Aminopeptidase 3D structures

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*Alanine aminopeptidase or aminopeptidase N or a-aminoacylpeptide hydrolase
*Alanine aminopeptidase or aminopeptidase N or a-aminoacylpeptide hydrolase
 +
**[[8jkt]] – APN ectodomain 1-967 – cat<br />
**[[2hpo]], [[2dq6]], [[3puu]], [[6g8b]] – EcAPN - ''Escherichia coli''<br />
**[[2hpo]], [[2dq6]], [[3puu]], [[6g8b]] – EcAPN - ''Escherichia coli''<br />
**[[2gtq]] – NmAPN – ''Neisseria meningitides''<br />
**[[2gtq]] – NmAPN – ''Neisseria meningitides''<br />
**[[5dll]] – FtAPN - ''Francisella tularensis''<br />
**[[5dll]] – FtAPN - ''Francisella tularensis''<br />
-
**[[3ebg]] – PfAla-AP - ''Plasmodium falciparum''<br />
+
**[[3ebg]] – PfAla-APN - ''Plasmodium falciparum''<br />
**[[6oiu]] – APN – ''Toxoplasma gondii''<br />
**[[6oiu]] – APN – ''Toxoplasma gondii''<br />
*Alanine aminopeptidase binary complex
*Alanine aminopeptidase binary complex
-
**[[4fyq]], [[5lhd]] - hAla-AP + Zn<br />
+
**[[4fyq]], [[5lhd]] - hAla-APN + Zn<br />
-
**[[6u7e]], [[6u7f]], [[6u7g]] – hAPN + spike glycoprotein<br />
+
**[[6u7e]], [[6u7f]], [[6u7g]], [[7vpp]], [[7vpq]] – hAPN + spike glycoprotein<br />
**[[6xwd]], [[7aew]] – hAPN + 14-3-3 protein sigma<br />
**[[6xwd]], [[7aew]] – hAPN + 14-3-3 protein sigma<br />
-
**[[4fke]], [[5lds]], [[5lg6]], [[5z65]] – pAla-AP + Zn – pig<br />
+
**[[4fke]], [[5lds]], [[5lg6]], [[5z65]] – pAla-APN + Zn – pig<br />
 +
**[[7u0l]] – dAPN + spike glycoprotein - dog<br />
**[[3ked]] – EcAPN+2,4-diaminobutyric acid <br />
**[[3ked]] – EcAPN+2,4-diaminobutyric acid <br />
**[[2hpt]], [[2dqm]] – EcAPN+bestatin<br />
**[[2hpt]], [[2dqm]] – EcAPN+bestatin<br />
**[[2zxg]] – EcAPN+transition state analog<br />
**[[2zxg]] – EcAPN+transition state analog<br />
-
**[[3ebh]] - PfAla-AP+bestatin<br />
+
**[[8t83]] - PfAla-AP (mutant) + Zn<br />
-
**[[3ebi]] - PfAla-AP+dipeptide analog<br />
+
**[[3ebh]] - PfAla-APN+bestatin<br />
-
**[[4r5t]], [[4r5v]], [[4r5x]] – PfAla-AP + inhibitor <br />
+
**[[3ebi]] - PfAla-APN+dipeptide analog<br />
 +
**[[4r5t]], [[4r5v]], [[4r5x]] – PfAla-APN + inhibitor <br />
**[[5dyf]] – NmAPN + benzyl-diaminoethylphosphonate<br />
**[[5dyf]] – NmAPN + benzyl-diaminoethylphosphonate<br />
-
**[[4pu2]], [[4pvb]] – NmAP N + Leu analog <br />
+
**[[4pu2]], [[4pvb]] – NmAPN + Leu analog <br />
-
**[[4pw4]] – NmAP N + Phe analog <br />
+
**[[4pw4]] – NmAPN + Phe analog <br />
-
**[[4qhp]], [[4qir]], [[4qme]], [[4qpe]], [[4quo]] – NmAP N + dipeptide analog <br />
+
