2l68

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==Solution Structure of Human Holo L-FABP==
==Solution Structure of Human Holo L-FABP==
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<StructureSection load='2l68' size='340' side='right'caption='[[2l68]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2l68' size='340' side='right'caption='[[2l68]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2l68]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L68 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2l68]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L68 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1lfo|1lfo]], [[2ju3|2ju3]], [[2ju7|2ju7]], [[2f73|2f73]], [[2py1|2py1]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">FABP1, FABPL ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l68 OCA], [https://pdbe.org/2l68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l68 RCSB], [https://www.ebi.ac.uk/pdbsum/2l68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l68 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l68 OCA], [https://pdbe.org/2l68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l68 RCSB], [https://www.ebi.ac.uk/pdbsum/2l68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l68 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/FABPL_HUMAN FABPL_HUMAN]] Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.
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[https://www.uniprot.org/uniprot/FABPL_HUMAN FABPL_HUMAN] Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Liver fatty acid binding protein (L-FABP), a cytosolic protein most abundant in liver, is associated with intracellular transport of fatty acids, nuclear signaling, and regulation of intracellular lipolysis. Among the members of the intracellular lipid binding protein family, L-FABP is of particular interest as it can i), bind two fatty acid molecules simultaneously and ii), accommodate a variety of bulkier physiological ligands such as bilirubin and fatty acyl CoA. To better understand the promiscuous binding and transport properties of L-FABP, we investigated structure and dynamics of human L-FABP with and without bound ligands by means of heteronuclear NMR. The overall conformation of human L-FABP shows the typical beta-clam motif. Binding of two oleic acid (OA) molecules does not alter the protein conformation substantially, but perturbs the chemical shift of certain backbone and side-chain protons that are involved in OA binding according to the structure of the human L-FABP/OA complex. Comparison of the human apo and holo L-FABP structures revealed no evidence for an "open-cap" conformation or a "swivel-back" mechanism of the K90 side chain upon ligand binding, as proposed for rat L-FABP. Instead, we postulate that the lipid binding process in L-FABP is associated with backbone dynamics.
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Solution structure and backbone dynamics of human liver fatty acid binding protein: fatty acid binding revisited.,Cai J, Lucke C, Chen Z, Qiao Y, Klimtchuk E, Hamilton JA Biophys J. 2012 Jun 6;102(11):2585-94. doi: 10.1016/j.bpj.2012.04.039. Epub 2012 , Jun 5. PMID:22713574<ref>PMID:22713574</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2l68" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
*[[Fatty acid-binding protein 3D structures|Fatty acid-binding protein 3D structures]]
*[[Fatty acid-binding protein 3D structures|Fatty acid-binding protein 3D structures]]
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== References ==
 
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<references/>
 
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Cai, J]]
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[[Category: Cai J]]
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[[Category: Chen, Z]]
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[[Category: Chen Z]]
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[[Category: Hamilton, J A]]
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[[Category: Hamilton JA]]
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[[Category: Klimtchuk, E S]]
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[[Category: Klimtchuk ES]]
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[[Category: Luecke, C]]
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[[Category: Luecke C]]
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[[Category: Qiao, Y]]
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[[Category: Qiao Y]]
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[[Category: Fatty acid carrier]]
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[[Category: Holo form]]
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[[Category: Lipid binding protein]]
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Current revision

Solution Structure of Human Holo L-FABP

PDB ID 2l68

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