeuRS + Leu<br />
**[[7d5c]] - yLeuRS + inhibitor<br />
**[[7d5c]] - yLeuRS + inhibitor<br />
 +
**[[7nu5]] - NgLeuRS + Leu<br />
**[[6ykk]], [[6ykl]], [[6ykn]], [[6yko]], [[6ykq]], [[6yks]], [[6ykt]], [[6yku]], [[6ykv]], [[6kyw]], [[6ykx]], [[7a0p]], [[7ap2]] - NgLeuRS (mutant) + inhibitor<br />
**[[6ykk]], [[6ykl]], [[6ykn]], [[6yko]], [[6ykq]], [[6yks]], [[6ykt]], [[6yku]], [[6ykv]], [[6kyw]], [[6ykx]], [[7a0p]], [[7ap2]] - NgLeuRS (mutant) + inhibitor<br />
-
**[[6q89]], [[6q8a]], [[6q8b]], [[6q8c]] - NgLeuRS (mutant) + intermediate analog<br />
+
**[[6q89]], [[6q8a]], [[6q8b]], [[6q8c]], [[7ntz]], [[7nu2]], [[7nub]] - NgLeuRS (mutant) + intermediate analog<br />
 +
**[[7nu6]], [[7nu7]] - NgLeuRS + ATP <br />
 +
**[[7nu9]] - NgLeuRS + ATP + leucinol<br />
 +
**[[7nu3]], [[7nuc]] - NgLeuRS (mutant) + ATP + leucinol<br />
 +
**[[7nu8]] - NgLeuRS + Leu-AMP <br />
**[[2wfg]] - CaLeuRS editing domain + benzoxaborole-AMP<br />
**[[2wfg]] - CaLeuRS editing domain + benzoxaborole-AMP<br />
**[[1h3n]] - TtLeuRS + Leu-SA<br />
**[[1h3n]] - TtLeuRS + Leu-SA<br />
Line 158: Line 174:
**[[4k47]] - SpLeuRS editing domain (mutant) + benzoxaborole-AMP <br />
**[[4k47]] - SpLeuRS editing domain (mutant) + benzoxaborole-AMP <br />
**[[3ziu]] - LeuRS editing domain + Leu-SA – ''Mycoplasma mobile''<br />
**[[3ziu]] - LeuRS editing domain + Leu-SA – ''Mycoplasma mobile''<br />
 +
**[[7n12]] - MaLeuRS editing domain + epetraborole-AMP<br />
* ''Leu-RS + tRNA''
* ''Leu-RS + tRNA''
 +
**[[1wz2]] – PhLeuRS + Leu-tRNA<br />
**[[1wz2]] – PhLeuRS + Leu-tRNA<br />
**[[5ah5]] - LeuRS + Leu-tRNA – ''Agrobacterium radiobacter''<br >
**[[5ah5]] - LeuRS + Leu-tRNA – ''Agrobacterium radiobacter''<br >
* ''Leu-RS ternary complex''
* ''Leu-RS ternary complex''
 +
**[[6kie]], [[6kr7]] - hLeuRS + Leu-SA + Leu<br />
**[[6kie]], [[6kr7]] - hLeuRS + Leu-SA + Leu<br />
**[[6lpf]], [[6lr6]] - hLeuRS + Leu-SA + adenosine derivative<br />
**[[6lpf]], [[6lr6]] - hLeuRS + Leu-SA + adenosine derivative<br />
Line 181: Line 200:
**[[3bju]] – hLysRS residues 70-579<br />
**[[3bju]] – hLysRS residues 70-579<br />
-
**[[6ilh]] - hLysRS (mutant)<br />
+
**[[6ilh]], [[7ea9]] - hLysRS (mutant)<br />
 +
**[[7f6w]] – yLysRS<br />
**[[1irx]] – PhLysRS<br />
**[[1irx]] – PhLysRS<br />
**[[1bbw]] – EcLysRS<br />
**[[1bbw]] – EcLysRS<br />
Line 240: Line 260:
**[[1mkh]] – PabMetRS C-terminal<br />
**[[1mkh]] – PabMetRS C-terminal<br />
**[[5xgq]] – MtMetRS<br />
**[[5xgq]] – MtMetRS<br />
-
**[[5h34]] – MetRS C-terminal – ''Nanoarchaeum equitans''<br />
+
**[[5h34]] – NeMetRS C-terminal – ''Nanoarchaeum equitans''<br />
**[[2x1l]] - MsMetRS residues 2-515 <br />
**[[2x1l]] - MsMetRS residues 2-515 <br />
 +