**[[4qhp]], [[4qir]], [[4qme]], [[4qpe]], [[4quo]] – NmAPN + dipeptide analog <br />
**[[4fgm]] – APN + Zn – ''Idiomarina loihiensis''<br />
**[[4fgm]] – APN + Zn – ''Idiomarina loihiensis''<br />
**[[5zi5]] – LpAPN + Zn – ''Legionella pneumophila''<br />
**[[5zi5]] – LpAPN + Zn – ''Legionella pneumophila''<br />
**[[5zi7]] – LpAPN + Glu<br />
**[[5zi7]] – LpAPN + Glu<br />
**[[5zie]] – LpAPN + Asp<br />
**[[5zie]] – LpAPN + Asp<br />
 +
**[[7v9n]], [[7v9o]], [[7v9p]], [[7v9q]] – APN + Zn – ''Saccharopolyspora erythrea''<br />
*Alanine aminopeptidase ternary complex
*Alanine aminopeptidase ternary complex
-
**[[4fyr]] - hAla-AP + Zn + bestatin<br />
+
**[[4fyr]] - hAla-APN + Zn + bestatin<br />
-
**[[4fys]] - hAla-AP + Zn + angiotensin<br />
+
**[[4fys]] - hAla-APN + Zn + angiotensin<br />
-
**[[4fyt]] - hAla-AP + Zn + amastatin<br />
+
**[[4fyt]] - hAla-APN + Zn + amastatin<br />
-
**[[4fkh]] – pAla-AP + Zn + Ala<br />
+
**[[4fkh]] – pAla-APN + Zn + Ala<br />
**[[6buy]], [[6bv0]], [[6bv1]], [[6bv2]], [[6bv3]], [[6bv4]] – pAPN+ Zn + amino acid<br />
**[[6buy]], [[6bv0]], [[6bv1]], [[6bv2]], [[6bv3]], [[6bv4]] – pAPN+ Zn + amino acid<br />
-
**[[4naq]], [[4nz8]], [[4ou3]] – pAla-AP + Zn + polypeptide<br />
+
**[[4naq]], [[4nz8]], [[4ou3]] – pAla-APN + Zn + polypeptide<br />
-
**[[4hom]] – pAla-AP + Zn + substance P<br />
+
**[[4hom]] – pAla-APN + Zn + substance P<br />
-
**[[4fkk]] – pAla-AP + Zn + bestatin<br />
+
**[[4fkk]] – pAla-APN + Zn + bestatin<br />
-
**[[4f5c]] – pAla-AP + PRCV spike protein + Zn<br />
+
**[[4f5c]] – pAla-APN + PRCV spike protein + Zn<br />
**[[3b2p]], [[3b2x]], [[3b34]], [[3b37]], [[3b3b]], [[3qjx]], [[4xo5]], [[4xo4]], [[4xo3]], [[4xnd]], [[4xnb]], [[4xna]], [[4xn9]], [[4xn8]], [[4xn7]], [[4xn5]], [[4xn4]], [[4xn2]], [[4xn1]], [[4xmz]], [[4xmx]], [[4xmw]], [[4xmv]], [[4xmu]], [[4xmt]], [[5yq1]] – EcAPN+ Zn + amino acid<br />
**[[3b2p]], [[3b2x]], [[3b34]], [[3b37]], [[3b3b]], [[3qjx]], [[4xo5]], [[4xo4]], [[4xo3]], [[4xnd]], [[4xnb]], [[4xna]], [[4xn9]], [[4xn8]], [[4xn7]], [[4xn5]], [[4xn4]], [[4xn2]], [[4xn1]], [[4xmz]], [[4xmx]], [[4xmw]], [[4xmv]], [[4xmu]], [[4xmt]], [[5yq1]] – EcAPN+ Zn + amino acid<br />
**[[4q4i]] – EcAPN+ Zn + peptide<br />
**[[4q4i]] – EcAPN+ Zn + peptide<br />
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**[[5yo1]] – EcAPN (mutant) + Zn + puromycin<br />
**[[5yo1]] – EcAPN (mutant) + Zn + puromycin<br />
**[[5yq2]] – EcAPN + Zn + puromycin aminonucleoside<br />
**[[5yq2]] – EcAPN + Zn + puromycin aminonucleoside<br />
 +
