Aminoacyl tRNA synthetase 3D structures
From Proteopedia
(Difference between revisions)
| (3 intermediate revisions not shown.) | |||
| Line 23: | Line 23: | ||
* ''Arg-RS + tRNA'' | * ''Arg-RS + tRNA'' | ||
| - | + | ||
**[[1f7v]] - yArgRS + Arg-tRNA<br /> | **[[1f7v]] - yArgRS + Arg-tRNA<br /> | ||
| + | **[[2zuf]] - PhArgRS + tRNA-Arg - ''Pyrococcus horikoshii''<br /> | ||
**[[5yyn]], [[5b63]] - EcArgRS + Arg-tRNA<br /> | **[[5yyn]], [[5b63]] - EcArgRS + Arg-tRNA<br /> | ||
| Line 60: | Line 61: | ||
* ''Gln-RS ternary complex'' | * ''Gln-RS ternary complex'' | ||
| + | |||
**[[1euq]], [[1euy]] – EcGlnRS + Gln-tRNA + Gln-SA<br /> | **[[1euq]], [[1euy]] – EcGlnRS + Gln-tRNA + Gln-SA<br /> | ||
**[[1exd]] - EcGlnRS + Gln-tRNA (mutant) + AMP<br /> | **[[1exd]] - EcGlnRS + Gln-tRNA (mutant) + AMP<br /> | ||
| Line 82: | Line 84: | ||
* ''Glu-RS + small substrates or analogs'' | * ''Glu-RS + small substrates or analogs'' | ||
| + | |||
**[[3afh]] - TmGluRS + Glu-AMP analog<br /> | **[[3afh]] - TmGluRS + Glu-AMP analog<br /> | ||
**[[2rd2]], [[2re8]] – EcGluRS (mutant) + Glu-SA<br /> | **[[2rd2]], [[2re8]] – EcGluRS (mutant) + Glu-SA<br /> | ||
| Line 93: | Line 96: | ||
* ''Glu-RS + tRNA'' | * ''Glu-RS + tRNA'' | ||
| + | |||
**[[1zjw]] – EcGluRS + Glu-tRNA<br /> | **[[1zjw]] – EcGluRS + Glu-tRNA<br /> | ||
**[[1g59]] – TtGluRS + Glu-tRNA<br /> | **[[1g59]] – TtGluRS + Glu-tRNA<br /> | ||
* ''Glu-RS ternary complex'' | * ''Glu-RS ternary complex'' | ||
| + | |||
**[[5bmu]] – hGluRS GST-like domain + EPRS-AIMP3 <br /> | **[[5bmu]] – hGluRS GST-like domain + EPRS-AIMP3 <br /> | ||
**[[2hrk]], [[2hsm]] - yGluRS N-terminal + GU4 nucleic-binding protein 1<br /> | **[[2hrk]], [[2hsm]] - yGluRS N-terminal + GU4 nucleic-binding protein 1<br /> | ||
| Line 112: | Line 117: | ||
* ''Ile-RS + small substrates or analogs'' | * ''Ile-RS + small substrates or analogs'' | ||
| + | |||
**[[1ue0]] - TtIleRS editing domain + Val<br /> | **[[1ue0]] - TtIleRS editing domain + Val<br /> | ||
**[[1wnz]] - TtIleS editing domain + Val-adenylate<br /> | **[[1wnz]] - TtIleS editing domain + Val-adenylate<br /> | ||
| Line 119: | Line 125: | ||
* ''Ile-RS ternary complex'' | * ''Ile-RS ternary complex'' | ||
| + | |||
**[[1ffy]], [[1qu2]], [[1qu3]] - SaIleRS + Ile-tRNA + antibiotic - ''Staphylococcus aureus''<br /> | **[[1ffy]], [[1qu2]], [[1qu3]] - SaIleRS + Ile-tRNA + antibiotic - ''Staphylococcus aureus''<br /> | ||
**[[6ldk]] - CaIleRS + AMP + Ile – ''Candida albicans''<br /> | **[[6ldk]] - CaIleRS + AMP + Ile – ''Candida albicans''<br /> | ||
| - | *'''Leu-RS''' | + | *'''Leu-RS'''; Domains – editing 260-530; |
**[[2wfd]] – hLeuRS editing domain 260-509<br /> | **[[2wfd]] – hLeuRS editing domain 260-509<br /> | ||
| - | **[[3o0a]], [[3pz0]] – AaLeuRS | + | **[[3o0a]], [[3pz0]] – AaLeuRS editing domain – ''Aquifex aeolicus''<br /> |
| - | **[[3pz5]] – AaLeuRS | + | **[[3pz5]] – AaLeuRS editing domain (mutant)<br /> |
