7jo7
From Proteopedia
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==Crystal Structure of Human Scribble PDZ2== | ==Crystal Structure of Human Scribble PDZ2== | ||
| - | <StructureSection load='7jo7' size='340' side='right'caption='[[7jo7]]' scene=''> | + | <StructureSection load='7jo7' size='340' side='right'caption='[[7jo7]], [[Resolution|resolution]] 2.44Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JO7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JO7 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7jo7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JO7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JO7 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jo7 OCA], [https://pdbe.org/7jo7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jo7 RCSB], [https://www.ebi.ac.uk/pdbsum/7jo7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jo7 ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.44Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jo7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jo7 OCA], [https://pdbe.org/7jo7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jo7 RCSB], [https://www.ebi.ac.uk/pdbsum/7jo7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jo7 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/SCRIB_HUMAN SCRIB_HUMAN] The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/SCRIB_HUMAN SCRIB_HUMAN] Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.<ref>PMID:15182672</ref> <ref>PMID:15775968</ref> <ref>PMID:16344308</ref> <ref>PMID:16965391</ref> <ref>PMID:18641685</ref> <ref>PMID:18716323</ref> <ref>PMID:19041750</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: How JY]] | [[Category: How JY]] | ||
[[Category: Kvansakul M]] | [[Category: Kvansakul M]] | ||
Current revision
Crystal Structure of Human Scribble PDZ2
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