**[[8t41]] – MtAla-AP + Zn + Mg - ''Mycobacterium tuberculosis'' <br />
 +
**[[8t6h]] – PfAPN + Zn + Mg<br />
 +
**[[8t7p]] – PfAPN (mutant) + Zn + Mg<br />
*Aminopeptidase B
*Aminopeptidase B
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*Aminopeptidase C see [[Dipeptidyl aminopeptidase]]
*Aminopeptidase C see [[Dipeptidyl aminopeptidase]]
-
*Proline aminopeptidase or X-Pro aminopeptidase or aminopeptidase P or X-prolyl aminopeptidase
+
*Aminopeptidase M61
 +
 
 +
**[[7xyo]] – AP + Zn – ''Myxococcus fulvus''<br />
 +
 
 +
*Proline aminopeptidase or X-Pro aminopeptidase or aminopeptidase P or X-prolyl aminopeptidase or Xaa-Pro dipeptidase
**[[3ctz]] – X hPro-AP<br />
**[[3ctz]] – X hPro-AP<br />
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**[[1xqw]], [[1xqx]], [[1xqy]], [[1xrl]], [[1xrm]], [[1xrn]], [[1xro]], [[1xrp]], [[1xrq]], [[1xrr]] – TaPro-AP+polypeptide<br />
**[[1xqw]], [[1xqx]], [[1xqy]], [[1xrl]], [[1xrm]], [[1xrn]], [[1xro]], [[1xrp]], [[1xrq]], [[1xrr]] – TaPro-AP+polypeptide<br />
**[[3azq]] - SmoPro-AP (mutant) + PGG<br />
**[[3azq]] - SmoPro-AP (mutant) + PGG<br />
 +
**[[7e5c]] - Pro-AP (mutant) + Mn – ''Pseudoalteromonas lipolytica''<br />
*Proline aminopeptidase higher complex
*Proline aminopeptidase higher complex
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**[[1xry]], [[1txr]] – VpLeu-AP+bestatin<br />
**[[1xry]], [[1txr]] – VpLeu-AP+bestatin<br />
**[[3tc8]] - PdLeu-AP + Zn - ''Parabacteroides distasonis'' <br />
**[[3tc8]] - PdLeu-AP + Zn - ''Parabacteroides distasonis'' <br />
-
**[[4fuu]] - Leu-AP + Zn – ''Bacterioides thetaiotaomicron''<br />
+
**[[4fuu]] - BtLeu-AP + Zn – ''Bacterioides thetaiotaomicron''<br />
**[[5lhk]] – StrLeu-AP 2 + Mn <br />
**[[5lhk]] – StrLeu-AP 2 + Mn <br />
**[[4zla]], [[4zi6]] – Leu-AP + Zn – ''Helicobacter pylori'' <br />
**[[4zla]], [[4zi6]] – Leu-AP + Zn – ''Helicobacter pylori'' <br />
**[[5gne]], [[6esl]] – LpLeu-AP + Zn <br />
**[[5gne]], [[6esl]] – LpLeu-AP + Zn <br />
**[[6f3k]], [[6r8n]] – PhLeu-AP + Zn <br />
**[[6f3k]], [[6r8n]] – PhLeu-AP + Zn <br />
-
**[[6wvv]] – Leu-AP M17 + Zn – ''Plasmodium vivax''<br />
+
**[[6wvv]] – PvLeu-AP M17 + Zn – ''Plasmodium vivax''<br />
 +
**[[8sw9]] – PvLeu-AP M17 (mutant) + Zn<br />
 +
**[[7k5k]] – PvLeu-AP M17 + Mn<br />
 +
**[[7srv]], [[7t3v]] – PfLeu-AP + Zn <br />
*Leucine aminopeptidase ternary complex
*Leucine aminopeptidase ternary complex
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**[[1bpm]], [[1bpn]] – bLue-AP+Zn+Mg<br />