**[[2wfe]] - CaLeuRS editing domain – ''Candida albicans''<br /> | **[[2wfe]] - CaLeuRS editing domain – ''Candida albicans''<br /> | ||
**[[5agh]] - CaLeuRS editing domain (mutant)<br /> | **[[5agh]] - CaLeuRS editing domain (mutant)<br /> | ||
| - | **[[2ajg]] - EcLeuRS editing domain<br /> | + | **[[2ajg]] - EcLeuRS editing domain 228-413<br /> |
**[[1wkb]] – PhLeuRS residues 1-810<br /> | **[[1wkb]] – PhLeuRS residues 1-810<br /> | ||
**[[5fon]] - CmLeuRS editing domain – ''Cryptosporidium muris''<br /> | **[[5fon]] - CmLeuRS editing domain – ''Cryptosporidium muris''<br /> | ||
| Line 137: | Line 144: | ||
**[[4k48]] - SpLeuRS editing domain (mutant) – ''Streptococcus pneumoniae''<br /> | **[[4k48]] - SpLeuRS editing domain (mutant) – ''Streptococcus pneumoniae''<br /> | ||
**[[3pz6]] - LeuRS editing domain (mutant) – ''Giardia intestinalis''<br /> | **[[3pz6]] - LeuRS editing domain (mutant) – ''Giardia intestinalis''<br /> | ||
| + | **[[7nu4]] - NgLeuRS<br /> | ||
| + | **[[7nty]], [[7nu1]], [[7nua]] - NgLeuRS (mutant)<br /> | ||
| + | **[[7n11]] - MaLeuRS editing domain – ''Mycobacteroides abscessus''<br /> | ||
* ''Leu-RS + small substrates or analogs'' | * ''Leu-RS + small substrates or analogs'' | ||
| + | |||
**[[6kqy]] - hLeuRS + Leu<br /> | **[[6kqy]] - hLeuRS + Leu<br /> | ||
**[[7d5c]] - yLeuRS + inhibitor<br /> | **[[7d5c]] - yLeuRS + inhibitor<br /> | ||
| + | **[[7nu5]] - NgLeuRS + Leu<br /> | ||
**[[6ykk]], [[6ykl]], [[6ykn]], [[6yko]], [[6ykq]], [[6yks]], [[6ykt]], [[6yku]], [[6ykv]], [[6kyw]], [[6ykx]], [[7a0p]], [[7ap2]] - NgLeuRS (mutant) + inhibitor<br /> | **[[6ykk]], [[6ykl]], [[6ykn]], [[6yko]], [[6ykq]], [[6yks]], [[6ykt]], [[6yku]], [[6ykv]], [[6kyw]], [[6ykx]], [[7a0p]], [[7ap2]] - NgLeuRS (mutant) + inhibitor<br /> | ||
| - | **[[6q89]], [[6q8a]], [[6q8b]], [[6q8c]] - NgLeuRS (mutant) + intermediate analog<br /> | + | **[[6q89]], [[6q8a]], [[6q8b]], [[6q8c]], [[7ntz]], [[7nu2]], [[7nub]] - NgLeuRS (mutant) + intermediate analog<br /> |
| + | **[[7nu6]], [[7nu7]] - NgLeuRS + ATP <br /> | ||
| + | **[[7nu9]] - NgLeuRS + ATP + leucinol<br /> | ||
| + | **[[7nu3]], [[7nuc]] - NgLeuRS (mutant) + ATP + leucinol<br /> | ||
| + | **[[7nu8]] - NgLeuRS + Leu-AMP <br /> | ||
**[[2wfg]] - CaLeuRS editing domain + benzoxaborole-AMP<br /> | **[[2wfg]] - CaLeuRS editing domain + benzoxaborole-AMP<br /> | ||
**[[1h3n]] - TtLeuRS + Leu-SA<br /> | **[[1h3n]] - TtLeuRS + Leu-SA<br /> | ||
| Line 158: | Line 174: | ||
**[[4k47]] - SpLeuRS editing domain (mutant) + benzoxaborole-AMP <br /> | **[[4k47]] - SpLeuRS editing domain (mutant) + benzoxaborole-AMP <br /> | ||
**[[3ziu]] - LeuRS editing domain + Leu-SA – ''Mycoplasma mobile''<br /> | **[[3ziu]] - LeuRS editing domain + Leu-SA – ''Mycoplasma mobile''<br /> | ||
| + | **[[7n12]] - MaLeuRS editing domain + epetraborole-AMP<br /> | ||
* ''Leu-RS + tRNA'' | * ''Leu-RS + tRNA'' | ||
| + | |||
