6thi

<StructureSection load='6thi' size='340' side='right'caption='[[6thi]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>

<table><tr><td colspan='2'>[[6thi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Buthus_eupeus Buthus eupeus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6THI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6THI FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6thi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6thi OCA], [https://pdbe.org/6thi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6thi RCSB], [https://www.ebi.ac.uk/pdbsum/6thi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6thi ProSAT]</span></td></tr>

== Function ==

[[https://www.uniprot.org/uniprot/SCXN1_MESEU SCXN1_MESEU]] Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This toxin inhibits inactivation of Nav1.6/SCN8A (EC(50)=3.1 uM) and drosophila DmNav1 (EC(50)=1.17 uM) (PubMed:21969612, Ref.2). The toxin (1 uM) does not significantly shift the midpoint of activation at the two channels, but induces a significant depolarizing shift in the V(1/2) of inactivation of the channels (PubMed:21969612).<ref>PMID:21969612</ref> [PROSITE-ProRule:PRU01210]

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== Publication Abstract from PubMed ==

Old world scorpions produce an abundance of toxins called alpha-NaTx, which interfere with the fast inactivation of voltage-gated sodium channels. Their selectivity to channels of mammals or insects depends on a part of toxin named the specificity module. We report here the spatial structure of a major and broadly active toxin MeuNaTxalpha-1 from the venom of Mesobuthus eupeus. Notably, its specificity module is markedly different from other alpha-NaTx with known 3D structure. Close inspection shows that its conformation is a result of an interplay between protein motifs such as the nest and niche, which eventually shape alpha-NaTx structural diversity.

Structure of MeuNaTxalpha-1 toxin from scorpion venom highlights the importance of the nest motif.,Mineev KS, Kuzmenkov AI, Arseniev AS, Vassilevski AA Proteins. 2021 Mar 13. doi: 10.1002/prot.26074. PMID:33713480<ref>PMID:33713480</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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== References ==

<references/>

[[Category: Buthus eupeus]]

[[Category: Arseniev, A S]]

[[Category: Khusainov, G A]]

[[Category: Kuzmenkov, A I]]

[[Category: Mineev, K S]]

[[Category: Vassilevski, A A]]

[[Category: Toxin]]