**[[7wpj]] – SaMetRS<br />
* ''Met-RS + small substrates or analogs''
* ''Met-RS + small substrates or analogs''
 +
**[[5goy]] – hMetRS residues 221-834 + Met<br />
**[[5goy]] – hMetRS residues 221-834 + Met<br />
**[[3kfl]] – LmMetRS residues 206-747+ Met-adenylate - ''Leishmania major''<br />
**[[3kfl]] – LmMetRS residues 206-747+ Met-adenylate - ''Leishmania major''<br />
Line 266: Line 288:
**[[6cml]], [[6mes]] - TbMetRS residues 237-773 (mutant) + Met + inhibitor <br />
**[[6cml]], [[6mes]] - TbMetRS residues 237-773 (mutant) + Met + inhibitor <br />
**[[4qrd]], [[4qre]] - SaMetRS + antibacterial<br />
**[[4qrd]], [[4qre]] - SaMetRS + antibacterial<br />
 +
**[[7wpi]], [[7wpn]] - SaMetRS + inhibitor<br />
 +
**[[7wpk]] - SaMetRS + Met<br />
 +
**[[7wpl]] - SaMetRS + ATP<br />
 +
**[[7wpm]], [[7wpt]], [[7wpx]], [[7wq0]] - SaMetRS + inhibitor + ATP<br />
 +
**[[7ulz]] - PaMetRS + Met<br />
* ''Met-RS + tRNA''
* ''Met-RS + tRNA''
Line 298: Line 325:
**[[5tev]] - NgTrpRS <br />
**[[5tev]] - NgTrpRS <br />
**[[4j76]] - PfTrpRS <br />
**[[4j76]] - PfTrpRS <br />
 +
**[[7el8]] - MtTrpRS <br />
* ''Trp-RS + small substrates or analogs''
* ''Trp-RS + small substrates or analogs''
 +
**[[5ujj]] – hTrpRS + Trp-AMP<br />
**[[5ujj]] – hTrpRS + Trp-AMP<br />
**[[2quh]] – hTrpRS + Trp<br />
**[[2quh]] – hTrpRS + Trp<br />
Line 311: Line 340:
**[[2ov4]] – BsTrpRS + adenosine tetraphosphate<br />
**[[2ov4]] – BsTrpRS + adenosine tetraphosphate<br />
**[[1i6k]], [[1i6l]], [[1i6m]] – BsTrpRS + Trp-adenylate<br />
**[[1i6k]], [[1i6l]], [[1i6m]] – BsTrpRS + Trp-adenylate<br />
 +
**[[1maw]], [[1m83]] - BsTrpRS + ATP<br />
 +
**[[1mb2]] - BsTrpRS + Trp<br />
 +
**[[7cms]] - BsTrpRS + antibiotic<br />
**[[1yid]], [[2a4m]] – DrTrpRS + ATP<br />
**[[1yid]], [[2a4m]] – DrTrpRS + ATP<br />
**[[1yi8]], [[1yia]]– DrTrpRS + Trp<br />
**[[1yi8]], [[1yia]]– DrTrpRS + Trp<br />
-
**[[1maw]], [[1m83]] - BsTrpRS + ATP<br />
 
-
**[[1mb2]] - BsTrpRS + Trp<br />
 
**[[1bks]] – StTrpRS + pyridoxal phosphate<br />
**[[1bks]] – StTrpRS + pyridoxal phosphate<br />
**[[6ncr]] - CtTrpRS + Trp<br />
**[[6ncr]] - CtTrpRS + Trp<br />
**[[5tew]] - NgTrpRS + Trp<br />
**[[5tew]] - NgTrpRS + Trp<br />
**[[4j75]] - PfTrpRS + Trp-AMP<br />
**[[4j75]] - PfTrpRS + Trp-AMP<br />
 +
**[[7elt]] - MtTrpRS + Trp-AMP<br />
**[[6dfu]] - TrpRS + Trp – ''Haemophilus influenzae''<br />
**[[6dfu]] - TrpRS + Trp – ''Haemophilus influenzae''<br />
*''Trp-RS ternary complex''
*''Trp-RS ternary complex''
-
**[[5ekd]] – hTrpRS + ATP + indolmycin<br />
+
**[[5ekd]] – hTrpRS + ATP + antibiotic<br />
-
**[[5dk4]] – BsTrpRS + ATP + indolmycin<br />
+
**[[5dk4]], [[7cki]] – BsTrpRS + ATP + antibiotic<br />
 +
