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Beta-lactamase 3D structures
From Proteopedia
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**[[3dtm]], [[1bza]], [[1ck3]], [[1esu]], [[1jwp]], [[1lhy]], [[1li0]], [[1m40]], [[1zg6]], [[2v1z]], [[2v20]], [[3cmz]], [[3jyi]], [[4ibr]], [[4ibx]], [[4mez]], [[4rx2]], [[4rx3]], [[6b2n]], [[5kpu]], [[5iq8]], [[5i63]], [[5i52]], [[5hw5]], [[5hw1]], [[5hvi]], [[6ayk]], [[6apa]] - EcBlac A Tem-1 (mutant) - ''Escherichia coli''<br /> | **[[3dtm]], [[1bza]], [[1ck3]], [[1esu]], [[1jwp]], [[1lhy]], [[1li0]], [[1m40]], [[1zg6]], [[2v1z]], [[2v20]], [[3cmz]], [[3jyi]], [[4ibr]], [[4ibx]], [[4mez]], [[4rx2]], [[4rx3]], [[6b2n]], [[5kpu]], [[5iq8]], [[5i63]], [[5i52]], [[5hw5]], [[5hw1]], [[5hvi]], [[6ayk]], [[6apa]] - EcBlac A Tem-1 (mutant) - ''Escherichia coli''<br /> | ||
| - | **[[1btl]], [[1iys]], [[1xpb]], [[1zg4]], [[4gku]], [[4rva]], [[5npo]] - EcBlac A Tem-1<br /> | + | **[[1btl]], [[1iys]], [[1xpb]], [[1zg4]], [[4gku]], [[4rva]], [[5npo]], [[7u6q]] - EcBlac A Tem-1<br /> |
**[[4r4s]], [[4r4r]], [[4qy6]], [[4qy5]] - EcBlac A Tem-1/PSE-4<br /> | **[[4r4s]], [[4r4r]], [[4qy6]], [[4qy5]] - EcBlac A Tem-1/PSE-4<br /> | ||
**[[1lhy]] - EcBlac A Tem-30 (mutant) <br /> | **[[1lhy]] - EcBlac A Tem-30 (mutant) <br /> | ||
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**[[1yt4]] - EcBlac A Tem-76 (mutant) <br /> | **[[1yt4]] - EcBlac A Tem-76 (mutant) <br /> | ||
**[[3toi]] - EcBlac A Tem-116 (mutant)<br /> | **[[3toi]] - EcBlac A Tem-116 (mutant)<br /> | ||
| + | **[[7qor]] – EcBlac Tem-171 <br /> | ||
**[[5chu]], [[5cgs]] – EcBlac FOX-4<br /> | **[[5chu]], [[5cgs]] – EcBlac FOX-4<br /> | ||
**[[5cgw]] – EcBlac FOX-4 (mutant)<br /> | **[[5cgw]] – EcBlac FOX-4 (mutant)<br /> | ||
**[[4zj2]], [[4zj1]] – EcBlac Tem (mutant) <br /> | **[[4zj2]], [[4zj1]] – EcBlac Tem (mutant) <br /> | ||
**[[4id4]] – EcBlac/PaBlac Tem<br /> | **[[4id4]] – EcBlac/PaBlac Tem<br /> | ||
| - | **[[3o3v]] – EcBlac peptidase domain<br /> | ||
**[[1o7e]], [[1n4o]], [[5ne2]] – StmBlac A – ''Stenotrophonas maltophilia''<br /> | **[[1o7e]], [[1n4o]], [[5ne2]] – StmBlac A – ''Stenotrophonas maltophilia''<br /> | ||
**[[1htz]] – KpBlac A Tem-52 – ''Klebsiella pneumoniae''<br /> | **[[1htz]] – KpBlac A Tem-52 – ''Klebsiella pneumoniae''<br /> | ||
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**[[5fa7]] - EcBlac A + inhibitor<br /> | **[[5fa7]] - EcBlac A + inhibitor<br /> | ||
