1mvg

From Proteopedia

(Difference between revisions)

Current revision

NMR solution structure of chicken Liver basic Fatty Acid Binding Protein (Lb-FABP)

Structural highlights

1mvg is a 1 chain structure with sequence from Gallus gallus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

FABPL_CHICK Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport. Binds 2 molecules of cholate per subunit.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Chicken liver basic fatty acid binding protein (Lb-FABP) belongs to the basic-type fatty acid binding proteins, a novel group of proteins isolated from liver of different non mammalian species whose structure is not known. The structure of Lb-FABP has been solved by (1)H NMR. The overall fold of Lb-FABP, common to the other proteins of the family, consists of ten antiparallel beta-strands organised in two nearly ortogonal beta-sheets with two alpha helices closing the protein cavity where small hydrophobic ligands can be bound. The binding specificity of the protein is not known, however, based on the high sequence and structural similarity with an orthologous protein, ileal lipid binding protein, it is suggested that bile acids may be the putative ligands.

Solution structure of chicken liver basic fatty acid binding protein.,Vasile F, Ragona L, Catalano M, Zetta L, Perduca M, Monaco H, Molinari H J Biomol NMR. 2003 Feb;25(2):157-60. PMID:12652125^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Vasile F, Ragona L, Catalano M, Zetta L, Perduca M, Monaco H, Molinari H. Solution structure of chicken liver basic fatty acid binding protein. J Biomol NMR. 2003 Feb;25(2):157-60. PMID:12652125

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1mvg"

@@ Line 1: / Line 1: @@
 ==NMR solution structure of chicken Liver basic Fatty Acid Binding Protein (Lb-FABP)==
-<StructureSection load='1mvg' size='340' side='right'caption='[[1mvg]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
+<StructureSection load='1mvg' size='340' side='right'caption='[[1mvg]]' scene=''>
 == Structural highlights ==
 <table><tr><td colspan='2'>[[1mvg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MVG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MVG FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mvg OCA], [https://pdbe.org/1mvg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mvg RCSB], [https://www.ebi.ac.uk/pdbsum/1mvg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mvg ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1mvg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mvg OCA], [https://pdbe.org/1mvg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1mvg RCSB], [https://www.ebi.ac.uk/pdbsum/1mvg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1mvg ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/FABPL_CHICK FABPL_CHICK]] Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport. Binds 2 molecules of cholate per subunit.
+[https://www.uniprot.org/uniprot/FABPL_CHICK FABPL_CHICK] Binds free fatty acids and their coenzyme A derivatives, bilirubin, and some other small molecules in the cytoplasm. May be involved in intracellular lipid transport. Binds 2 molecules of cholate per subunit.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 36: / Line 37: @@
 [[Category: Gallus gallus]]
 [[Category: Large Structures]]
-[[Category: Catalano, M]]
+[[Category: Catalano M]]
-[[Category: Molinari, H]]
+[[Category: Molinari H]]
-[[Category: Monaco, H]]
+[[Category: Monaco H]]
-[[Category: Perduca, M]]
+[[Category: Perduca M]]
-[[Category: Ragona, L]]
+[[Category: Ragona L]]
-[[Category: Vasile, F]]
+[[Category: Vasile F]]
-[[Category: Zetta, L]]
+[[Category: Zetta L]]
-[[Category: Beta-barrel]]
-[[Category: Calycin]]
-[[Category: Fatty acid binding protein]]
-[[Category: Helix-turn-helix motif]]
-[[Category: Ten antiparallel beta strand]]
-[[Category: Transport protein]]

1mvg

From Proteopedia

Current revision

NMR solution structure of chicken Liver basic Fatty Acid Binding Protein (Lb-FABP)

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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