**[[7eer]] – BsTrpRS + ATP + inhibitor<br />
**[[3fhj]], [[3ghd]], [[3fi0]] – BsTrpRS + Trp + AMP + Pi<br />
**[[3fhj]], [[3ghd]], [[3fi0]] – BsTrpRS + Trp + AMP + Pi<br />
**[[1mau]] – BsTrpRS + Trp + ATP<br />
**[[1mau]] – BsTrpRS + Trp + ATP<br />
**[[5v0i]] - EcTrpRS + Trp + AMP<br />
**[[5v0i]] - EcTrpRS + Trp + AMP<br />
 +
**[[7ens]] – MtTrpRS + ATP + antibiotic<br />
 +
**[[7ent]], [[7ev2]], [[7ev3]] – MtTrpRS + ATP + inhibitor<br />
* ''Trp-RS + tRNA''
* ''Trp-RS + tRNA''
 +
**[[2ake]], [[2dr2]] - hTrpRS + Trp-tRNA<br />
**[[2ake]], [[2dr2]] - hTrpRS + Trp-tRNA<br />
**[[2azx]] – hTrpRS (mutant) + tRNA<br />
**[[2azx]] – hTrpRS (mutant) + tRNA<br />
Line 341: Line 376:
**[[1tya]], [[1tyb]], [[1tyc]], [[1tyd]], [[2ts1]] – BsTyrRS<br />
**[[1tya]], [[1tyb]], [[1tyc]], [[1tyd]], [[2ts1]] – BsTyrRS<br />
**[[1jh3]] – BsTyrRS C-terminal – NMR<br />
**[[1jh3]] – BsTyrRS C-terminal – NMR<br />
-
**[[3qe4]], [[3d6u]], [[3d6v]], [[2pxh]], [[2hgz]], [[1u7d]], [[5n5v]], [[5nsf]] – MjTyrRS – ''Methanocaldococcus jannaschii''<br />
+
**[[3qe4]], [[3d6u]], [[3d6v]], [[2pxh]], [[2hgz]], [[1u7d]], [[5n5v]], [[5nsf]], [[7c5c]], [[7ckh]] – MjTyrRS – ''Methanocaldococcus jannaschii''<br />
**[[1u7x]], [[4hjr]], [[4hk4]], [[5u36]], [[5l7p]] - MjTyrRS (mutant) <br />
**[[1u7x]], [[4hjr]], [[4hk4]], [[5u36]], [[5l7p]] - MjTyrRS (mutant) <br />
**[[2jan]] – MtTyrRS<br />
**[[2jan]] – MtTyrRS<br />
Line 352: Line 387:
**[[2ktl]] - AnTyrRS C-terminal - NMR<br />
**[[2ktl]] - AnTyrRS C-terminal - NMR<br />
**[[5ijx]] - TyrRS – ''Coccidiodides posadasii''<br />
**[[5ijx]] - TyrRS – ''Coccidiodides posadasii''<br />
 +
**[[7fg6]] - NeTyrRS <br />
* ''Tyr-RS + small substrates or analogs''
* ''Tyr-RS + small substrates or analogs''
 +
**[[1q11]] – hTyrRS residues 1-364 + Tyr-ol<br />
**[[1q11]] – hTyrRS residues 1-364 + Tyr-ol<br />
**[[2pid]] – hTyrRS residues 28-375 + Tyr-SA<br />
**[[2pid]] – hTyrRS residues 28-375 + Tyr-SA<br />
Line 359: Line 396:
**[[4qbt]] - hTyrRS + Tyr<br />
**[[4qbt]] - hTyrRS + Tyr<br />
**[[3zxi]] - hTyrRS + Tyr-adenylate analog<br />
**[[3zxi]] - hTyrRS + Tyr-adenylate analog<br />
 +
**[[7rou]] – hTyrRS + Tyr derivative<br />
**[[3ts1]] – BsTyrRS + Tyr-adenylate intermediate<br />
**[[3ts1]] – BsTyrRS + Tyr-adenylate intermediate<br />
**[[4ts1]] – BsTyrRS + Tyr<br />
**[[4ts1]] – BsTyrRS + Tyr<br />
-
**[[3p0h]], 3p0i]], 3p0j]] – LmTyrRS + inhibitor <br />
+
**[[3p0h]], [[3p0i]], [[3p0j]] – LmTyrRS + inhibitor <br />
**[[3n2y]] – MjTyrRS + tetrazolyl phenylalanine<br />
**[[3n2y]] – MjTyrRS + tetrazolyl phenylalanine<br />
**[[2zp1]] – MjTyrRS (mutant) + Tyr<br />
**[[2zp1]] – MjTyrRS (mutant) + Tyr<br />
**[[1zh0]] - MjTyrRS (mutant) + naphthyl-Ala<br />
**[[1zh0]] - MjTyrRS (mutant) + naphthyl-Ala<br />
-
