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7ocl

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(New page: '''Unreleased structure''' The entry 7ocl is ON HOLD Authors: de Jonge, H., de Nola, G., Gherardi, E. Description: K1K1, a potent recombinant minimal hepatocyte growth factor/scatter f...)
Current revision (07:50, 1 May 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 7ocl is ON HOLD
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==K1K1, a potent recombinant minimal hepatocyte growth factor/scatter factor mimic==
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<StructureSection load='7ocl' size='340' side='right'caption='[[7ocl]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7ocl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OCL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OCL FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ocl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ocl OCA], [https://pdbe.org/7ocl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ocl RCSB], [https://www.ebi.ac.uk/pdbsum/7ocl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ocl ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/HGF_HUMAN HGF_HUMAN] Defects in HGF are the cause of deafness autosomal recessive type 39 (DFNB39) [MIM:[https://omim.org/entry/608265 608265]. A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.<ref>PMID:19576567</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/HGF_HUMAN HGF_HUMAN] Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.<ref>PMID:15167892</ref> <ref>PMID:20624990</ref>
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Authors: de Jonge, H., de Nola, G., Gherardi, E.
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==See Also==
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*[[Hepatocyte growth factor receptor 3D structures|Hepatocyte growth factor receptor 3D structures]]
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Description: K1K1, a potent recombinant minimal hepatocyte growth factor/scatter factor mimic
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Gherardi, E]]
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__TOC__
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[[Category: De Jonge, H]]
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</StructureSection>
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[[Category: De Nola, G]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Gherardi E]]
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[[Category: De Jonge H]]
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[[Category: De Nola G]]

Current revision

K1K1, a potent recombinant minimal hepatocyte growth factor/scatter factor mimic

PDB ID 7ocl

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