7bq5

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==ZIKV sE bound to mAb Z6==
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<StructureSection load='7bq5' size='340' side='right'caption='[[7bq5]]' scene=''>
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<StructureSection load='7bq5' size='340' side='right'caption='[[7bq5]], [[Resolution|resolution]] 2.99&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7bq5]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Zika_virus Zika virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BQ5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BQ5 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bq5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bq5 OCA], [https://pdbe.org/7bq5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bq5 RCSB], [https://www.ebi.ac.uk/pdbsum/7bq5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bq5 ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.99&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bq5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bq5 OCA], [https://pdbe.org/7bq5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bq5 RCSB], [https://www.ebi.ac.uk/pdbsum/7bq5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bq5 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Antibody-dependent enhancement (ADE) is an important safety concern for vaccine development against dengue virus (DENV) and its antigenically related Zika virus (ZIKV) because vaccine may prime deleterious antibodies to enhance natural infections. Cross-reactive antibodies targeting the conserved fusion loop epitope (FLE) are known as the main sources of ADE. We design ZIKV immunogens engineered to change the FLE conformation but preserve neutralizing epitopes. Single vaccination conferred sterilizing immunity against ZIKV without ADE of DENV-serotype 1-4 infections and abrogated maternal-neonatal transmission in mice. Unlike the wild-type-based vaccine inducing predominately cross-reactive ADE-prone antibodies, B cell profiling revealed that the engineered vaccines switched immunodominance to dispersed patterns without DENV enhancement. The crystal structure of the engineered immunogen showed the dimeric conformation of the envelope protein with FLE disruption. We provide vaccine candidates that will prevent both ZIKV infection and infection-/vaccination-induced DENV ADE.
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Protective Zika vaccines engineered to eliminate enhancement of dengue infection via immunodominance switch.,Dai L, Xu K, Li J, Huang Q, Song J, Han Y, Zheng T, Gao P, Lu X, Yang H, Liu K, Xia Q, Wang Q, Chai Y, Qi J, Yan J, Gao GF Nat Immunol. 2021 Aug;22(8):958-968. doi: 10.1038/s41590-021-00966-6. Epub 2021 , Jul 15. PMID:34267374<ref>PMID:34267374</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 7bq5" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Z-disk]]
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[[Category: Zika virus]]
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[[Category: Dai L]]
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[[Category: Gao GF]]
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[[Category: Qi J]]

Current revision

ZIKV sE bound to mAb Z6

PDB ID 7bq5

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