7kyw
From Proteopedia
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==Crystal structure of timothy grass allergen Phl p 12.0101 reveals an unusual profilin dimer== | ==Crystal structure of timothy grass allergen Phl p 12.0101 reveals an unusual profilin dimer== | ||
| - | <StructureSection load='7kyw' size='340' side='right'caption='[[7kyw]]' scene=''> | + | <StructureSection load='7kyw' size='340' side='right'caption='[[7kyw]], [[Resolution|resolution]] 2.30Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KYW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KYW FirstGlance]. <br> | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KYW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KYW FirstGlance]. <br> | ||
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kyw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kyw OCA], [https://pdbe.org/7kyw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kyw RCSB], [https://www.ebi.ac.uk/pdbsum/7kyw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kyw ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kyw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kyw OCA], [https://pdbe.org/7kyw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kyw RCSB], [https://www.ebi.ac.uk/pdbsum/7kyw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kyw ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Timothy grass pollen is a source of potent allergens. Among them, Phl p 1 and Phl p 5 are thought to be the most important, as a majority of timothy grass-allergic individuals have IgE antibodies directed against these two allergens. The profilin from timothy grass (Phl p 12) has been registered as a minor allergen, with up to 35% of individuals in populations of grass pollen allergic patients showing IgE binding to Phl p 12. Profilins are primarily minor allergens and are known for a high likelihood of co-sensitization as well as cross-reactivity situations caused by their sequence and structure similarity. The crystal structure of Phl p 12.0101 was determined and it revealed that this allergen may form an unusual dimer not previously observed among any profilins. For example, the Phl p 12 dimer has a completely different geometry and interface when compared with the latex profilin (Hev b 8) dimer that has its crystal structure determined. The structure of Phl p 12.0101 is described in the context of allergenic sensitization and allergy diagnostics. Moreover, the structure of the Phl p 12.0101 dimer is discussed, taking into account the production of recombinant allergens and their storage. | ||
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| + | Crystal structure of timothy grass allergen Phl p 12.0101 reveals an unusual profilin dimer.,O'Malley A, Kapingidza AB, Hyduke N, Dolamore C, Kowal K, Chruszcz M Acta Biochim Pol. 2021 Mar 15;68(1):15-22. doi: 10.18388/abp.2020_5587. PMID:33720678<ref>PMID:33720678</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7kyw" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Profilin 3D Structures|Profilin 3D Structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Current revision
Crystal structure of timothy grass allergen Phl p 12.0101 reveals an unusual profilin dimer
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