7m7a
From Proteopedia
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==Legionella pneumophila MavQ lipid kinase== | ==Legionella pneumophila MavQ lipid kinase== | ||
| - | <StructureSection load='7m7a' size='340' side='right'caption='[[7m7a]]' scene=''> | + | <StructureSection load='7m7a' size='340' side='right'caption='[[7m7a]], [[Resolution|resolution]] 3.20Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7M7A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7M7A FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7m7a]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Legionella_pneumophila Legionella pneumophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7M7A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7M7A FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7m7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7m7a OCA], [https://pdbe.org/7m7a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7m7a RCSB], [https://www.ebi.ac.uk/pdbsum/7m7a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7m7a ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7m7a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7m7a OCA], [https://pdbe.org/7m7a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7m7a RCSB], [https://www.ebi.ac.uk/pdbsum/7m7a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7m7a ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q5ZRA8_LEGPH Q5ZRA8_LEGPH] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | During infection Legionella bacteria translocate a variety of effectors into host cells that modify host cell membrane trafficking for the benefit of the intracellular pathogen. Here we found a self-organizing system consisting of a bacterial phosphoinositide kinase and its opposing phosphatase that formed spatiotemporal patterns, including traveling waves, to remodel host cellular membranes. The Legionella effector MavQ, a phosphatidylinositol (PI) 3-kinase, was targeted to the endoplasmic reticulum (ER). MavQ and the Legionella PI 3-phosphatase SidP, even in the absence of other bacterial components, drove rapid PI 3-phosphate turnover on the ER, spontaneously forming traveling waves that spread along ER subdomains inducing vesicle/tubule budding. Thus, bacteria can exploit a self-organizing membrane-targeting mechanism to hijack host cellular structures for survival. | ||
| + | |||
| + | Dynamic remodeling of host membranes by self-organizing bacterial effectors.,Hsieh TS, Lopez VA, Black MH, Osinski A, Pawlowski K, Tomchick DR, Liou J, Tagliabracci VS Science. 2021 Apr 29. pii: science.aay8118. doi: 10.1126/science.aay8118. PMID:33927055<ref>PMID:33927055</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7m7a" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| + | [[Category: Legionella pneumophila]] | ||
[[Category: Hsieh TS]] | [[Category: Hsieh TS]] | ||
[[Category: Lopez VA]] | [[Category: Lopez VA]] | ||
[[Category: Tagliabracci VS]] | [[Category: Tagliabracci VS]] | ||
[[Category: Tomchick DR]] | [[Category: Tomchick DR]] | ||
Current revision
Legionella pneumophila MavQ lipid kinase
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