**[[1bpm]], [[1bpn]] – bLue-AP+Zn+Mg<br />
**[[2j9a]] - bLue-AP+Zn + inhibitor<br />
**[[2j9a]] - bLue-AP+Zn + inhibitor<br />
-
**[[3t8w]], [[4k3n]], [[4r6t]], [[6eee]] – PfLeu-AP + Zn + inhibitor <br />
+
**[[3t8w]], [[4k3n]], [[4r6t]], [[7rie]]] – PfLeu-AP + Zn + inhibitor <br />
**[[4r76]], [[4r7m]], [[4x2t]] – PfLeu-AP (mutant) + Zn + inhibitor <br />
**[[4r76]], [[4r7m]], [[4x2t]] – PfLeu-AP (mutant) + Zn + inhibitor <br />
**[[5ntd]] – TbLeu-AP + Mn + bestatin – ''Trypanosoma brucei''<br />
**[[5ntd]] – TbLeu-AP + Mn + bestatin – ''Trypanosoma brucei''<br />
-
**[[6ee2]], [[6eee]] - PfLue-AP M17 +Zn + inhibitor<br />
+
**[[6ee2]], [[6eee]], [[8ez4]] - PfLue-AP M17 +Zn + inhibitor<br />
 +
**[[7oez]] – AoLeu-AP + Zn + Leu – ''Aspergillus oryzae''<br />
 +
**[[7d1e]] - BtLeu-AP + Zn + acetylhistamine<br />
 +
**[[7y1s]] - BtLeu-AP + Zn + Ni – ''Bacillus amyloliquefaciens''<br />
-
*Leucine-cysteine aminopeptidase
+
*Leucine-cysteine aminopeptidase or insulin-regulated aminopeptidase
-
**[[4p8q]], [[5c97]], [[5mj6]] – hLeu-Cys-AP + Zn<br />
+
**[[4p8q]], [[5c97]], [[5mj6]], [[8p0i]] – hLeu-Cys-AP + Zn<br />
**[[4pj6]] – hLeu-Cys-AP + Zn + lysine<br />
**[[4pj6]] – hLeu-Cys-AP + Zn + lysine<br />
**[[4z7i]], [[6ydx]] – hLeu-Cys-AP + Zn + peptide<br />
**[[4z7i]], [[6ydx]] – hLeu-Cys-AP + Zn + peptide<br />
 +
**[[7zyf]] – hLeu-Cys-AP + Zn + inhibitor<br />
 +
**[[8cgp]], [[8cgw]] – hLeu-Cys-AP + Zn + malate<br />
*Lysine aminopeptidase
*Lysine aminopeptidase
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**[[4fuk]] – TbMet-AP + Zn<br />
**[[4fuk]] – TbMet-AP + Zn<br />
**[[6ksg]], [[6lh7]] – VcMet-AP + Ni<br />
**[[6ksg]], [[6lh7]] – VcMet-AP + Ni<br />
 +
**[[8onx]] – TtMet-AP + Mn – ''Thermochaetoides thermophila'' <br />
*Methionine aminopeptidase ternary complex
*Methionine aminopeptidase ternary complex
 +
**[[8bqd]], [[8bqx]] - yMet-AP 1 in ribosome – Cryo EM<br />
**[[3iu7]] – MtMet-AP+Mn +A02<br />
**[[3iu7]] – MtMet-AP+Mn +A02<br />
**[[3iu8]], [[3iu9]] - MtMet-AP+Ni + inhibitor<br />
**[[3iu8]], [[3iu9]] - MtMet-AP+Ni + inhibitor<br />
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**[[4if7]] - MtMet-AP+K + homocysteinemethyl disulfide<br />
**[[4if7]] - MtMet-AP+K + homocysteinemethyl disulfide<br />
**[[5ypd]], [[5yoh]], [[5yoi]], [[5yxf]] – MtMet-AP (mutant) + Co + Met<br />
**[[5ypd]], [[5yoh]], [[5yoi]], [[5yxf]] – MtMet-AP (mutant) + Co + Met<br />
-
**[[3d27]], [[2q92]], [[2q93]], [[2q94]], [[2q95]], [[2q96]] ,[[2p98]] [[2p99]], [[2p9a]], [[2gu4]], [[2gu5]], [[2gu6]], [[2evc]], [[2evm]], [[2evo]], [[2bbv]], [[1xnz]], [[4a6v]], [[4a6w]], [[2bb7]] – EcMet-AP+Mn+inhibitor<br />
+