**[[1zh6]], [[2ag6]], [[4pbr]] - MjTyrRS (mutant) + Phe derivative<br />
+
**[[1zh6]], [[2ag6]], [[4pbr]], [[7ckg]] - MjTyrRS (mutant) + Phe derivative<br />
**[[4hjx]] - MjTyrRS (mutant) + di-fluoro-Tyr<br />
**[[4hjx]] - MjTyrRS (mutant) + di-fluoro-Tyr<br />
**[[4nx2]] - MjTyrRS (mutant) + di-chloro-Tyr<br />
**[[4nx2]] - MjTyrRS (mutant) + di-chloro-Tyr<br />
Line 387: Line 425:
**[[1jii]], [[1jij]], [[1jil]], [[1jik]] – SaTyrRS + inhibitor <br />
**[[1jii]], [[1jij]], [[1jil]], [[1jik]] – SaTyrRS + inhibitor <br />
**[[6otj]] – NgTyrRS + Tyr<br />
**[[6otj]] – NgTyrRS + Tyr<br />
 +
**[[7ror]] – PfTyrRS + Tyr-AMP<br />
 +
**[[7ros]] – PfTyrRS + Tyr derivative<br />
 +
**[[7rot]] – PfTyrRS (mutant) + Tyr derivative<br />
* ''Tyr-RS + tRNA''
* ''Tyr-RS + tRNA''
Line 394: Line 435:
**[[1h3e]] - TtTyrRS + Tyr-tRNA + Tyr-ol + ATP<br />
**[[1h3e]] - TtTyrRS + Tyr-tRNA + Tyr-ol + ATP<br />
**[[2rkj]] – NcTyrRS + RNA<br />
**[[2rkj]] – NcTyrRS + RNA<br />
 +
**[[7sc6]], [[7scq]] – TyrRS + RNA – ''Phaseolus vulgaris''<br />
*'''3-nitroTyr-RS'''
*'''3-nitroTyr-RS'''
Line 453: Line 495:
* ''Asp-RS + small substrates or analogs''
* ''Asp-RS + small substrates or analogs''
 +
**[[3nel]] – TkAspRS + Asp<br />
**[[3nel]] – TkAspRS + Asp<br />
**[[3nem]] - TkAspRS + Asp-adenylate<br />
**[[3nem]] - TkAspRS + Asp-adenylate<br />
Line 484: Line 527:
* ''Asn-RS + small substrates or analogs''
* ''Asn-RS + small substrates or analogs''
 +
**[[2xti]] – BmAsnRS catalytic fragment + Asn-adenine analog<br />
**[[2xti]] – BmAsnRS catalytic fragment + Asn-adenine analog<br />
**[[2xgt]] - BmAsnRS catalytic fragment + Asn-SA<br />
**[[2xgt]] - BmAsnRS catalytic fragment + Asn-SA<br />
Line 503: Line 547:
* ''Gly-RS + small substrates or analogs''
* ''Gly-RS + small substrates or analogs''
 +
**[[2zt5]], [[2zxf]] – hGlyRS residues 55-739 + bis-adenosine tetraphosphate<br />
**[[2zt5]], [[2zxf]] – hGlyRS residues 55-739 + bis-adenosine tetraphosphate<br />
**[[2zt6]] - hGlyRS residues 55-739 + AMPCPP<br />
**[[2zt6]] - hGlyRS residues 55-739 + AMPCPP<br />
Line 511: Line 556:
**[[5f5w]] - AaGlyRS + Gly-adenylate<br />
**[[5f5w]] - AaGlyRS + Gly-adenylate<br />
**[[3ufg]] - CjGlyRS + ATP<br />
**[[3ufg]] - CjGlyRS + ATP<br />
 +
**[[7eiv]] - EcGlyRS + ANP + Gly<br />
* ''Gly-RS + tRNA''
* ''Gly-RS + tRNA''
Line 521: Line 567:
**[[4x5o]], [[4g84]], [[4g85]], [[6o76]] - hHisRS <br />
**[[4x5o]], [[4g84]], [[4g85]], [[6o76]] - hHisRS <br />
**[[5w6m]] - hHisRS (mutant)<br />
**[[5w6m]] - hHisRS (mutant)<br />
-
**[[1x59, [[2lw7]] – hHisRS WHEP-TRS domain - NMR<br />
+