**[[1wz2]] – PhLeuRS + Leu-tRNA<br /> | **[[1wz2]] – PhLeuRS + Leu-tRNA<br /> | ||
**[[5ah5]] - LeuRS + Leu-tRNA – ''Agrobacterium radiobacter''<br > | **[[5ah5]] - LeuRS + Leu-tRNA – ''Agrobacterium radiobacter''<br > | ||
* ''Leu-RS ternary complex'' | * ''Leu-RS ternary complex'' | ||
| + | |||
**[[6kie]], [[6kr7]] - hLeuRS + Leu-SA + Leu<br /> | **[[6kie]], [[6kr7]] - hLeuRS + Leu-SA + Leu<br /> | ||
**[[6lpf]], [[6lr6]] - hLeuRS + Leu-SA + adenosine derivative<br /> | **[[6lpf]], [[6lr6]] - hLeuRS + Leu-SA + adenosine derivative<br /> | ||
| Line 181: | Line 200: | ||
**[[3bju]] – hLysRS residues 70-579<br /> | **[[3bju]] – hLysRS residues 70-579<br /> | ||
| - | **[[6ilh]] - hLysRS (mutant)<br /> | + | **[[6ilh]], [[7ea9]] - hLysRS (mutant)<br /> |
| + | **[[7f6w]] – yLysRS<br /> | ||
**[[1irx]] – PhLysRS<br /> | **[[1irx]] – PhLysRS<br /> | ||
**[[1bbw]] – EcLysRS<br /> | **[[1bbw]] – EcLysRS<br /> | ||
| Line 240: | Line 260: | ||
**[[1mkh]] – PabMetRS C-terminal<br /> | **[[1mkh]] – PabMetRS C-terminal<br /> | ||
**[[5xgq]] – MtMetRS<br /> | **[[5xgq]] – MtMetRS<br /> | ||
| - | **[[5h34]] – | + | **[[5h34]] – NeMetRS C-terminal – ''Nanoarchaeum equitans''<br /> |
**[[2x1l]] - MsMetRS residues 2-515 <br /> | **[[2x1l]] - MsMetRS residues 2-515 <br /> | ||
| + | **[[7wpj]] – SaMetRS<br /> | ||
* ''Met-RS + small substrates or analogs'' | * ''Met-RS + small substrates or analogs'' | ||
| + | |||
**[[5goy]] – hMetRS residues 221-834 + Met<br /> | **[[5goy]] – hMetRS residues 221-834 + Met<br /> | ||
**[[3kfl]] – LmMetRS residues 206-747+ Met-adenylate - ''Leishmania major''<br /> | **[[3kfl]] – LmMetRS residues 206-747+ Met-adenylate - ''Leishmania major''<br /> | ||
| Line 266: | Line 288: | ||
**[[6cml]], [[6mes]] - TbMetRS residues 237-773 (mutant) + Met + inhibitor <br /> | **[[6cml]], [[6mes]] - TbMetRS residues 237-773 (mutant) + Met + inhibitor <br /> | ||
**[[4qrd]], [[4qre]] - SaMetRS + antibacterial<br /> | **[[4qrd]], [[4qre]] - SaMetRS + antibacterial<br /> | ||
| + | **[[7wpi]], [[7wpn]] - SaMetRS + inhibitor<br /> | ||
| + | **[[7wpk]] - SaMetRS + Met<br /> | ||
| + | **[[7wpl]] - SaMetRS + ATP<br /> | ||
| + | **[[7wpm]], [[7wpt]], [[7wpx]], [[7wq0]] - SaMetRS + inhibitor + ATP<br /> | ||
| + | **[[7ulz]] - PaMetRS + Met<br /> | ||
* ''Met-RS + tRNA'' | * ''Met-RS + tRNA'' | ||
| Line 298: | Line 325: | ||
**[[5tev]] - NgTrpRS <br /> | **[[5tev]] - NgTrpRS <br /> | ||
**[[4j76]] - PfTrpRS <br /> | **[[4j76]] - PfTrpRS <br /> | ||
| + | **[[7el8]] - MtTrpRS <br /> | ||
* ''Trp-RS + small substrates or analogs'' | * ''Trp-RS + small substrates or analogs'' | ||
| + | |||
**[[5ujj]] – hTrpRS + Trp-AMP<br /> | **[[5ujj]] – hTrpRS + Trp-AMP<br /> | ||
**[[2quh]] – hTrpRS + Trp<br /> | **[[2quh]] – hTrpRS + Trp<br /> | ||
| Line 311: | Line 340: | ||
**[[2ov4]] – BsTrpRS + adenosine tetraphosphate<br /> | **[[2ov4]] – BsTrpRS + adenosine tetraphosphate<br /> | ||
**[[1i6k]], [[1i6l]], [[1i6m]] – BsTrpRS + Trp-adenylate<br /> | **[[1i6k]], [[1i6l]], [[1i6m]] – BsTrpRS + Trp-adenylate<br /> | ||
| + | **[[1maw]], [[1m83]] - BsTrpRS + ATP<br /> | ||
