User:Kylie Pfeifer/Sandbox1
From Proteopedia
< User:Kylie Pfeifer(Difference between revisions)
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=Human ''Sterol O-acyltransferase''= | =Human ''Sterol O-acyltransferase''= | ||
| - | <StructureSection load='6p2p' size=' | + | <StructureSection load='6p2p' size='350' frame='true' side='right' caption='ACAT/SOAT 6P2P' scene='87/877561/Areas_interest/4'> |
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==Introduction== | ==Introduction== | ||
| - | [[Image: | + | [[Image:6p2pS.png|400 px|right|thumb|Figure 1. Kylie]] Ransey Reference <ref name=”Ransey”>PMID:28504306</ref> |
== Function == | == Function == | ||
== Disease == | == Disease == | ||
| + | <scene name='87/877561/Areas_interest/3'>Different scene</scene> | ||
| + | SOAT Reference <ref name=”Guan”>PMID: 32424158</ref> | ||
== Relevance == | == Relevance == | ||
| + | ACAT Reference <ref name=”Qian”>PMID: 32433614</ref> | ||
== Structural highlights == | == Structural highlights == | ||
| + | [https://en.wikipedia.org/wiki/Tetramer Tetramer] | ||
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| + | <scene name='87/877561/Monomer/3'>monomer</scene> | ||
| + | <scene name='87/877561/C-tunnel/3'>C tunnel</scene> | ||
| + | <scene name='87/877561/T-tunnel/3'>T tunnel</scene> | ||
| + | <scene name='87/877561/L-tunnel/3'>L tunnel</scene> | ||
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| + | <scene name='87/877561/Ctunnel1/2'>C Tunnel</scene> | ||
| + | <scene name='87/877561/Ctunnel1/5'>C Tunnel Spin</scene> | ||
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| + | <scene name='87/877561/L-tunnel/4'>L Tunnel</scene> | ||
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| + | <scene name='87/877561/T-tunnel/4'>T Tunnel</scene> | ||
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| + | <scene name='87/877561/Ctunnel_final/1'>FINAL C</scene> | ||
| + | <scene name='87/877561/Ltunnel_final/1'>FINAL L</scene> | ||
| + | <scene name='87/877561/Ttunnel_final/1'>FINAL T</scene> | ||
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| + | Highly conserved residues Final: <scene name='87/877559/Important_residues_2_final/6'>highly conserved residues</scene> | ||
| + | <scene name='87/877561/Important_residues_2_final/1'>highly conserved residues</scene> | ||
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| + | W420, N421, and H460 Final: <scene name='87/877559/Important_residues_final/1'>W420, N421, and H460</scene> | ||
| + | <scene name='87/877561/Important_residues_final/1'>W420, N421, and H460</scene> | ||
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This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
Current revision
Human Sterol O-acyltransferase
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References
- ↑ Ransey E, Paredes E, Dey SK, Das SR, Heroux A, Macbeth MR. Crystal structure of the Entamoeba histolytica RNA lariat debranching enzyme EhDbr1 reveals a catalytic Zn(2+) /Mn(2+) heterobinucleation. FEBS Lett. 2017 Jul;591(13):2003-2010. doi: 10.1002/1873-3468.12677. Epub 2017, Jun 14. PMID:28504306 doi:http://dx.doi.org/10.1002/1873-3468.12677
- ↑ Guan C, Niu Y, Chen SC, Kang Y, Wu JX, Nishi K, Chang CCY, Chang TY, Luo T, Chen L. Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor. Nat Commun. 2020 May 18;11(1):2478. doi: 10.1038/s41467-020-16288-4. PMID:32424158 doi:http://dx.doi.org/10.1038/s41467-020-16288-4
- ↑ Qian H, Zhao X, Yan R, Yao X, Gao S, Sun X, Du X, Yang H, Wong CCL, Yan N. Structural basis for catalysis and substrate specificity of human ACAT1. Nature. 2020 May;581(7808):333-338. doi: 10.1038/s41586-020-2290-0. Epub 2020 May, 13. PMID:32433614 doi:http://dx.doi.org/10.1038/s41586-020-2290-0
Student Contributors
- Steph Pellegrino
- Kylie Pfeifer
- Kaitlyn Roberts