**[[1x59]], [[2lw7]] – hHisRS WHEP-TRS domain - NMR<br />
**[[1htt]] - EcHisRS<br />
**[[1htt]] - EcHisRS<br />
**[[3net]] – HisRS – ''Nostoc''<br />
**[[3net]] – HisRS – ''Nostoc''<br />
Line 530: Line 576:
* ''His-RS + small substrates or analogs''
* ''His-RS + small substrates or analogs''
 +
**[[4phc]] - hHisRS + His <br />
**[[4phc]] - hHisRS + His <br />
**[[3lc0]] – TcHisRS residues 45-478 + His – ''Trypanosoma cruzi''<br />
**[[3lc0]] – TcHisRS residues 45-478 + His – ''Trypanosoma cruzi''<br />
Line 542: Line 589:
**[[3hrk]] - TbHisRS + His-adenylate<br />
**[[3hrk]] - TbHisRS + His-adenylate<br />
**[[2el9]] - EcHisRS + His-SA<br />
**[[2el9]] - EcHisRS + His-SA<br />
-
**[[1kmm]], 1ady]] - EcHisRS + His-adenylate<br />
+
**[[1kmm]], [[1ady]] - EcHisRS + His-adenylate<br />
**[[1kmn]] - EcHisRS + His-ol + ATP<br />
**[[1kmn]] - EcHisRS + His-ol + ATP<br />
**[[5e3i]] - AbHisRS + His + ATP<br />
**[[5e3i]] - AbHisRS + His + ATP<br />
Line 558: Line 605:
**[[7daw]] – MtPheRS + α+β chains <br />
**[[7daw]] – MtPheRS + α+β chains <br />
**[[6p24]] – EcPheRS + α+β chains <br />
**[[6p24]] – EcPheRS + α+β chains <br />
 +
**[[7n8y]] - SePheRS + chains – ''Salmonella enterica''<br />
* ''Phe-RS + small substrates or analogs''
* ''Phe-RS + small substrates or analogs''
 +
**[[3hfv]] – hPheRS + Tyr<br />
**[[3hfv]] – hPheRS + Tyr<br />
**[[3teg]] – hPheRS + L-DOPA<br />
**[[3teg]] – hPheRS + L-DOPA<br />
Line 574: Line 623:
**[[7db7]], [[7db8]] – MtPheRS α+β chains + inhibitor<br />
**[[7db7]], [[7db8]] – MtPheRS α+β chains + inhibitor<br />
**[[6p8t]] – AbPheRS α+β chains + inhibitor<br />
**[[6p8t]] – AbPheRS α+β chains + inhibitor<br />
 +
**[[7dpi]] – PfPheRS + α+β chains + inhibitor<br />
* ''Phe-RS + tRNA''
* ''Phe-RS + tRNA''
 +
**[[3tup]] – hPheRS + Phe-tRNA<br />
**[[3tup]] – hPheRS + Phe-tRNA<br />
**[[1eiy]] - TtPheRS α+β chains + Phe-tRNA<br />
**[[1eiy]] - TtPheRS α+β chains + Phe-tRNA<br />
**[[2iy5]] - TtPheRS α+β chains + Phe-ol + Phe-tRNA<br />
**[[2iy5]] - TtPheRS α+β chains + Phe-ol + Phe-tRNA<br />
 +
**[[7k98]], [[7k9m]], [[7ka0]] - MtPheRS + chains + Phe-tRNA + Phe-AMS<br />
 +
**[[7kab]] - MtPheRS + chains + Phe-tRNA + Phe<br />
*'''Pro-RS'''
*'''Pro-RS'''
Line 592: Line 645:
* ''Pro-RS + small substrates or analogs''
* ''Pro-RS + small substrates or analogs''
 +
**[[3ial]] – GlProRS residues 34-542 + Pro-adenylate<br />
**[[3ial]] – GlProRS residues 34-542 + Pro-adenylate<br />
**[[2i4m]], [[2i4n]] – RpProRS + aa-SA<br />
**[[2i4m]], [[2i4n]] – RpProRS + aa-SA<br />
Line 599: Line 653:
**[[1h4t]] - TtProRS + Pro<br />
**[[1h4t]] - TtProRS + Pro<br />
**[[5ifu]] – PfProRS residues 249-746 + glyburide <br />
**[[5ifu]] – PfProRS residues 249-746 + glyburide <br />
-
