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1u9q

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Current revision (06:40, 23 August 2023) (edit) (undo)
 
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<StructureSection load='1u9q' size='340' side='right'caption='[[1u9q]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='1u9q' size='340' side='right'caption='[[1u9q]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1u9q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trycr Trycr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U9Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U9Q FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1u9q]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1U9Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1U9Q FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=186:[1-(1-METHYL-4,5-DIOXO-PENT-2-ENYLCARBAMOYL)-2-PHENYL-ETHYL]-CARBAMIC+ACID+BENZYL+ESTER'>186</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1f2a|1f2a]], [[1f29|1f29]], [[1f2b|1f2b]], [[1f2c|1f2c]], [[1me3|1me3]], [[1me4|1me4]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=186:[1-(1-METHYL-4,5-DIOXO-PENT-2-ENYLCARBAMOYL)-2-PHENYL-ETHYL]-CARBAMIC+ACID+BENZYL+ESTER'>186</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Cruzipain Cruzipain], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.51 3.4.22.51] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u9q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u9q OCA], [https://pdbe.org/1u9q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u9q RCSB], [https://www.ebi.ac.uk/pdbsum/1u9q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u9q ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1u9q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1u9q OCA], [https://pdbe.org/1u9q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1u9q RCSB], [https://www.ebi.ac.uk/pdbsum/1u9q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1u9q ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/CYSP_TRYCR CYSP_TRYCR]] Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group. The cysteine protease may play an important role in the development and differentiation of the parasites at several stages of their life cycle.
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[https://www.uniprot.org/uniprot/CYSP_TRYCR CYSP_TRYCR] Hydrolyzes chromogenic peptides at the carboxyl Arg or Lys; requires at least one more amino acid, preferably Arg, Phe, Val or Leu, between the terminal Arg or Lys and the amino-blocking group. The cysteine protease may play an important role in the development and differentiation of the parasites at several stages of their life cycle.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cruzipain]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Trycr]]
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[[Category: Trypanosoma cruzi]]
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[[Category: Baldino, C M]]
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[[Category: Baldino CM]]
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[[Category: Brinen, L S]]
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[[Category: Brinen LS]]
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[[Category: Cheng, H]]
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[[Category: Cheng H]]
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[[Category: Choe, Y]]
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[[Category: Choe Y]]
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[[Category: Craik, C S]]
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[[Category: Craik CS]]
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[[Category: Culliane, M]]
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[[Category: Culliane M]]
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[[Category: Engel, J C]]
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[[Category: Engel JC]]
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[[Category: Fiorey, M M]]
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[[Category: Fiorey MM]]
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[[Category: Grisostomi, C]]
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[[Category: Grisostomi C]]
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[[Category: Hardy, L W]]
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[[Category: Hardy LW]]
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[[Category: Hartstough, D S]]
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[[Category: Hartstough DS]]
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[[Category: Lange, M]]
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[[Category: Lange M]]
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[[Category: Pallai, P V]]
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[[Category: Pallai PV]]
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[[Category: Price, M S]]
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[[Category: Price MS]]
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[[Category: Tilton, R F]]
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[[Category: Tilton RF]]
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[[Category: Weston, S G]]
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[[Category: Weston SG]]
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[[Category: Clan-ca cysteine protease]]
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[[Category: Covalent inhibitor]]
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[[Category: Hydrolase]]
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Current revision

Crystal structure of cruzain bound to an alpha-ketoester

PDB ID 1u9q

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