2l3l

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==The solution structure of the N-terminal domain of human Tubulin Binding Cofactor C reveals a platform for the interaction with ab-tubulin==
==The solution structure of the N-terminal domain of human Tubulin Binding Cofactor C reveals a platform for the interaction with ab-tubulin==
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<StructureSection load='2l3l' size='340' side='right'caption='[[2l3l]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2l3l' size='340' side='right'caption='[[2l3l]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2l3l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L3L FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2l3l]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L3L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L3L FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TBCC ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l3l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l3l OCA], [https://pdbe.org/2l3l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l3l RCSB], [https://www.ebi.ac.uk/pdbsum/2l3l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l3l ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l3l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l3l OCA], [https://pdbe.org/2l3l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l3l RCSB], [https://www.ebi.ac.uk/pdbsum/2l3l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l3l ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/TBCC_HUMAN TBCC_HUMAN]] Tubulin-folding protein; involved in the final step of the tubulin folding pathway.<ref>PMID:11847227</ref>
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[https://www.uniprot.org/uniprot/TBCC_HUMAN TBCC_HUMAN] Tubulin-folding protein; involved in the final step of the tubulin folding pathway.<ref>PMID:11847227</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Human Tubulin Binding Cofactor C (hTBCC) is a 346 amino acid protein composed of two domains, which is involved in the folding pathway of newly synthesized alpha and beta-tubulins. The 3D structure of the 111-residue hTBCC N-terminal domain of the protein has not yet been determined. As a previous step to that end, here we report the NMR (1)H, (15)N, and (13)C chemical shift assignments at pH 6.0 and 25 degrees C, based on a uniformly doubly labelled (13)C/(15)N sample of the domain.
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1H, 13C, and 15N resonance assignments of the N-terminal domain of human Tubulin Binding Cofactor C.,Garcia-Mayoral MF, Castano R, Zabala JC, Santoro J, Rico M, Bruix M Biomol NMR Assign. 2010 Oct;4(2):219-21. Epub 2010 Jul 9. PMID:20617401<ref>PMID:20617401</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2l3l" style="background-color:#fffaf0;"></div>
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== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bruix, M]]
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[[Category: Bruix M]]
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[[Category: Castano, R]]
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[[Category: Castano R]]
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[[Category: Garcia-Mayoral, M F]]
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[[Category: Garcia-Mayoral MF]]
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[[Category: Lopez-Fanarraga, M L]]
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[[Category: Lopez-Fanarraga ML]]
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[[Category: Rico, M]]
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[[Category: Rico M]]
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[[Category: Zabala, J C]]
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[[Category: Zabala JC]]
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[[Category: Chaperone]]
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[[Category: Tubulin binding cofactor]]
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Current revision

The solution structure of the N-terminal domain of human Tubulin Binding Cofactor C reveals a platform for the interaction with ab-tubulin

PDB ID 2l3l

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