2l4m
From Proteopedia
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==Solution structure of the Zbeta domain of human DAI and its binding modes to B- and Z-DNA== | ==Solution structure of the Zbeta domain of human DAI and its binding modes to B- and Z-DNA== | ||
| - | <StructureSection load='2l4m' size='340' side='right'caption='[[2l4m | + | <StructureSection load='2l4m' size='340' side='right'caption='[[2l4m]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2l4m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2l4m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L4M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L4M FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l4m OCA], [https://pdbe.org/2l4m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l4m RCSB], [https://www.ebi.ac.uk/pdbsum/2l4m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l4m ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l4m OCA], [https://pdbe.org/2l4m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l4m RCSB], [https://www.ebi.ac.uk/pdbsum/2l4m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l4m ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ZBP1_HUMAN ZBP1_HUMAN] Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3 (By similarity). | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Jeon | + | [[Category: Jeon YH]] |
| - | [[Category: Khayrutdinov | + | [[Category: Khayrutdinov BI]] |
| - | [[Category: Kim | + | [[Category: Kim K]] |
| - | [[Category: Kim | + | [[Category: Kim KK]] |
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Current revision
Solution structure of the Zbeta domain of human DAI and its binding modes to B- and Z-DNA
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