2h5x

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Current revision (09:52, 30 August 2023) (edit) (undo)
 
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<StructureSection load='2h5x' size='340' side='right'caption='[[2h5x]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='2h5x' size='340' side='right'caption='[[2h5x]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2h5x]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H5X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H5X FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2h5x]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H5X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H5X FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ruvA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h5x OCA], [https://pdbe.org/2h5x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h5x RCSB], [https://www.ebi.ac.uk/pdbsum/2h5x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h5x ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h5x OCA], [https://pdbe.org/2h5x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h5x RCSB], [https://www.ebi.ac.uk/pdbsum/2h5x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h5x ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/RUVA_MYCTU RUVA_MYCTU]] The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity).
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[https://www.uniprot.org/uniprot/RUVA_MYCTU RUVA_MYCTU] The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Myctu]]
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[[Category: Mycobacterium tuberculosis H37Rv]]
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[[Category: Alipio, E Z]]
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[[Category: Alipio EZ]]
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[[Category: Bursey, E]]
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[[Category: Bursey E]]
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[[Category: Chandra, N R]]
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[[Category: Chandra NR]]
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[[Category: Hung, L W]]
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[[Category: Hung LW]]
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[[Category: Khanduja, J S]]
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[[Category: Khanduja JS]]
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[[Category: Kim, C Y]]
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[[Category: Kim CY]]
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[[Category: Lekin, T]]
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[[Category: Lekin T]]
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[[Category: Muniyappa, K]]
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[[Category: Muniyappa K]]
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[[Category: Prabu, J R]]
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[[Category: Prabu JR]]
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[[Category: Segelke, B]]
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[[Category: Segelke B]]
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[[Category: Terwilliger, T C]]
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[[Category: Terwilliger TC]]
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[[Category: Thamotharan, S]]
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[[Category: Thamotharan S]]
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[[Category: Toppani, D]]
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[[Category: Toppani D]]
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[[Category: Vijayan, M]]
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[[Category: Vijayan M]]
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[[Category: Waldo, G S]]
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[[Category: Waldo GS]]
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[[Category: Yu, M]]
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[[Category: Yu M]]
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[[Category: Dna binding protein]]
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[[Category: Holliday junction binding]]
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[[Category: Recombination]]
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[[Category: Ruva]]
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Current revision

RuvA from Mycobacterium tuberculosis

PDB ID 2h5x

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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