1gkn

From Proteopedia

(Difference between revisions)

Current revision

Structure Determination and Rational Mutagenesis reveal binding surface of immune adherence receptor, CR1 (CD35)

Structural highlights

1gkn is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR, 24 models
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CR1_HUMAN Mediates cellular binding of particles and immune complexes that have activated complement.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Complement receptor type 1 (CR1 or CD35) is a multiple modular protein that mediates the immune adherence phenomenon, a fundamental event for destroying microbes and initiating an immunological response. It fulfills this role through binding C3b/C4b-opsonized foreign antigens. The structure of the principal C3b/C4b binding site (residues 901-1095) of CR1 is reported, revealing three complement control protein modules (modules 15-17) in an extended head-to-tail arrangement with flexibility at the 16-17 junction. Structure-guided mutagenesis identified a positively charged surface region on module 15 that is critical for C4b binding. This patch, together with basic side chains of module 16 exposed on the same face of CR1, is required for C3b binding. These studies reveal the initial structural details of one of the first receptor-ligand interactions to be identified in immunobiology.

Structure of the C3b binding site of CR1 (CD35), the immune adherence receptor.,Smith BO, Mallin RL, Krych-Goldberg M, Wang X, Hauhart RE, Bromek K, Uhrin D, Atkinson JP, Barlow PN Cell. 2002 Mar 22;108(6):769-80. PMID:11955431^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Smith BO, Mallin RL, Krych-Goldberg M, Wang X, Hauhart RE, Bromek K, Uhrin D, Atkinson JP, Barlow PN. Structure of the C3b binding site of CR1 (CD35), the immune adherence receptor. Cell. 2002 Mar 22;108(6):769-80. PMID:11955431

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1gkn"

@@ Line 1: / Line 1: @@
 ==Structure Determination and Rational Mutagenesis reveal binding surface of immune adherence receptor, CR1 (CD35)==
-<StructureSection load='1gkn' size='340' side='right'caption='[[1gkn]], [[NMR_Ensembles_of_Models | 24 NMR models]]' scene=''>
+<StructureSection load='1gkn' size='340' side='right'caption='[[1gkn]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1gkn]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GKN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GKN FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1gkn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GKN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GKN FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1gkg|1gkg]]</div></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 24 models</td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gkn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gkn OCA], [https://pdbe.org/1gkn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gkn RCSB], [https://www.ebi.ac.uk/pdbsum/1gkn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gkn ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/CR1_HUMAN CR1_HUMAN] Mediates cellular binding of particles and immune complexes that have activated complement.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 12: / Line 14: @@
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gk/1gkn_consurf.spt"</scriptWhenChecked>
-    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
@@ Line 30: / Line 32: @@
 __TOC__
 </StructureSection>
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Atkinson, J P]]
+[[Category: Atkinson JP]]
-[[Category: Barlow, P N]]
+[[Category: Barlow PN]]
-[[Category: Bromek, K]]
+[[Category: Bromek K]]
-[[Category: Hauhart, R E]]
+[[Category: Hauhart RE]]
-[[Category: Krych-Goldberg, M]]
+[[Category: Krych-Goldberg M]]
-[[Category: Mallin, R L]]
+[[Category: Mallin RL]]
-[[Category: Smith, B O]]
+[[Category: Smith BO]]
-[[Category: Uhrin, D]]
+[[Category: Uhrin D]]
-[[Category: Wang, X]]
+[[Category: Wang X]]
-[[Category: Complement]]
-[[Category: Module]]
-[[Category: Scr]]

1gkn

From Proteopedia

Current revision

Structure Determination and Rational Mutagenesis reveal binding surface of immune adherence receptor, CR1 (CD35)

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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