**[[1nxy]], [[1ny0]], [[1nym]], [[1nyy]] - EcBlac A (mutant) + boronic acid inhibitor<br /> | **[[1nxy]], [[1ny0]], [[1nym]], [[1nyy]] - EcBlac A (mutant) + boronic acid inhibitor<br /> | ||
| + | **[[8de0]] - EcBlac A Tem-1 + drug<br /> | ||
| + | **[[8de1]], [[8de2]] - EcBlac A Tem-1 (mutant) + drug<br /> | ||
**[[1pzo]], [[1pzp]] - EcBlac A Tem-1 (mutant) + inhibitor<br /> | **[[1pzo]], [[1pzp]] - EcBlac A Tem-1 (mutant) + inhibitor<br /> | ||
**[[1erm]], [[1ero]], [[1erq]] – EcBlac A Tem-1 + boronic acid inhibitor<br /> | **[[1erm]], [[1ero]], [[1erq]] – EcBlac A Tem-1 + boronic acid inhibitor<br /> | ||
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**[[6afn]], [[6afp]] - BtBlac A (mutant) + boronic acid inhibitor <br /> | **[[6afn]], [[6afp]] - BtBlac A (mutant) + boronic acid inhibitor <br /> | ||
**[[5ne1]] - StmBlac A + boronic acid inhibitor <br /> | **[[5ne1]] - StmBlac A + boronic acid inhibitor <br /> | ||
| - | **[[6qw7]], [[6qw8]] - StmBlac A + inhibitor <br /> | + | **[[6qw7]], [[6qw8]], [[7bj8]] - StmBlac A + inhibitor <br /> |
**[[6w2z]] - BsBlac A + inhibitor <br /> | **[[6w2z]] - BsBlac A + inhibitor <br /> | ||
**[[6w33]] – BcBlac A (mutant) + inhibitor <br /> | **[[6w33]] – BcBlac A (mutant) + inhibitor <br /> | ||
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*β-lactamase class A binary complex with antibiotics | *β-lactamase class A binary complex with antibiotics | ||
| + | **[[7qlp]], [[7qnk]] – EcBlac Tem-171 + antibiotic<br /> | ||
**[[1tem]], [[1bt5]], [[1fqg]], [[1iyo]], [[1iyp]], [[1iyq]], [[1jvj]], [[3q07]], [[3q1f]] - EcBlac A (mutant) + antibiotic<br /> | **[[1tem]], [[1bt5]], [[1fqg]], [[1iyo]], [[1iyp]], [[1iyq]], [[1jvj]], [[3q07]], [[3q1f]] - EcBlac A (mutant) + antibiotic<br /> | ||
**[[5kmw]] - EcBlac A (mutant) + penicillin derivative<br /> | **[[5kmw]] - EcBlac A (mutant) + penicillin derivative<br /> | ||
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**[[4ua6]], [[6d7h]] – EcESBL Ctx-M-14 <br /> | **[[4ua6]], [[6d7h]] – EcESBL Ctx-M-14 <br /> | ||
**[[1ylt]], [[5vth]], [[5twd]], [[6cyn]], [[6cyk]], [[6d7i]], [[6v5e]], [[6v6g]], [[6v6p]], [[7k2x]] - EcBlac A Ctx-M-14 (mutant)<br /> | **[[1ylt]], [[5vth]], [[5twd]], [[6cyn]], [[6cyk]], [[6d7i]], [[6v5e]], [[6v6g]], [[6v6p]], [[7k2x]] - EcBlac A Ctx-M-14 (mutant)<br /> | ||
| - | **[[4hbt]] – EcESBL Ctx-M-15<br /> | + | **[[4hbt]], [[7u57]] – EcESBL Ctx-M-15<br /> |
