7bb4

<table><tr><td colspan='2'>[[7bb4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ccm_7076 Ccm 7076]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BB4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BB4 FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=FUL:BETA-L-FUCOSE'>FUL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CKY10_20885 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2218628 CCM 7076])</td></tr>

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== Publication Abstract from PubMed ==

Carbohydrate-binding proteins from pathogenic bacteria and fungi have been shown to be implicated in various pathological processes, where they interact with glycans present on the surface of the host cells. These interactions are part of the initial processes of infection of the host and are very important to study at the atomic level. Here, we report the room temperature neutron structures of PLL lectin from Photorhabdus laumondii in its apo form and in complex with deuterated L-fucose, which is, to our knowledge, the first neutron structure of a carbohydrate-binding protein in complex with a fully deuterated carbohydrate ligand. A detailed structural analysis of the lectin-carbohydrate interactions provides information on the hydrogen bond network, the role of water molecules, and the extent of the CH-pi stacking interactions between fucose and the aromatic amino acids in the binding site.

Visualization of hydrogen atoms in a perdeuterated lectin-fucose complex reveals key details of protein-carbohydrate interactions.,Gajdos L, Blakeley MP, Kumar A, Wimmerova M, Haertlein M, Forsyth VT, Imberty A, Devos JM Structure. 2021 Mar 24. pii: S0969-2126(21)00076-9. doi:, 10.1016/j.str.2021.03.003. PMID:33765407<ref>PMID:33765407</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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== References ==

<references/>

[[Category: Ccm 7076]]

[[Category: Blakeley, M P]]

[[Category: Devos, J M]]

[[Category: Forsyth, V T]]

[[Category: Gajdos, L]]

[[Category: Haertlein, M]]

[[Category: Imberty, A]]

[[Category: Kumar, A]]

[[Category: Wimmerova, M]]

[[Category: Sugar binding protein]]