| + | **[[1mb2]] - BsTrpRS + Trp<br /> | ||
| + | **[[7cms]] - BsTrpRS + antibiotic<br /> | ||
**[[1yid]], [[2a4m]] – DrTrpRS + ATP<br /> | **[[1yid]], [[2a4m]] – DrTrpRS + ATP<br /> | ||
**[[1yi8]], [[1yia]]– DrTrpRS + Trp<br /> | **[[1yi8]], [[1yia]]– DrTrpRS + Trp<br /> | ||
| - | **[[1maw]], [[1m83]] - BsTrpRS + ATP<br /> | ||
| - | **[[1mb2]] - BsTrpRS + Trp<br /> | ||
**[[1bks]] – StTrpRS + pyridoxal phosphate<br /> | **[[1bks]] – StTrpRS + pyridoxal phosphate<br /> | ||
**[[6ncr]] - CtTrpRS + Trp<br /> | **[[6ncr]] - CtTrpRS + Trp<br /> | ||
**[[5tew]] - NgTrpRS + Trp<br /> | **[[5tew]] - NgTrpRS + Trp<br /> | ||
**[[4j75]] - PfTrpRS + Trp-AMP<br /> | **[[4j75]] - PfTrpRS + Trp-AMP<br /> | ||
| + | **[[7elt]] - MtTrpRS + Trp-AMP<br /> | ||
**[[6dfu]] - TrpRS + Trp – ''Haemophilus influenzae''<br /> | **[[6dfu]] - TrpRS + Trp – ''Haemophilus influenzae''<br /> | ||
*''Trp-RS ternary complex'' | *''Trp-RS ternary complex'' | ||
| - | **[[5ekd]] – hTrpRS + ATP + | + | **[[5ekd]] – hTrpRS + ATP + antibiotic<br /> |
| - | **[[5dk4]] – BsTrpRS + ATP + | + | **[[5dk4]], [[7cki]] – BsTrpRS + ATP + antibiotic<br /> |
| + | **[[7eer]] – BsTrpRS + ATP + inhibitor<br /> | ||
**[[3fhj]], [[3ghd]], [[3fi0]] – BsTrpRS + Trp + AMP + Pi<br /> | **[[3fhj]], [[3ghd]], [[3fi0]] – BsTrpRS + Trp + AMP + Pi<br /> | ||
**[[1mau]] – BsTrpRS + Trp + ATP<br /> | **[[1mau]] – BsTrpRS + Trp + ATP<br /> | ||
**[[5v0i]] - EcTrpRS + Trp + AMP<br /> | **[[5v0i]] - EcTrpRS + Trp + AMP<br /> | ||
| + | **[[7ens]] – MtTrpRS + ATP + antibiotic<br /> | ||
| + | **[[7ent]], [[7ev2]], [[7ev3]] – MtTrpRS + ATP + inhibitor<br /> | ||
* ''Trp-RS + tRNA'' | * ''Trp-RS + tRNA'' | ||
| + | |||
**[[2ake]], [[2dr2]] - hTrpRS + Trp-tRNA<br /> | **[[2ake]], [[2dr2]] - hTrpRS + Trp-tRNA<br /> | ||
**[[2azx]] – hTrpRS (mutant) + tRNA<br /> | **[[2azx]] – hTrpRS (mutant) + tRNA<br /> | ||
| Line 341: | Line 376: | ||
**[[1tya]], [[1tyb]], [[1tyc]], [[1tyd]], [[2ts1]] – BsTyrRS<br /> | **[[1tya]], [[1tyb]], [[1tyc]], [[1tyd]], [[2ts1]] – BsTyrRS<br /> | ||
**[[1jh3]] – BsTyrRS C-terminal – NMR<br /> | **[[1jh3]] – BsTyrRS C-terminal – NMR<br /> | ||
| - | **[[3qe4]], [[3d6u]], [[3d6v]], [[2pxh]], [[2hgz]], [[1u7d]], [[5n5v]], [[5nsf]] – MjTyrRS – ''Methanocaldococcus jannaschii''<br /> | + | **[[3qe4]], [[3d6u]], [[3d6v]], [[2pxh]], [[2hgz]], [[1u7d]], [[5n5v]], [[5nsf]], [[7c5c]], [[7ckh]] – MjTyrRS – ''Methanocaldococcus jannaschii''<br /> |
**[[1u7x]], [[4hjr]], [[4hk4]], [[5u36]], [[5l7p]] - MjTyrRS (mutant) <br /> | **[[1u7x]], [[4hjr]], [[4hk4]], [[5u36]], [[5l7p]] - MjTyrRS (mutant) <br /> | ||
**[[2jan]] – MtTyrRS<br /> | **[[2jan]] – MtTyrRS<br /> | ||
| Line 352: | Line 387: | ||
**[[2ktl]] - AnTyrRS C-terminal - NMR<br /> | **[[2ktl]] - AnTyrRS C-terminal - NMR<br /> | ||
**[[5ijx]] - TyrRS – ''Coccidiodides posadasii''<br /> | **[[5ijx]] - TyrRS – ''Coccidiodides posadasii''<br /> | ||
| + | **[[7fg6]] - NeTyrRS <br /> | ||