**[[1ylw]] - EcESBL Ctx-M-16<br /> | **[[1ylw]] - EcESBL Ctx-M-16<br /> | ||
**[[1ylp]] - EcESBL Ctx-M-27 (mutant)<br /> | **[[1ylp]] - EcESBL Ctx-M-27 (mutant)<br /> | ||
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**[[4pm8]] - KpBlac A Ctx-M-14 <br /> | **[[4pm8]] - KpBlac A Ctx-M-14 <br /> | ||
**[[4pm6]], [[4pma]] - KpBlac A Ctx-M-14 (mutant) <br /> | **[[4pm6]], [[4pma]] - KpBlac A Ctx-M-14 (mutant) <br /> | ||
| + | **[[7bh3]], [[7bh4]], [[7bh5]], [[7bh6]], [[7bh7]] - KpBlac A Ctx-M-15 <br /> | ||
| + | **[[7qqc]], [[7r3q]], [[7r3r]] - KpBlac A Ctx-M-15 (mutant)<br /> | ||
**[[2qpn]] – KpESBL A Ges-1<br /> | **[[2qpn]] – KpESBL A Ges-1<br /> | ||
**[[6ts9]] - PaESBL A Ges-5<br /> | **[[6ts9]] - PaESBL A Ges-5<br /> | ||
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**[[3g2y]], [[3g2z]], [[3g30]], [[3g31]], [[3g32]], [[3g34]], [[3g35]], [[4dds]], [[4ddy]], [[4de0]], [[4de1]], [[4de2]], [[4de3]], [[1yly]], [[1ym1]], [[1yms]] - EcBlac A Ctx-M-9 + inhibitor<br /> | **[[3g2y]], [[3g2z]], [[3g30]], [[3g31]], [[3g32]], [[3g34]], [[3g35]], [[4dds]], [[4ddy]], [[4de0]], [[4de1]], [[4de2]], [[4de3]], [[1yly]], [[1ym1]], [[1yms]] - EcBlac A Ctx-M-9 + inhibitor<br /> | ||
**[[4len]] - EcESBL Ctx-M-9 (mutant) + inhibitor<br /> | **[[4len]] - EcESBL Ctx-M-9 (mutant) + inhibitor<br /> | ||
| - | **[[4uaa]], [[4ua7]], [[6md8]], [[6mia]], [[6mz1]], [[6mz2]], [[6ooe]], [[6oof]], [[6ooj]], [[6ook]] – EcESBL Ctx-M-14 + inhibitor<br /> | + | **[[4uaa]], [[4ua7]], [[6md8]], [[6mia]], [[6mz1]], [[6mz2]], [[6ooe]], [[6oof]], [[6ooj]], [[6ook]], [[7s0v]] – EcESBL Ctx-M-14 + inhibitor<br /> |
**[[6bt6]], [[6v7h]], [[6v7t]], [[6v83]], [[6v8v]] – EcESBL Ctx-M-14 (mutant) + inhibitor<br /> | **[[6bt6]], [[6v7h]], [[6v7t]], [[6v83]], [[6v8v]] – EcESBL Ctx-M-14 (mutant) + inhibitor<br /> | ||
**[[4ua9]], [[1ylz]] – EcESBL Ctx-M-14 + boronic acid inhibitor<br /> | **[[4ua9]], [[1ylz]] – EcESBL Ctx-M-14 + boronic acid inhibitor<br /> | ||
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**[[7k2w]], [[7k2y]] – EcESBL Ctx-M-14 (mutant) + antibiotic<br /> | **[[7k2w]], [[7k2y]] – EcESBL Ctx-M-14 (mutant) + antibiotic<br /> | ||
