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7m3q

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'''Unreleased structure'''
 
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The entry 7m3q is ON HOLD
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==Structure of the Smurf2 HECT Domain with a High Affinity Ubiquitin Variant (UbV)==
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<StructureSection load='7m3q' size='340' side='right'caption='[[7m3q]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7m3q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7M3Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7M3Q FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DTT:2,3-DIHYDROXY-1,4-DITHIOBUTANE'>DTT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7m3q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7m3q OCA], [https://pdbe.org/7m3q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7m3q RCSB], [https://www.ebi.ac.uk/pdbsum/7m3q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7m3q ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SMUF2_HUMAN SMUF2_HUMAN] E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Interacts with SMAD1 and SMAD7 in order to trigger their ubiquitination and proteasome-dependent degradation. In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with SCYE1. Forms a stable complex with the TGF-beta receptor-mediated phosphorylated SMAD2 and SMAD3. In this way, SMAD2 may recruit substrates, such as SNON, for ubiquitin-mediated degradation. Enhances the inhibitory activity of SMAD7 and reduces the transcriptional activity of SMAD2. Coexpression of SMURF2 with SMAD1 results in considerable decrease in steady-state level of SMAD1 protein and a smaller decrease of SMAD2 level.<ref>PMID:11389444</ref> <ref>PMID:12717440</ref>
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Authors: Chowdhury, A., Singer, A.U., Ogunjimi, A.A., Teyra, J., Zhang, W., Sicheri, F., Sidhu, S.S.
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==See Also==
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*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
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Description: Structure of the Smurf2 HECT Domain with a High Affinity Ubiquitin Variant (UbV)
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Sicheri, F]]
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__TOC__
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[[Category: Teyra, J]]
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</StructureSection>
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[[Category: Singer, A.U]]
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[[Category: Homo sapiens]]
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[[Category: Chowdhury, A]]
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[[Category: Large Structures]]
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[[Category: Zhang, W]]
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[[Category: Chowdhury A]]
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[[Category: Sidhu, S.S]]
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[[Category: Ogunjimi AA]]
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[[Category: Ogunjimi, A.A]]
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[[Category: Sicheri F]]
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[[Category: Sidhu SS]]
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[[Category: Singer AU]]
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[[Category: Teyra J]]
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[[Category: Zhang W]]

Current revision

Structure of the Smurf2 HECT Domain with a High Affinity Ubiquitin Variant (UbV)

PDB ID 7m3q

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OCA

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