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6wsm
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==Crystal structure of coiled coil region of human septin 8== | ==Crystal structure of coiled coil region of human septin 8== | ||
| - | <StructureSection load='6wsm' size='340' side='right'caption='[[6wsm]]' scene=''> | + | <StructureSection load='6wsm' size='340' side='right'caption='[[6wsm]], [[Resolution|resolution]] 2.45Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WSM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WSM FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6wsm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WSM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WSM FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wsm OCA], [https://pdbe.org/6wsm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wsm RCSB], [https://www.ebi.ac.uk/pdbsum/6wsm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wsm ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.451Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wsm OCA], [https://pdbe.org/6wsm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wsm RCSB], [https://www.ebi.ac.uk/pdbsum/6wsm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wsm ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SEPT8_HUMAN SEPT8_HUMAN] Filament-forming cytoskeletal GTPase (By similarity). May play a role in platelet secretion (PubMed:15116257). Seems to participate in the process of SNARE complex formation in synaptic vesicles (By similarity).[UniProtKB:B0BNF1]<ref>PMID:15116257</ref> Stabilizes BACE1 protein levels and promotes the sorting and accumulation of BACE1 to the recycling or endosomal compartments, modulating the beta-amyloidogenic processing of APP.<ref>PMID:27084579</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Araujo APU]] | [[Category: Araujo APU]] | ||
Current revision
Crystal structure of coiled coil region of human septin 8
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