2krb
From Proteopedia
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==Solution structure of EIF3B-RRM bound to EIF3J peptide== | ==Solution structure of EIF3B-RRM bound to EIF3J peptide== | ||
| - | <StructureSection load='2krb' size='340' side='right'caption='[[2krb | + | <StructureSection load='2krb' size='340' side='right'caption='[[2krb]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2krb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2krb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KRB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KRB FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2krb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2krb OCA], [https://pdbe.org/2krb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2krb RCSB], [https://www.ebi.ac.uk/pdbsum/2krb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2krb ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2krb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2krb OCA], [https://pdbe.org/2krb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2krb RCSB], [https://www.ebi.ac.uk/pdbsum/2krb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2krb ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/EIF3B_HUMAN EIF3B_HUMAN] Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.<ref>PMID:9388245</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Elantak | + | [[Category: Elantak L]] |
| - | [[Category: Herrmannova | + | [[Category: Herrmannova A]] |
| - | [[Category: Janoskova | + | [[Category: Janoskova M]] |
| - | [[Category: Lukavsky | + | [[Category: Lukavsky PJ]] |
| - | [[Category: Rutkai | + | [[Category: Rutkai E]] |
| - | [[Category: Valasek | + | [[Category: Valasek L]] |
| - | [[Category: Wagner | + | [[Category: Wagner S]] |
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Current revision
Solution structure of EIF3B-RRM bound to EIF3J peptide
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