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2c0y

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Current revision (14:01, 13 December 2023) (edit) (undo)
 
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<StructureSection load='2c0y' size='340' side='right'caption='[[2c0y]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='2c0y' size='340' side='right'caption='[[2c0y]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2c0y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C0Y FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2c0y]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C0Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C0Y FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1bxf|1bxf]], [[1glo|1glo]], [[1ms6|1ms6]], [[1npz|1npz]], [[1nqc|1nqc]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c0y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c0y OCA], [https://pdbe.org/2c0y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c0y RCSB], [https://www.ebi.ac.uk/pdbsum/2c0y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c0y ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c0y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c0y OCA], [https://pdbe.org/2c0y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c0y RCSB], [https://www.ebi.ac.uk/pdbsum/2c0y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c0y ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/CATS_HUMAN CATS_HUMAN]] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.
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[https://www.uniprot.org/uniprot/CATS_HUMAN CATS_HUMAN] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cathepsin S]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Hilgenfeld, R]]
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[[Category: Hilgenfeld R]]
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[[Category: Kaulmann, G]]
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[[Category: Kaulmann G]]
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[[Category: Palm, G J]]
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[[Category: Palm GJ]]
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[[Category: Schilling, K]]
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[[Category: Schilling K]]
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[[Category: Wiederanders, B]]
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[[Category: Wiederanders B]]
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[[Category: Glycoprotein]]
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[[Category: Hydrolase]]
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[[Category: Lysosome]]
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[[Category: Procathepsin s]]
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[[Category: Proenzyme]]
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[[Category: Prosegment binding loop]]
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[[Category: Protease]]
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[[Category: Proteinase]]
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[[Category: Thiol protease]]
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[[Category: Zymogen]]
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Current revision

THE CRYSTAL STRUCTURE OF A CYS25ALA MUTANT OF HUMAN PROCATHEPSIN S

PDB ID 2c0y

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