2l35

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==Structure of the DAP12-NKG2C transmembrane heterotrimer==
==Structure of the DAP12-NKG2C transmembrane heterotrimer==
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<StructureSection load='2l35' size='340' side='right'caption='[[2l35]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''>
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<StructureSection load='2l35' size='340' side='right'caption='[[2l35]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2l35]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L35 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L35 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2l35]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L35 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L35 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2l34|2l34]], [[2hac|2hac]], [[2k4f|2k4f]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 15 models</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TYROBP, DAP12, KARAP ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l35 OCA], [https://pdbe.org/2l35 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l35 RCSB], [https://www.ebi.ac.uk/pdbsum/2l35 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l35 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l35 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l35 OCA], [https://pdbe.org/2l35 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l35 RCSB], [https://www.ebi.ac.uk/pdbsum/2l35 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l35 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
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[[https://www.uniprot.org/uniprot/TYOBP_HUMAN TYOBP_HUMAN]] Nasu-Hakola disease. The disease is caused by mutations affecting the gene represented in this entry.
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[https://www.uniprot.org/uniprot/TYOBP_HUMAN TYOBP_HUMAN] Nasu-Hakola disease. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/TYOBP_HUMAN TYOBP_HUMAN]] Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin.
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[https://www.uniprot.org/uniprot/TYOBP_HUMAN TYOBP_HUMAN] Non-covalently associates with activating receptors of the CD300 family. Cross-linking of CD300-TYROBP complexes results in cellular activation. Involved for instance in neutrophil activation mediated by integrin.[https://www.uniprot.org/uniprot/NKG2C_HUMAN NKG2C_HUMAN] Immune activating receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib HLA-E loaded with signal sequence-derived peptides from non-classical MHC class Ib HLA-G molecules, likely playing a role in the generation and effector functions of adaptive natural killer (NK) cells and in maternal-fetal tolerance during pregnancy (PubMed:30134159, PubMed:37264229, PubMed:9754572). Regulates the effector functions of terminally differentiated cytotoxic lymphocyte subsets, and in particular may play a role in adaptive NK cell response to viral infection (PubMed:20952657, PubMed:21825173). Upon HLA-E-peptide binding, transmits intracellular signals via the adapter protein TYROBP/DAP12, triggering the phosphorylation of proximal signaling molecules and cell activation (PubMed:15940674, PubMed:9655483).<ref>PMID:15940674</ref> <ref>PMID:20952657</ref> <ref>PMID:21825173</ref> <ref>PMID:30134159</ref> <ref>PMID:37264229</ref> <ref>PMID:9655483</ref> <ref>PMID:9754572</ref>
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Call, M E]]
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[[Category: Call ME]]
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[[Category: Chou, J J]]
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[[Category: Chou JJ]]
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[[Category: Wucherpfennig, K W]]
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[[Category: Wucherpfennig KW]]
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[[Category: Dap12-nkg2c complex]]
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[[Category: Immunoreceptor]]
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[[Category: Protein binding]]
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[[Category: Transmembrane assembly]]
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Current revision

Structure of the DAP12-NKG2C transmembrane heterotrimer

PDB ID 2l35

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