1coo

<StructureSection load='1coo' size='340' side='right'caption='[[1coo]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>

<table><tr><td colspan='2'>[[1coo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ecoli Ecoli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1COO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1COO FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1coo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1coo OCA], [https://pdbe.org/1coo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1coo RCSB], [https://www.ebi.ac.uk/pdbsum/1coo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1coo ProSAT]</span></td></tr>

[[https://www.uniprot.org/uniprot/RPOA_ECOLI RPOA_ECOLI]] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit plays an important role in subunit assembly since its dimerization is the first step in the sequential assembly of subunits to form the holoenzyme.[HAMAP-Rule:MF_00059]

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== Publication Abstract from PubMed ==

The structure of the carboxyl-terminal domain of the Escherichia coli RNA polymerase alpha subunit (alpha CTD), which is regarded as the contact site for transcription activator proteins and for the promoter UP element, was determined by nuclear magnetic resonance spectroscopy. Its compact structure of four helices and two long arms enclosing its hydrophobic core shows a folding topology distinct from those of other DNA-binding proteins. The UP element binding site was found on the surface comprising helix 1, the amino-terminal end of helix 4, and the preceding loop. Mutation experiments indicated that the contact sites for transcription activator proteins are also on the same surface.

Solution structure of the activator contact domain of the RNA polymerase alpha subunit.,Jeon YH, Negishi T, Shirakawa M, Yamazaki T, Fujita N, Ishihama A, Kyogoku Y Science. 1995 Dec 1;270(5241):1495-7. PMID:7491496<ref>PMID:7491496</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 1coo" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Ecoli]]

[[Category: Fujita, N]]

[[Category: Ishihama, A]]

[[Category: Jeon, Y H]]

[[Category: Kyogoku, Y]]

[[Category: Negishi, T]]

[[Category: Shirakawa, M]]

[[Category: Yamazaki, T]]

[[Category: Transcription regulation]]