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7ep7

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'''Unreleased structure'''
 
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The entry 7ep7 is ON HOLD
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==The complex structure of Gpsm2 and Whirlin==
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<StructureSection load='7ep7' size='340' side='right'caption='[[7ep7]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7ep7]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EP7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EP7 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ep7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ep7 OCA], [https://pdbe.org/7ep7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ep7 RCSB], [https://www.ebi.ac.uk/pdbsum/7ep7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ep7 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GPSM2_MOUSE GPSM2_MOUSE] Plays an important role in spindle pole orientation (By similarity). Interacts and contributes to the functional activity of G(i) alpha proteins. Acts to stabilize the apical complex during neuroblast divisions.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The mechanosensory stereocilia in hair cells are organized into rows of graded height, a property crucial for auditory perception. Gpsm2-Galphai-Whirlin-Myo15-Eps8 complex at tips of the tallest stereocilia is proposed to define hair bundle row identity, although the underlying mechanism remains elusive. Here, we find that Gpsm2 could undergo phase separation. Moreover, row 1-specific Gpsm2-Galphai complex significantly promotes the formation of the five-component tip complex density (5xTCD) condensates. The 5xTCD condensates display much stronger actin-bundling ability than those without Gpsm2-Galphai, which may provide critical insights into how Gpsm2-Galphai specifies the tallest stereocilia. A deafness-associated mutation of Gpsm2 leads to impaired formation of the 5xTCD condensates and consequently reduced actin bundling, providing possible clues for etiology of hearing loss in patients with Chudley-McCullough syndrome.
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Authors:
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Promotion of row 1-specific tip complex condensates by Gpsm2-Galphai provides insights into row identity of the tallest stereocilia.,Shi Y, Lin L, Wang C, Zhu J Sci Adv. 2022 Jun 10;8(23):eabn4556. doi: 10.1126/sciadv.abn4556. Epub 2022 Jun, 10. PMID:35687681<ref>PMID:35687681</ref>
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Description:
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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<div class="pdbe-citations 7ep7" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Lin L]]
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[[Category: Shi Y]]
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[[Category: Wang C]]
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[[Category: Zhu J]]

Current revision

The complex structure of Gpsm2 and Whirlin

PDB ID 7ep7

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OCA

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