**[[4xxr]], [[5u53]], [[5tw6]], [[5twe]] - EcESBL Ctx-M-14 (mutant) + antibiotic<br /> | **[[4xxr]], [[5u53]], [[5tw6]], [[5twe]] - EcESBL Ctx-M-14 (mutant) + antibiotic<br /> | ||
| - | **[[4hbu]], [[6sp6]] – EcESBL Ctx-M-15 + inhibitor<br /> | + | **[[4hbu]], [[6sp6]], [[7u49]] – EcESBL Ctx-M-15 + inhibitor<br /> |
| - | **[[4xuz]] - KpBlac A Ctx-M-15 + boronic acid inhibitor<br /> | + | **[[4xuz]], [[7ti0]] - KpBlac A Ctx-M-15 + boronic acid inhibitor<br /> |
| + | **[[7u4b]] – EcESBL Ctx-M-15 + antibiotic<br /> | ||
**[[6bu3]] – EcESBL Ctx-M-27 + inhibitor<br /> | **[[6bu3]] – EcESBL Ctx-M-27 + inhibitor<br /> | ||
**[[4x69]] – EcESBL Ctx-M-44 + inhibitor<br /> | **[[4x69]] – EcESBL Ctx-M-44 + inhibitor<br /> | ||
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**[[6bpf]] – SeESBL Ctx-M-151 + inhibitor <br /> | **[[6bpf]] – SeESBL Ctx-M-151 + inhibitor <br /> | ||
**[[6d3g]] – CfESBL Per-2 + inhibitor <br /> | **[[6d3g]] – CfESBL Per-2 + inhibitor <br /> | ||
| + | **[[7bds]] – KpESBL Ctx-M-15 + drug <br /> | ||
| + | **[[7bdr]], [[7qq5]] – KpESBL Ctx-M-15 (mutant) + drug <br /> | ||
*Extended-spectrum β-lactamase class A binary complex with antibiotics | *Extended-spectrum β-lactamase class A binary complex with antibiotics | ||
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**[[3hlw]], [[3huo]], [[3hvf]] - EcESBL Ctx-M-9 (mutant) + antibiotic<br /> | **[[3hlw]], [[3huo]], [[3hvf]] - EcESBL Ctx-M-9 (mutant) + antibiotic<br /> | ||
**[[4xxr]], [[5u53]], [[5tw6]], [[5twe]], [[6cyu]], [[6cyq]]. [[6bt6]] - EcESBL Ctx-M-14 (mutant) + antibiotic<br /> | **[[4xxr]], [[5u53]], [[5tw6]], [[5twe]], [[6cyu]], [[6cyq]]. [[6bt6]] - EcESBL Ctx-M-14 (mutant) + antibiotic<br /> | ||
| - | **[[4pm9]] - KpBlac A Ctx-M-14 + antibiotic<br /> | + | **[[4pm9]], [[7q11]] - KpBlac A Ctx-M-14 + antibiotic<br /> |
**[[4pm5]], [[4pm7]] - KpBlac A Ctx-M-14 (mutant) + antibiotic<br /> | **[[4pm5]], [[4pm7]] - KpBlac A Ctx-M-14 (mutant) + antibiotic<br /> | ||
**[[4s2i]] - KpBlac A Ctx-M-15 + antibiotic<br /> | **[[4s2i]] - KpBlac A Ctx-M-15 + antibiotic<br /> | ||
| - | **[[5gwa]] – SmESBL Tla-3 + antibiotic<br /> | + | **[[5gwa]], [[7o0o]] – SmESBL Tla-3 + antibiotic<br /> |
*β-lactamase class A complex with β-lactamase inhibitor protein (Blip) | *β-lactamase class A complex with β-lactamase inhibitor protein (Blip) | ||
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**[[1l9y]] - FgBlac B (mutant) <br /> | **[[1l9y]] - FgBlac B (mutant) <br /> | ||
