7bzz

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Current revision (15:45, 29 November 2023) (edit) (undo)
 
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<StructureSection load='7bzz' size='340' side='right'caption='[[7bzz]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='7bzz' size='340' side='right'caption='[[7bzz]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7bzz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BZZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BZZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7bzz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BZZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BZZ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.501&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Scara5 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bzz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bzz OCA], [https://pdbe.org/7bzz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bzz RCSB], [https://www.ebi.ac.uk/pdbsum/7bzz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bzz ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bzz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bzz OCA], [https://pdbe.org/7bzz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bzz RCSB], [https://www.ebi.ac.uk/pdbsum/7bzz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bzz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/SCAR5_MOUSE SCAR5_MOUSE]] Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1).[HAMAP-Rule:MF_03070]<ref>PMID:19154717</ref>
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[https://www.uniprot.org/uniprot/SCAR5_MOUSE SCAR5_MOUSE] Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1).[HAMAP-Rule:MF_03070]<ref>PMID:19154717</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: He, Y]]
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[[Category: He Y]]
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[[Category: Yu, B]]
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[[Category: Yu B]]
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[[Category: Ferritin]]
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[[Category: Metal binding protein]]
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[[Category: Scara5]]
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[[Category: Scavenger receptor]]
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[[Category: Sr class some]]
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[[Category: Srcr]]
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Current revision

Crystal structure of the SRCR domain of mouse SCARA5

PDB ID 7bzz

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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