7eki
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==human alpha 7 nicotinic acetylcholine receptor in apo-form== | |
| - | + | <StructureSection load='7eki' size='340' side='right'caption='[[7eki]], [[Resolution|resolution]] 3.18Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7eki]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EKI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EKI FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | |
| - | [[Category: | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CHRNA7, NACHRA7 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7eki FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7eki OCA], [https://pdbe.org/7eki PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7eki RCSB], [https://www.ebi.ac.uk/pdbsum/7eki PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7eki ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [[https://www.uniprot.org/uniprot/ACHA7_HUMAN ACHA7_HUMAN]] 15q13.3 microdeletion syndrome. | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/ACHA7_HUMAN ACHA7_HUMAN]] After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Human]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Liu, S]] | ||
| + | [[Category: Sun, D]] | ||
| + | [[Category: Tian, C]] | ||
| + | [[Category: Zhao, Y]] | ||
| + | [[Category: Alpha 7]] | ||
| + | [[Category: Apo-form]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Nicotinic acetylcholine receptor]] | ||
Current revision
human alpha 7 nicotinic acetylcholine receptor in apo-form
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