2l2i

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NMR Structure of the complex between the Tfb1 subunit of TFIIH and the activation domain of EKLF

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 ==NMR Structure of the complex between the Tfb1 subunit of TFIIH and the activation domain of EKLF==
-<StructureSection load='2l2i' size='340' side='right'caption='[[2l2i]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+<StructureSection load='2l2i' size='340' side='right'caption='[[2l2i]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2l2i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast] and [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L2I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L2I FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2l2i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L2I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L2I FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">D9740.3, TFB1, YDR311W ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), EKLF, KLF1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l2i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l2i OCA], [https://pdbe.org/2l2i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l2i RCSB], [https://www.ebi.ac.uk/pdbsum/2l2i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l2i ProSAT]</span></td></tr>
 </table>
-== Disease ==
-[[https://www.uniprot.org/uniprot/KLF1_HUMAN KLF1_HUMAN]] Hereditary persistence of fetal hemoglobin - beta-thalassemia;Hereditary persistence of fetal hemoglobin - sickle cell disease;Congenital dyserythropoietic anemia due to KLF1 mutation. Congenital dyserythropoietic anemia 4 (CDA4) [MIM:[https://omim.org/entry/613673 613673]]: A blood disorder characterized by ineffective erythropoiesis and hemolysis resulting in anemia. Circulating erythroblasts and erythroblasts in the bone marrow show various morphologic abnormalities. Affected individuals with CDA4 also have increased levels of fetal hemoglobin. Note=The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:21055716</ref>
 == Function ==
-[[https://www.uniprot.org/uniprot/TFB1_YEAST TFB1_YEAST]] Acts as component of the general transcription and DNA repair factor IIH (TFIIH) core, which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH has CTD kinase and DNA-dependent ATPase activity, and is essential for polymerase II transcription in vitro.<ref>PMID:7961739</ref> <ref>PMID:8631896</ref>  [[https://www.uniprot.org/uniprot/KLF1_HUMAN KLF1_HUMAN]] Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation (By similarity).<ref>PMID:21055716</ref> <ref>PMID:20676099</ref>
+[https://www.uniprot.org/uniprot/TFB1_YEAST TFB1_YEAST] Acts as component of the general transcription and DNA repair factor IIH (TFIIH) core, which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH has CTD kinase and DNA-dependent ATPase activity, and is essential for polymerase II transcription in vitro.<ref>PMID:7961739</ref> <ref>PMID:8631896</ref>
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Baker's yeast]]
+[[Category: Homo sapiens]]
-[[Category: Human]]
 [[Category: Large Structures]]
-[[Category: Lafrance-Vanasse, J]]
+[[Category: Saccharomyces cerevisiae S288C]]
-[[Category: Lello, P Di]]
+[[Category: Di Lello P]]
-[[Category: Mas, C]]
+[[Category: Lafrance-Vanasse J]]
-[[Category: Omichinski, J G]]
+[[Category: Mas C]]
-[[Category: Activator]]
+[[Category: Omichinski JG]]
-[[Category: Erythroid kruppel-like factor eklf]]
-[[Category: Gene expression regulation]]
-[[Category: Mutation]]
-[[Category: Protein structure]]
-[[Category: Transcription]]
-[[Category: Transcription factor tfiih]]

2l2i

From Proteopedia

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NMR Structure of the complex between the Tfb1 subunit of TFIIH and the activation domain of EKLF

Structural highlights

Function

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