**[[4wi1]] – PfProRS residues 249-746 + inhibitor<br />
+
**[[4wi1]], [[6t7k]], [[7qc1]] – PfProRS residues 249-746 + inhibitor<br />
*''Pro-RS ternary complex''
*''Pro-RS ternary complex''
 +
**[[4k87]] – hProRS residues 1000-1512 + proline + adenosine<br />
**[[4k87]] – hProRS residues 1000-1512 + proline + adenosine<br />
**[[4k88]] – hProRS residues 1000-1512 + halofunginone<br />
**[[4k88]] – hProRS residues 1000-1512 + halofunginone<br />
Line 615: Line 670:
**[[6uyh]] – NfProRS + halofuginone + ANP <br />
**[[6uyh]] – NfProRS + halofuginone + ANP <br />
**[[5xiq]] – TgProRS residues 334-830 + halofuginone + ANP <br />
**[[5xiq]] – TgProRS residues 334-830 + halofuginone + ANP <br />
 +
**[[7evu]], [[7f9u]], [[7f9v]] – TgProRS residues 215-711 + halofuginone + inhibitor <br />
 +
**[[7f9r]] – TgProRS residues 215-711 + febrifugine + inhibitor + Pro<br />
 +
**[[7evv]], [[7fal]] – TgProRS residues 215-711 + inhibitor + Pro <br />
**[[5xik]], [[6a88]] – TgProRS residues 334-830 + febrifugine derivative + ANP <br />
**[[5xik]], [[6a88]] – TgProRS residues 334-830 + febrifugine derivative + ANP <br />
**[[5xig]], [[5xih]], [[5xij]] – TgProRS residues 334-830 + inhibitor + ANP <br />
**[[5xig]], [[5xih]], [[5xij]] – TgProRS residues 334-830 + inhibitor + ANP <br />
**[[5xii]] – TgProRS residues 334-830 (mutant) + inhibitor + ANP <br />
**[[5xii]] – TgProRS residues 334-830 (mutant) + inhibitor + ANP <br />
**[[4ydq]], [[4q15]], [[4olf]] – PfProRS residues 254-746 + halofuginone + AMPPNP <br />
**[[4ydq]], [[4q15]], [[4olf]] – PfProRS residues 254-746 + halofuginone + AMPPNP <br />
-
**[[6t7k]] – PfProRS residues 254-746 + inhibitor <br />
+
**[[7qb7]], [[7qc2]] – PfProRS residues 249-746 + inhibitor + Pro <br />
*'''Bifunctional RS''' (bifunctional glutamate/proline tRNA ligase)
*'''Bifunctional RS''' (bifunctional glutamate/proline tRNA ligase)
Line 626: Line 684:
**[[5v58]] – hGlu/ProRS residues 1003-1513 + AZ-SA<br />
**[[5v58]] – hGlu/ProRS residues 1003-1513 + AZ-SA<br />
**[[5vad]] – hGlu/ProRS residues 1003-1513 + inhibitor<br />
**[[5vad]] – hGlu/ProRS residues 1003-1513 + inhibitor<br />
-
**[[5a1n]], [[5a34]], [[5a5h]] – hGlu/ProRS GST-like domain + EPRS-AIMP2<br />
+
**[[7osy]] – hGlu/ProRS residues 1003-1513 + Pro<br />
-
**[[1fyj]] – hGlu/ProRS 677-733 – NMR<br />, [[6
+
**[[7bbu]], [[7f98]], [[7f99]], [[7f9a]], [[7f9b]], [[7f9c]], [[7f9d]], [[7osz]], [[7ot0]], [[7ot1]], [[7ot2]], [[7ot3]] – hGlu/ProRS residues 1003-1513 + inhibitor + Pro<br />
 +
**[[7x09]], [[7x1o]] – hGlu/ProRS residues 1003-1513 + inhibitor + halofuginone<br />
 +
**[[7y1w]], [[7y28]], [[7y3s]] – hGlu/ProRS residues 1003-1513 + inhibitor + ATP<br />
 +