* ''Tyr-RS + small substrates or analogs'' | * ''Tyr-RS + small substrates or analogs'' | ||
| + | |||
**[[1q11]] – hTyrRS residues 1-364 + Tyr-ol<br /> | **[[1q11]] – hTyrRS residues 1-364 + Tyr-ol<br /> | ||
**[[2pid]] – hTyrRS residues 28-375 + Tyr-SA<br /> | **[[2pid]] – hTyrRS residues 28-375 + Tyr-SA<br /> | ||
| Line 359: | Line 396: | ||
**[[4qbt]] - hTyrRS + Tyr<br /> | **[[4qbt]] - hTyrRS + Tyr<br /> | ||
**[[3zxi]] - hTyrRS + Tyr-adenylate analog<br /> | **[[3zxi]] - hTyrRS + Tyr-adenylate analog<br /> | ||
| + | **[[7rou]] – hTyrRS + Tyr derivative<br /> | ||
**[[3ts1]] – BsTyrRS + Tyr-adenylate intermediate<br /> | **[[3ts1]] – BsTyrRS + Tyr-adenylate intermediate<br /> | ||
**[[4ts1]] – BsTyrRS + Tyr<br /> | **[[4ts1]] – BsTyrRS + Tyr<br /> | ||
| Line 365: | Line 403: | ||
**[[2zp1]] – MjTyrRS (mutant) + Tyr<br /> | **[[2zp1]] – MjTyrRS (mutant) + Tyr<br /> | ||
**[[1zh0]] - MjTyrRS (mutant) + naphthyl-Ala<br /> | **[[1zh0]] - MjTyrRS (mutant) + naphthyl-Ala<br /> | ||
| - | **[[1zh6]], [[2ag6]], [[4pbr]] - MjTyrRS (mutant) + Phe derivative<br /> | + | **[[1zh6]], [[2ag6]], [[4pbr]], [[7ckg]] - MjTyrRS (mutant) + Phe derivative<br /> |
**[[4hjx]] - MjTyrRS (mutant) + di-fluoro-Tyr<br /> | **[[4hjx]] - MjTyrRS (mutant) + di-fluoro-Tyr<br /> | ||
**[[4nx2]] - MjTyrRS (mutant) + di-chloro-Tyr<br /> | **[[4nx2]] - MjTyrRS (mutant) + di-chloro-Tyr<br /> | ||
| Line 387: | Line 425: | ||
**[[1jii]], [[1jij]], [[1jil]], [[1jik]] – SaTyrRS + inhibitor <br /> | **[[1jii]], [[1jij]], [[1jil]], [[1jik]] – SaTyrRS + inhibitor <br /> | ||
**[[6otj]] – NgTyrRS + Tyr<br /> | **[[6otj]] – NgTyrRS + Tyr<br /> | ||
| + | **[[7ror]] – PfTyrRS + Tyr-AMP<br /> | ||
| + | **[[7ros]] – PfTyrRS + Tyr derivative<br /> | ||
| + | **[[7rot]] – PfTyrRS (mutant) + Tyr derivative<br /> | ||
* ''Tyr-RS + tRNA'' | * ''Tyr-RS + tRNA'' | ||
| Line 394: | Line 435: | ||
**[[1h3e]] - TtTyrRS + Tyr-tRNA + Tyr-ol + ATP<br /> | **[[1h3e]] - TtTyrRS + Tyr-tRNA + Tyr-ol + ATP<br /> | ||
**[[2rkj]] – NcTyrRS + RNA<br /> | **[[2rkj]] – NcTyrRS + RNA<br /> | ||
| + | **[[7sc6]], [[7scq]] – TyrRS + RNA – ''Phaseolus vulgaris''<br /> | ||
*'''3-nitroTyr-RS''' | *'''3-nitroTyr-RS''' | ||
| Line 453: | Line 495: | ||
* ''Asp-RS + small substrates or analogs'' | * ''Asp-RS + small substrates or analogs'' | ||
| + | |||
**[[3nel]] – TkAspRS + Asp<br /> | **[[3nel]] – TkAspRS + Asp<br /> | ||
**[[3nem]] - TkAspRS + Asp-adenylate<br /> | **[[3nem]] - TkAspRS + Asp-adenylate<br /> | ||
| Line 484: | Line 527: | ||
* ''Asn-RS + small substrates or analogs'' | * ''Asn-RS + small substrates or analogs'' | ||
| + | |||
**[[2xti]] – BmAsnRS catalytic fragment + Asn-adenine analog<br /> | **[[2xti]] – BmAsnRS catalytic fragment + Asn-adenine analog<br /> | ||
**[[2xgt]] - BmAsnRS catalytic fragment + Asn-SA<br /> | **[[2xgt]] - BmAsnRS catalytic fragment + Asn-SA<br /> | ||
| Line 503: | Line 547: | ||
* ''Gly-RS + small substrates or analogs'' | * ''Gly-RS + small substrates or analogs'' | ||
