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5ow8

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Current revision (01:26, 28 December 2023) (edit) (undo)
 
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<StructureSection load='5ow8' size='340' side='right'caption='[[5ow8]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='5ow8' size='340' side='right'caption='[[5ow8]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ow8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OW8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5OW8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ow8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OW8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5OW8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AYN:1-[3-(trifluoromethyl)phenyl]indole-2-carboxamide'>AYN</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PLA2G10 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AYN:1-[3-(trifluoromethyl)phenyl]indole-2-carboxamide'>AYN</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ow8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ow8 OCA], [https://pdbe.org/5ow8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ow8 RCSB], [https://www.ebi.ac.uk/pdbsum/5ow8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ow8 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ow8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ow8 OCA], [https://pdbe.org/5ow8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ow8 RCSB], [https://www.ebi.ac.uk/pdbsum/5ow8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ow8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PA2GX_HUMAN PA2GX_HUMAN]] PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine.
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[https://www.uniprot.org/uniprot/PA2GX_HUMAN PA2GX_HUMAN] PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bodin, C]]
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[[Category: Bodin C]]
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[[Category: Knerr, L]]
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[[Category: Knerr L]]
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[[Category: Pettersen, D]]
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[[Category: Pettersen D]]
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[[Category: Roth, R G]]
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[[Category: Roth RG]]
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[[Category: Sandmark, J S]]
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[[Category: Sandmark JS]]
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[[Category: Inhibitor]]
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[[Category: Lipid binding protein]]
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[[Category: Phospholipase]]
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[[Category: Secreted]]
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Current revision

Indole-2 carboxamides as selective secreted phospholipase A2 type X (sPLA2-X) inhibitors

PDB ID 5ow8

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