6xg4
From Proteopedia
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==X-ray structure of Escherichia coli dihydrofolate reductase L28R mutant in complex with trimethoprim== | ==X-ray structure of Escherichia coli dihydrofolate reductase L28R mutant in complex with trimethoprim== | ||
| - | <StructureSection load='6xg4' size='340' side='right'caption='[[6xg4]]' scene=''> | + | <StructureSection load='6xg4' size='340' side='right'caption='[[6xg4]], [[Resolution|resolution]] 2.10Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XG4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XG4 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6xg4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XG4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XG4 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xg4 OCA], [https://pdbe.org/6xg4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xg4 RCSB], [https://www.ebi.ac.uk/pdbsum/6xg4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xg4 ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=TOP:TRIMETHOPRIM'>TOP</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xg4 OCA], [https://pdbe.org/6xg4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xg4 RCSB], [https://www.ebi.ac.uk/pdbsum/6xg4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xg4 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | ||
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| + | ==See Also== | ||
| + | *[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Escherichia coli K-12]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Borek D]] | [[Category: Borek D]] | ||
Current revision
X-ray structure of Escherichia coli dihydrofolate reductase L28R mutant in complex with trimethoprim
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