| + | |||
**[[2zt5]], [[2zxf]] – hGlyRS residues 55-739 + bis-adenosine tetraphosphate<br /> | **[[2zt5]], [[2zxf]] – hGlyRS residues 55-739 + bis-adenosine tetraphosphate<br /> | ||
**[[2zt6]] - hGlyRS residues 55-739 + AMPCPP<br /> | **[[2zt6]] - hGlyRS residues 55-739 + AMPCPP<br /> | ||
| Line 511: | Line 556: | ||
**[[5f5w]] - AaGlyRS + Gly-adenylate<br /> | **[[5f5w]] - AaGlyRS + Gly-adenylate<br /> | ||
**[[3ufg]] - CjGlyRS + ATP<br /> | **[[3ufg]] - CjGlyRS + ATP<br /> | ||
| + | **[[7eiv]] - EcGlyRS + ANP + Gly<br /> | ||
* ''Gly-RS + tRNA'' | * ''Gly-RS + tRNA'' | ||
| Line 530: | Line 576: | ||
* ''His-RS + small substrates or analogs'' | * ''His-RS + small substrates or analogs'' | ||
| + | |||
**[[4phc]] - hHisRS + His <br /> | **[[4phc]] - hHisRS + His <br /> | ||
**[[3lc0]] – TcHisRS residues 45-478 + His – ''Trypanosoma cruzi''<br /> | **[[3lc0]] – TcHisRS residues 45-478 + His – ''Trypanosoma cruzi''<br /> | ||
| Line 542: | Line 589: | ||
**[[3hrk]] - TbHisRS + His-adenylate<br /> | **[[3hrk]] - TbHisRS + His-adenylate<br /> | ||
**[[2el9]] - EcHisRS + His-SA<br /> | **[[2el9]] - EcHisRS + His-SA<br /> | ||
| - | **[[1kmm]], 1ady]] - EcHisRS + His-adenylate<br /> | + | **[[1kmm]], [[1ady]] - EcHisRS + His-adenylate<br /> |
**[[1kmn]] - EcHisRS + His-ol + ATP<br /> | **[[1kmn]] - EcHisRS + His-ol + ATP<br /> | ||
**[[5e3i]] - AbHisRS + His + ATP<br /> | **[[5e3i]] - AbHisRS + His + ATP<br /> | ||
| Line 558: | Line 605: | ||
**[[7daw]] – MtPheRS + α+β chains <br /> | **[[7daw]] – MtPheRS + α+β chains <br /> | ||
**[[6p24]] – EcPheRS + α+β chains <br /> | **[[6p24]] – EcPheRS + α+β chains <br /> | ||
| + | **[[7n8y]] - SePheRS + chains – ''Salmonella enterica''<br /> | ||
* ''Phe-RS + small substrates or analogs'' | * ''Phe-RS + small substrates or analogs'' | ||
| + | |||
**[[3hfv]] – hPheRS + Tyr<br /> | **[[3hfv]] – hPheRS + Tyr<br /> | ||
**[[3teg]] – hPheRS + L-DOPA<br /> | **[[3teg]] – hPheRS + L-DOPA<br /> | ||
| Line 574: | Line 623: | ||
**[[7db7]], [[7db8]] – MtPheRS α+β chains + inhibitor<br /> | **[[7db7]], [[7db8]] – MtPheRS α+β chains + inhibitor<br /> | ||
**[[6p8t]] – AbPheRS α+β chains + inhibitor<br /> | **[[6p8t]] – AbPheRS α+β chains + inhibitor<br /> | ||
| + | **[[7dpi]] – PfPheRS + α+β chains + inhibitor<br /> | ||
* ''Phe-RS + tRNA'' | * ''Phe-RS + tRNA'' | ||
| + | |||
**[[3tup]] – hPheRS + Phe-tRNA<br /> | **[[3tup]] – hPheRS + Phe-tRNA<br /> | ||
**[[1eiy]] - TtPheRS α+β chains + Phe-tRNA<br /> | **[[1eiy]] - TtPheRS α+β chains + Phe-tRNA<br /> | ||
**[[2iy5]] - TtPheRS α+β chains + Phe-ol + Phe-tRNA<br /> | **[[2iy5]] - TtPheRS α+β chains + Phe-ol + Phe-tRNA<br /> | ||
| + | **[[7k98]], [[7k9m]], [[7ka0]] - MtPheRS + chains + Phe-tRNA + Phe-AMS<br /> | ||
| + | **[[7kab]] - MtPheRS + chains + Phe-tRNA + Phe<br /> | ||
*'''Pro-RS''' | *'''Pro-RS''' | ||
| Line 592: | Line 645: | ||
* ''Pro-RS + small substrates or analogs'' | * ''Pro-RS + small substrates or analogs'' | ||