**[[5a1n]], [[5a34]], [[5a5h]] – hGlu/ProRS GST-like domain 1-175 + EPRS-AIMP2<br />
 +
**[[1fyj]] – hGlu/ProRS 677-733 – NMR<br />
*'''Pyrrolysyl-RS'''; domains – RNA-binding 1-101; catalytic 188-454
*'''Pyrrolysyl-RS'''; domains – RNA-binding 1-101; catalytic 188-454
Line 635: Line 697:
**[[3dsq]] – DhPylRS<br />
**[[3dsq]] – DhPylRS<br />
**[[6ezd]], [[6jp2]] – PylRS – ''Methanomethylophilus alvus''<br />
**[[6ezd]], [[6jp2]] – PylRS – ''Methanomethylophilus alvus''<br />
 +
**[[7r6o]] - PylRS 1-273 – ''Methanogenic archaeon"<br />
*''Pyrrolysyl-RS binary complex''
*''Pyrrolysyl-RS binary complex''
Line 661: Line 724:
**[[6ly3]], [[6ly6]], [[6lyb]] - MmPylRS catalytic domain (mutant) + Ala derivative+ ANP <br />
**[[6ly3]], [[6ly6]], [[6lyb]] - MmPylRS catalytic domain (mutant) + Ala derivative+ ANP <br />
**[[6ly7]], [[6lya]] - MmPylRS catalytic domain (mutant) + Trp derivative + ANP <br />
**[[6ly7]], [[6lya]] - MmPylRS catalytic domain (mutant) + Trp derivative + ANP <br />
 +
**[[7rsm]] - MmPylRS catalytic domain (mutant) + Phe derivative + ANP <br />
**[[2zin]] - MmPylRS catalytic domain + butoxycarbonyl lysine + ATP analog <br />
**[[2zin]] - MmPylRS catalytic domain + butoxycarbonyl lysine + ATP analog <br />
**[[6aac]], [[6aad]], [[6aao]], [[6aap]], [[6aaz]], [[6ab0]], [[6ab1]], [[6ab2]], [[6ab8]], [[6abk]], [[6abl]], [[6abm]], [[6aan]], [[6anq]] - MmPylRS catalytic domain + azanyl derivative + ATP <br />
**[[6aac]], [[6aad]], [[6aao]], [[6aap]], [[6aaz]], [[6ab0]], [[6ab1]], [[6ab2]], [[6ab8]], [[6abk]], [[6abl]], [[6abm]], [[6aan]], [[6anq]] - MmPylRS catalytic domain + azanyl derivative + ATP <br />
Line 716: Line 780:
**[[1y2q]] - PabThrRS editing domain 1-143<br />
**[[1y2q]] - PabThrRS editing domain 1-143<br />
**[[1tje]] - EcThrRS editing domain 1-224<br />
**[[1tje]] - EcThrRS editing domain 1-224<br />
-
**[[7l3o]] - CpThrRS <br />
+
**[[7l3o]] RBD 330-763 - CpThrRS <br />
* ''Thr-RS + small substrates or analogs''
* ''Thr-RS + small substrates or analogs''
Line 741: Line 805:
**[[4rrf]] - MjThrRS editing domain + Ser<br />
**[[4rrf]] - MjThrRS editing domain + Ser<br />
**[[4rrg]] - MjThrRS editing domain + Thr<br />
**[[4rrg]] - MjThrRS editing domain + Thr<br />
-
**[[6l2q]] - ThrRS 222-622 + inhibitor – ''Salmonella enterica''<br />
+
**[[6l2q]], [[7cbg]], [[7cbi]], [[7cbh]], [[7wm7]], [[7wmf]], [[7wmi]] - SeThrRS 222-622 + inhibitor <br />
* ''Thr-RS + tRNA''
* ''Thr-RS + tRNA''

Current revision

3D Structures of Aminoacyl tRNA Synthetase

Updated on 24-September-2024

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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