**[[1xng]], [[2bb7]], [[2bbv]], [[2evc]], [[2evm]], [[2evo]], [[2gu4]], [[2gu5]], [[2gu6]], ,[[2p98]] [[2p99]], [[2p9a]], [[2q92]], [[2q93]], [[2q94]], [[2q95]], [[2q96]], [[3d27]], [[4a6v]], [[4a6w]], [[8oxg]] – EcMet-AP+Mn+inhibitor<br />
**[[2gg0]], [[2gg2]], [[2gg3]], [[2gg5]], [[2gg7]], [[2gg8]], [[2gg9]], [[2ggb]], [[2ggc]], [[4pnc]] - EcMet-AP+Co+inhibitor<br />
**[[2gg0]], [[2gg2]], [[2gg3]], [[2gg5]], [[2gg7]], [[2gg8]], [[2gg9]], [[2ggb]], [[2ggc]], [[4pnc]] - EcMet-AP+Co+inhibitor<br />
**[[1c21]], [[1c22]], [[1c23]], [[1c24]] - EcMet-AP +Co + methionine derivative<br />
**[[1c21]], [[1c22]], [[1c23]], [[1c24]] - EcMet-AP +Co + methionine derivative<br />
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**[[1yvm]] – EcMet-AP (mutant)+Co+thiabendazole<br />
**[[1yvm]] – EcMet-AP (mutant)+Co+thiabendazole<br />
**[[3mat]] - EcMet-AP (mutant)+Co+bestatin derivative<br />
**[[3mat]] - EcMet-AP (mutant)+Co+bestatin derivative<br />
 +
**[[8onz]], [[8oo0]] - TtMet-AP 2 in ribosome – Cryo EM<br />
*Human methionine aminopeptidase
*Human methionine aminopeptidase
-
**[[2b3h]], [[2b3k]] - hMet-AP 1 + Co<br />
+
**[[8p2k]], [[9f1c]], [[9f1d]], [[9fpz]], [[9fq0]] - hMet-AP 1 in ribosome – Cryo EM<br />
 +
**[[8khm]] - hMet-AP 1 <br />
 +
**[[2b3h]], [[2b3k]], [[8knh]] - hMet-AP 1 + Co<br />
**[[5yr7]] – hMet-AP 1 (mutant) + Co<br />
**[[5yr7]] – hMet-AP 1 (mutant) + Co<br />
**[[2gz5]], [[4ikr]], [[4iks]], [[4ikt]], [[4iku]], [[4hxx]], [[4iu6]], [[6lzb]], [[6lzc]] –, hMet-AP 1 + Co + inhibitor<br />
**[[2gz5]], [[4ikr]], [[4iks]], [[4ikt]], [[4iku]], [[4hxx]], [[4iu6]], [[6lzb]], [[6lzc]] –, hMet-AP 1 + Co + inhibitor<br />
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**[[4dyo]] – hAsp-AP+aspartic hydroxamate<br />
**[[4dyo]] – hAsp-AP+aspartic hydroxamate<br />
**[[3var]], [[3vat]] – bAsp-AP<br />
**[[3var]], [[3vat]] – bAsp-AP<br />
 +
**[[7u5h]] – bAsp-AP + Zn – Cryo EM<br />
**[[4eme]], [[6pev]] – PfAsp-AP + Zn<br />
**[[4eme]], [[6pev]] – PfAsp-AP + Zn<br />
Line 274: Line 300:
**[[2yd0]] – hARTS-1 soluble domain 46-940<br />
**[[2yd0]] – hARTS-1 soluble domain 46-940<br />
**[[6mgq]], [[6q4r]], [[6rqx]], [[6ryf]] – hARTS-1 + phosphinic inhibitor<br />
**[[6mgq]], [[6q4r]], [[6rqx]], [[6ryf]] – hARTS-1 + phosphinic inhibitor<br />
 +