| + | |||
**[[3ial]] – GlProRS residues 34-542 + Pro-adenylate<br /> | **[[3ial]] – GlProRS residues 34-542 + Pro-adenylate<br /> | ||
**[[2i4m]], [[2i4n]] – RpProRS + aa-SA<br /> | **[[2i4m]], [[2i4n]] – RpProRS + aa-SA<br /> | ||
| Line 599: | Line 653: | ||
**[[1h4t]] - TtProRS + Pro<br /> | **[[1h4t]] - TtProRS + Pro<br /> | ||
**[[5ifu]] – PfProRS residues 249-746 + glyburide <br /> | **[[5ifu]] – PfProRS residues 249-746 + glyburide <br /> | ||
| - | **[[4wi1]] – PfProRS residues 249-746 + inhibitor<br /> | + | **[[4wi1]], [[6t7k]], [[7qc1]] – PfProRS residues 249-746 + inhibitor<br /> |
*''Pro-RS ternary complex'' | *''Pro-RS ternary complex'' | ||
| + | |||
**[[4k87]] – hProRS residues 1000-1512 + proline + adenosine<br /> | **[[4k87]] – hProRS residues 1000-1512 + proline + adenosine<br /> | ||
**[[4k88]] – hProRS residues 1000-1512 + halofunginone<br /> | **[[4k88]] – hProRS residues 1000-1512 + halofunginone<br /> | ||
| Line 615: | Line 670: | ||
**[[6uyh]] – NfProRS + halofuginone + ANP <br /> | **[[6uyh]] – NfProRS + halofuginone + ANP <br /> | ||
**[[5xiq]] – TgProRS residues 334-830 + halofuginone + ANP <br /> | **[[5xiq]] – TgProRS residues 334-830 + halofuginone + ANP <br /> | ||
| + | **[[7evu]], [[7f9u]], [[7f9v]] – TgProRS residues 215-711 + halofuginone + inhibitor <br /> | ||
| + | **[[7f9r]] – TgProRS residues 215-711 + febrifugine + inhibitor + Pro<br /> | ||
| + | **[[7evv]], [[7fal]] – TgProRS residues 215-711 + inhibitor + Pro <br /> | ||
**[[5xik]], [[6a88]] – TgProRS residues 334-830 + febrifugine derivative + ANP <br /> | **[[5xik]], [[6a88]] – TgProRS residues 334-830 + febrifugine derivative + ANP <br /> | ||
**[[5xig]], [[5xih]], [[5xij]] – TgProRS residues 334-830 + inhibitor + ANP <br /> | **[[5xig]], [[5xih]], [[5xij]] – TgProRS residues 334-830 + inhibitor + ANP <br /> | ||
**[[5xii]] – TgProRS residues 334-830 (mutant) + inhibitor + ANP <br /> | **[[5xii]] – TgProRS residues 334-830 (mutant) + inhibitor + ANP <br /> | ||
**[[4ydq]], [[4q15]], [[4olf]] – PfProRS residues 254-746 + halofuginone + AMPPNP <br /> | **[[4ydq]], [[4q15]], [[4olf]] – PfProRS residues 254-746 + halofuginone + AMPPNP <br /> | ||
| - | **[[ | + | **[[7qb7]], [[7qc2]] – PfProRS residues 249-746 + inhibitor + Pro <br /> |
*'''Bifunctional RS''' (bifunctional glutamate/proline tRNA ligase) | *'''Bifunctional RS''' (bifunctional glutamate/proline tRNA ligase) | ||
| Line 626: | Line 684: | ||
**[[5v58]] – hGlu/ProRS residues 1003-1513 + AZ-SA<br /> | **[[5v58]] – hGlu/ProRS residues 1003-1513 + AZ-SA<br /> | ||
**[[5vad]] – hGlu/ProRS residues 1003-1513 + inhibitor<br /> | **[[5vad]] – hGlu/ProRS residues 1003-1513 + inhibitor<br /> | ||
| - | **[[5a1n]], [[5a34]], [[5a5h]] – hGlu/ProRS GST-like domain + EPRS-AIMP2<br /> | + | **[[7osy]] – hGlu/ProRS residues 1003-1513 + Pro<br /> |
| - | **[[1fyj]] – hGlu/ProRS 677-733 – NMR<br /> | + | **[[7bbu]], [[7f98]], [[7f99]], [[7f9a]], [[7f9b]], [[7f9c]], [[7f9d]], [[7osz]], [[7ot0]], [[7ot1]], [[7ot2]], [[7ot3]] – hGlu/ProRS residues 1003-1513 + inhibitor + Pro<br /> |
