This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
7m0l
From Proteopedia
(Difference between revisions)
| (One intermediate revision not shown.) | |||
| Line 1: | Line 1: | ||
==HPK1 IN COMPLEX WITH COMPOUND 1== | ==HPK1 IN COMPLEX WITH COMPOUND 1== | ||
| - | <StructureSection load='7m0l' size='340' side='right'caption='[[7m0l]]' scene=''> | + | <StructureSection load='7m0l' size='340' side='right'caption='[[7m0l]], [[Resolution|resolution]] 2.43Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7M0L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7M0L FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7m0l]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7M0L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7M0L FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7m0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7m0l OCA], [https://pdbe.org/7m0l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7m0l RCSB], [https://www.ebi.ac.uk/pdbsum/7m0l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7m0l ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.43Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=YK4:4-(2-bromoanilino)-2-[(6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino]pyrimidine-5-carboxamide'>YK4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7m0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7m0l OCA], [https://pdbe.org/7m0l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7m0l RCSB], [https://www.ebi.ac.uk/pdbsum/7m0l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7m0l ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/M4K1_HUMAN M4K1_HUMAN] Serine/threonine-protein kinase, which may play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. May play a role in hematopoietic lineage decisions and growth regulation. Able to autophosphorylate.<ref>PMID:24362026</ref> <ref>PMID:8824585</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Lesburg CA]] | [[Category: Lesburg CA]] | ||
Current revision
HPK1 IN COMPLEX WITH COMPOUND 1
| |||||||||||
