User:Kaitlyn Roberts/Sandbox 1
From Proteopedia
< User:Kaitlyn Roberts(Difference between revisions)
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=Human ''Sterol O-acyltransferase''= | =Human ''Sterol O-acyltransferase''= | ||
| - | <StructureSection load='6p2p' size='350' frame='true' side='right' caption='Human ''Sterol O-acyltransferase''' scene=''> | + | <StructureSection load='6p2p' size='350' frame='true' side='right' caption='Human ''Sterol O-acyltransferase''' scene='87/877555/Active_site_residues/1'> |
==Introduction== | ==Introduction== | ||
| + | Sterol O-acyltransferase(SOAT), otherwise known as Acyl-coenzyme A:cholesterol acyltransferase(ACAT), is an enzyme that catalyzes the esterification of cholesterol for efficient storage within the cell. Cholesterol is a membrane lipid that plays an essential role in maintaining the fluidity and integrity of the membrane; and cholesteryl esters are formed when an excess of cholesterol is present. | ||
[[Image:Dimer side.png|400 px|right|thumb|Figure 1. The coolest image of this protein EVAH!!!]] | [[Image:Dimer side.png|400 px|right|thumb|Figure 1. The coolest image of this protein EVAH!!!]] | ||
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==Disease== | ==Disease== | ||
| - | This is bad <ref name= | + | This is bad <ref name="Guan">PMID:32424158</ref> |
==Relevance== | ==Relevance== | ||
| + | Really bad <ref name="Guan" /> | ||
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| + | <scene name='87/877559/Cholesterol/4'>Cholesterol Overview</scene> | ||
==Structural highlights== | ==Structural highlights== | ||
Here are the <scene name='87/877555/Active_site_residues/2'>active site residues</scene>. | Here are the <scene name='87/877555/Active_site_residues/2'>active site residues</scene>. | ||
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| + | This is <scene name='87/877555/As_residues/2'>oleoyl-CoA</scene> in the active site. | ||
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| + | Better view of the <scene name='87/877555/As_residues/1'>active site residues</scene>. | ||
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| + | <scene name='87/877555/As_residues/3'>h-bonding</scene> | ||
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| + | <scene name='87/877555/As_acylcoa_interaction/1'>H460, W420, and N421</scene> | ||
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| + | <scene name='87/877555/As_residues/4'>zoom out no main chain</scene> | ||
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| + | <scene name='87/877555/As_residues/5'>transition test</scene> | ||
</StructureSection> | </StructureSection> | ||
Current revision
Human Sterol O-acyltransferase
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References
- ↑ 1.0 1.1 Guan C, Niu Y, Chen SC, Kang Y, Wu JX, Nishi K, Chang CCY, Chang TY, Luo T, Chen L. Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor. Nat Commun. 2020 May 18;11(1):2478. doi: 10.1038/s41467-020-16288-4. PMID:32424158 doi:http://dx.doi.org/10.1038/s41467-020-16288-4
Student Contributors
- Kylie Pfifer
- Stepahnie Pellegrino
- Kaitlyn Roberts
