7ehl

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'''Unreleased structure'''
 
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The entry 7ehl is ON HOLD
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==Cryo-EM structure of human ABCB8 transporter in nucleotide binding state==
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<StructureSection load='7ehl' size='340' side='right'caption='[[7ehl]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EHL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EHL FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ehl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ehl OCA], [https://pdbe.org/7ehl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ehl RCSB], [https://www.ebi.ac.uk/pdbsum/7ehl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ehl ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Human ATP-binding cassette transporter 8 of subfamily B (hABCB8) is an ABC transporter that located in the inner membrane of mitochondria. The ABCB8 is involved in the maturation of Fe-S and protects the heart from oxidative stress. Here, we present the cryo-EM structure of human ABCB8 binding with AMPPNP in inward-facing conformation with resolution of 4.1 A. hABCB8 shows an open-inward conformation when ATP is bound. Unexpectedly, cholesterol molecules were identified in the transmembrane domain of hABCB8. Our results provide structural basis for the transport mechanism of the ABC transporter in mitochondria.
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Authors:
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Cryo-EM structure of human ABCB8 transporter in nucleotide binding state.,Li S, Ren Y, Lu X, Shen Y, Yang X Biochem Biophys Res Commun. 2021 Apr 16;557:187-191. doi:, 10.1016/j.bbrc.2021.04.007. PMID:33872987<ref>PMID:33872987</ref>
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Description:
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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<div class="pdbe-citations 7ehl" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Li SJ]]
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[[Category: Shen YQ]]
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[[Category: Yang X]]

Current revision

Cryo-EM structure of human ABCB8 transporter in nucleotide binding state

PDB ID 7ehl

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