**[[7mwb]], [[7mwc]] – hARTS-1 + peptide<br />
**[[3mdj]], [[6m8p]], [[6mgq]] – hARTS-1 + Zn + inhibitor<br />
**[[3mdj]], [[6m8p]], [[6mgq]] – hARTS-1 + Zn + inhibitor<br />
**[[6t6r]] – hARTS-1 (mutant) + Zn + inhibitor<br />
**[[6t6r]] – hARTS-1 (mutant) + Zn + inhibitor<br />
**[[3se6]], [[5cu5]] – hARTS-2<br />
**[[3se6]], [[5cu5]] – hARTS-2<br />
**[[4e36]] – hARTS-2 (mutant) + Zn<br />
**[[4e36]] – hARTS-2 (mutant) + Zn<br />
-
**[[4jbs]], [[5k1v]], [[5j6s]], [[6ea4]] – hARTS-2 + Zn + inhibitor<br />
+
**[[4jbs]], [[5k1v]], [[5j6s]], [[6ea4]], [[7nsk]], [[7nup]], [[7p7p]], [[7pfs]], [[7sh0]], [[7z28]] – hARTS-2 + Zn + inhibitor<br />
-
**[[5ab2]], [[5ab0]] – hARTS-2 + Zn + peptide<br />
+
**[[5ab0]], [[5ab2]] – hARTS-2 + Zn + peptide<br />
 +
 
 +
*Puromycin-sensitive aminopeptidase
 +
 
 +
**[[8sw0]] – hAP + Zn<br />
 +
**[[8sw1]] – hAP + peptide + Zn<br />
*Non-specific aminopeptidase
*Non-specific aminopeptidase
Line 340: Line 372:
**[[5y1x]] - PfLeu-AP + Zn + Mg + actinonin<br />
**[[5y1x]] - PfLeu-AP + Zn + Mg + actinonin<br />
**[[4k5l]], [[4k5m]], [[4k5n]], [[4k5p]], [[4k5o]], [[5cbm]] - PfLeu-AP (mutant) + Zn + inhibitor<br />
**[[4k5l]], [[4k5m]], [[4k5n]], [[4k5p]], [[4k5o]], [[5cbm]] - PfLeu-AP (mutant) + Zn + inhibitor<br />
-
**[[5xm7]], [[5y19]], [[5y1h]], [[5y1k]], [[5y1q]], [[5y1r]], [[5y1s]], [[5y1t]], [[5y1v]], [[5y3i]] - PfLeu-AP + Zn + Mg + inhibitor<br />
+
**[[5xm7]], [[5y19]], [[5y1h]], [[5y1k]], [[5y1q]], [[5y1r]], [[5y1s]], [[5y1t]], [[5y1v]], [[5y3i]], [[8ex3]], [[8ez2]], [[8svl]] - PfLeu-AP + Zn + Mg + inhibitor<br />
**[[4zx6]], [[4zx5]], [[4zx4]], [[4zx5]], [[4zx3]], [[4zw8]], [[4zw7]], [[4zw6]], [[4zw5]], [[4zw3]], [[4zqt]], [[4x2u]], [[6ea1]], [[6ea2]], [[6eaa]], [[6eab]], [[6ee3]], [[6ee4]], [[6ee6]], [[6eed]] - PfLeu-AP (mutant) + Zn + Mg + inhibitor<br />
**[[4zx6]], [[4zx5]], [[4zx4]], [[4zx5]], [[4zx3]], [[4zw8]], [[4zw7]], [[4zw6]], [[4zw5]], [[4zw3]], [[4zqt]], [[4x2u]], [[6ea1]], [[6ea2]], [[6eaa]], [[6eab]], [[6ee3]], [[6ee4]], [[6ee6]], [[6eed]] - PfLeu-AP (mutant) + Zn + Mg + inhibitor<br />
-
**[[6sbq]], [[6sbr]] - PfAla-AP + Zn + inhibitor<br />
+
**[[6sbq]], [[6sbr]], [[8ewz]], [[8eyd]], [[8eye]], [[8eyf]], [[8svm]], [[8svo]] - PfAla-AP + Zn + inhibitor<br />
**[[3q43]], [[3q44]] – PfAP (mutant) + bestatin derivative<br />
**[[3q43]], [[3q44]] – PfAP (mutant) + bestatin derivative<br />
}}
}}

Current revision

3D Structures of Aminopeptidase

Updated on 26-September-2024

Tripeptidyl aminotransferase see Tripeptidyl peptidase Dipeptidyl aminotransferase see Dipeptidyl peptidase

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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