| + | **[[7x09]], [[7x1o]] – hGlu/ProRS residues 1003-1513 + inhibitor + halofuginone<br /> | ||
| + | **[[7y1w]], [[7y28]], [[7y3s]] – hGlu/ProRS residues 1003-1513 + inhibitor + ATP<br /> | ||
| + | **[[5a1n]], [[5a34]], [[5a5h]] – hGlu/ProRS GST-like domain 1-175 + EPRS-AIMP2<br /> | ||
| + | **[[1fyj]] – hGlu/ProRS 677-733 – NMR<br /> | ||
*'''Pyrrolysyl-RS'''; domains – RNA-binding 1-101; catalytic 188-454 | *'''Pyrrolysyl-RS'''; domains – RNA-binding 1-101; catalytic 188-454 | ||
| Line 635: | Line 697: | ||
**[[3dsq]] – DhPylRS<br /> | **[[3dsq]] – DhPylRS<br /> | ||
**[[6ezd]], [[6jp2]] – PylRS – ''Methanomethylophilus alvus''<br /> | **[[6ezd]], [[6jp2]] – PylRS – ''Methanomethylophilus alvus''<br /> | ||
| + | **[[7r6o]] - PylRS 1-273 – ''Methanogenic archaeon"<br /> | ||
*''Pyrrolysyl-RS binary complex'' | *''Pyrrolysyl-RS binary complex'' | ||
| Line 661: | Line 724: | ||
**[[6ly3]], [[6ly6]], [[6lyb]] - MmPylRS catalytic domain (mutant) + Ala derivative+ ANP <br /> | **[[6ly3]], [[6ly6]], [[6lyb]] - MmPylRS catalytic domain (mutant) + Ala derivative+ ANP <br /> | ||
**[[6ly7]], [[6lya]] - MmPylRS catalytic domain (mutant) + Trp derivative + ANP <br /> | **[[6ly7]], [[6lya]] - MmPylRS catalytic domain (mutant) + Trp derivative + ANP <br /> | ||
| + | **[[7rsm]] - MmPylRS catalytic domain (mutant) + Phe derivative + ANP <br /> | ||
**[[2zin]] - MmPylRS catalytic domain + butoxycarbonyl lysine + ATP analog <br /> | **[[2zin]] - MmPylRS catalytic domain + butoxycarbonyl lysine + ATP analog <br /> | ||
**[[6aac]], [[6aad]], [[6aao]], [[6aap]], [[6aaz]], [[6ab0]], [[6ab1]], [[6ab2]], [[6ab8]], [[6abk]], [[6abl]], [[6abm]], [[6aan]], [[6anq]] - MmPylRS catalytic domain + azanyl derivative + ATP <br /> | **[[6aac]], [[6aad]], [[6aao]], [[6aap]], [[6aaz]], [[6ab0]], [[6ab1]], [[6ab2]], [[6ab8]], [[6abk]], [[6abl]], [[6abm]], [[6aan]], [[6anq]] - MmPylRS catalytic domain + azanyl derivative + ATP <br /> | ||
| Line 716: | Line 780: | ||
**[[1y2q]] - PabThrRS editing domain 1-143<br /> | **[[1y2q]] - PabThrRS editing domain 1-143<br /> | ||
**[[1tje]] - EcThrRS editing domain 1-224<br /> | **[[1tje]] - EcThrRS editing domain 1-224<br /> | ||
| - | **[[7l3o]] - CpThrRS <br /> | + | **[[7l3o]] RBD 330-763 - CpThrRS <br /> |
* ''Thr-RS + small substrates or analogs'' | * ''Thr-RS + small substrates or analogs'' | ||
| Line 741: | Line 805: | ||
**[[4rrf]] - MjThrRS editing domain + Ser<br /> | **[[4rrf]] - MjThrRS editing domain + Ser<br /> | ||
**[[4rrg]] - MjThrRS editing domain + Thr<br /> | **[[4rrg]] - MjThrRS editing domain + Thr<br /> | ||
| - | **[[6l2q]] - | + | **[[6l2q]], [[7cbg]], [[7cbi]], [[7cbh]], [[7wm7]], [[7wmf]], [[7wmi]] - SeThrRS 222-622 + inhibitor <br /> |
* ''Thr-RS + tRNA'' | * ''Thr-RS + tRNA'' | ||
Current revision
3D Structures of Aminoacyl tRNA Synthetase
Updated on 24-September-2024
