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1m8t

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Current revision (07:18, 25 October 2023) (edit) (undo)
 
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<StructureSection load='1m8t' size='340' side='right'caption='[[1m8t]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='1m8t' size='340' side='right'caption='[[1m8t]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1m8t]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/King_cobra King cobra]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M8T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M8T FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1m8t]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Ophiophagus_hannah Ophiophagus hannah]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1M8T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1M8T FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HEZ:HEXANE-1,6-DIOL'>HEZ</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HEZ:HEXANE-1,6-DIOL'>HEZ</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m8t OCA], [https://pdbe.org/1m8t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m8t RCSB], [https://www.ebi.ac.uk/pdbsum/1m8t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m8t ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1m8t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1m8t OCA], [https://pdbe.org/1m8t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1m8t RCSB], [https://www.ebi.ac.uk/pdbsum/1m8t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1m8t ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PA2A2_OPHHA PA2A2_OPHHA]] Snake venom phospholipase A2 (PLA2) that displays edema-inducing and moderate anticoagulant activities. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
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[https://www.uniprot.org/uniprot/PA2A2_OPHHA PA2A2_OPHHA] Snake venom phospholipase A2 (PLA2) that displays edema-inducing and moderate anticoagulant activities. PLA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: King cobra]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Gu, L]]
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[[Category: Ophiophagus hannah]]
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[[Category: Lin, Z]]
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[[Category: Gu L]]
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[[Category: Shu, Y]]
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[[Category: Lin Z]]
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[[Category: Wang, Q]]
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[[Category: Shu Y]]
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[[Category: Xu, S]]
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[[Category: Wang Q]]
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[[Category: Alpha]]
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[[Category: Xu S]]
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[[Category: Beta]]
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[[Category: Hydrolase]]
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[[Category: Phospholipase a2 structure]]
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[[Category: Twinned crystal]]
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Current revision

Structure of an acidic Phospholipase A2 from the venom of Ophiophagus hannah at 2.1 resolution from a hemihedrally twinned crystal form

PDB ID 1m8t

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OCA

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