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6vb9

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Current revision (08:08, 11 October 2023) (edit) (undo)
 
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<StructureSection load='6vb9' size='340' side='right'caption='[[6vb9]], [[Resolution|resolution]] 1.88&Aring;' scene=''>
<StructureSection load='6vb9' size='340' side='right'caption='[[6vb9]], [[Resolution|resolution]] 1.88&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6vb9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VB9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VB9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6vb9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VB9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6VB9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OXD:OXALIC+ACID'>OXD</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.881&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=QVA:'>QVA</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OXD:OXALIC+ACID'>OXD</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=QVA:(2S,3R)-2-{[(2R)-2-amino-2-carboxyethyl]sulfanyl}-3-hydroxybutanedioic+acid'>QVA</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">aceA_1, aceA, ERS007703_00218, ERS023446_00716, ERS027651_01707, EZX46_15490, FDK60_05445, FDK62_09180, SAMEA2682864_01056, SAMEA2683035_00941 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Isocitrate_lyase Isocitrate lyase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.1.3.1 4.1.3.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vb9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vb9 OCA], [https://pdbe.org/6vb9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vb9 RCSB], [https://www.ebi.ac.uk/pdbsum/6vb9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vb9 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6vb9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vb9 OCA], [https://pdbe.org/6vb9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6vb9 RCSB], [https://www.ebi.ac.uk/pdbsum/6vb9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6vb9 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ACEA_MYCTU ACEA_MYCTU] Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase-positive serine pathway (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Isocitrate lyase]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Krieger, I V]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Meek, T D]]
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[[Category: Krieger IV]]
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[[Category: Pham, T V]]
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[[Category: Meek TD]]
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[[Category: Sacchettini, J C]]
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[[Category: Pham TV]]
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[[Category: Structural genomic]]
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[[Category: Sacchettini JC]]
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[[Category: Covalent inhibitor]]
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[[Category: Enzyme]]
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[[Category: Lyase]]
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[[Category: Psi-biology]]
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[[Category: Substrate analog]]
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[[Category: Tbsgc]]
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Current revision

Covalent adduct of cis-2,3-epoxysuccinic acid with Isocitrate Lyase-1 from Mycobacterium tuberculosis

PDB ID 6vb9

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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