**[[5n5g]] - PaBlac B Vim-1<br /> | **[[5n5g]] - PaBlac B Vim-1<br /> | ||
| - | **[[1ko2]], [[1ko3]], [[4bz3]], [[4nq2]], [[5yd7]] – PaBlac B Vim-2 - ''Pseudomonas aeruginosa''<br /> | + | **[[1ko2]], [[1ko3]], [[4bz3]], [[4nq2]], [[5yd7]], [[7cjl]] – PaBlac B Vim-2 - ''Pseudomonas aeruginosa''<br /> |
**[[2whg]], [[2wrs]] - PaBlac B Vim-4<br /> | **[[2whg]], [[2wrs]] - PaBlac B Vim-4<br /> | ||
**[[4d1t]] - PaBlac B Vim-7<br /> | **[[4d1t]] - PaBlac B Vim-7<br /> | ||
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**[[4ax0]], [[4ax1]] - PaBlac B Aim-1 (mutant)<br /> | **[[4ax0]], [[4ax1]] - PaBlac B Aim-1 (mutant)<br /> | ||
**[[2y87]], [[2y8a]], [[2y8b]] - PaBlac B Vim-7<br /> | **[[2y87]], [[2y8a]], [[2y8b]] - PaBlac B Vim-7<br /> | ||
| - | **[[2x02]] - PaBlac Oxa-10<br /> | + | **[[2x02]], [[7b3r]], [[7b3s]], [[7b3u]] - PaBlac Oxa-10<br /> |
**[[2x01]] - PaBlac Oxa-10 (mutant)<br /> | **[[2x01]] - PaBlac Oxa-10 (mutant)<br /> | ||
**[[4uam]], [[2fhx]], [[4bp0]], [[5nde]] - PaBlac Imp-1 <br /> | **[[4uam]], [[2fhx]], [[4bp0]], [[5nde]] - PaBlac Imp-1 <br /> | ||
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**[[6r79]], [[6yi4]] - PaBlac Imp-13 <br /> | **[[6r79]], [[6yi4]] - PaBlac Imp-13 <br /> | ||
**[[5b3r]] - PaBlac Imp-18 <br /> | **[[5b3r]] - PaBlac Imp-18 <br /> | ||
| - | **[[5ev6]], [[5y5b]] - SmBlac Imp-1 – ''Serratia marcescens''<br /> | + | **[[5ev6]], [[5y5b]], [[7dtm]] - SmBlac Imp-1 – ''Serratia marcescens''<br /> |
| - | **[[1wuo]], [[1wup]] - SmBlac Imp-1 (mutant) <br /> | + | **[[1wuo]], [[1wup]], [[7dtn]] - SmBlac Imp-1 (mutant) <br /> |
**[[3vpe]] - SmBlac Smb-1<br /> | **[[3vpe]] - SmBlac Smb-1<br /> | ||
**[[5fdh]] - SmBlac Oxa-405<br /> | **[[5fdh]] - SmBlac Oxa-405<br /> | ||
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**[[3l6n]] – Blac B – ''Chryseobacter indolegenes''<br /> | **[[3l6n]] – Blac B – ''Chryseobacter indolegenes''<br /> | ||
**[[3r2u]] – SaBlac B<br /> | **[[3r2u]] – SaBlac B<br /> | ||
| - | **[[3rkj]], [[3sbl]], [[3sfp]], [[3spu]], [[3zr9]], [[3pg4]], [[6c6i]], [[3srx]], [[4h0d]], [[6c6i]], [[5xp6]], [[5n0i | + | **[[3rkj]], [[3sbl]], [[3sfp]], [[3spu]], [[3zr9]], [[3pg4]], [[6c6i]], [[3srx]], [[4h0d]], [[6c6i]], [[5xp6]], [[5n0i]], [[5k4m]], [[5jqj]], [[5xp9]], [[5zgi]], [[5nbk]], [[[6cac]], [[6ex7]], [[6lhe]], [[6twt]] - KpBlac B Ndm-1 + metal ion<br /> |
**[[5zgf]], [[7ct2]] - KpBlac B Ndm-1 (mutant) + metal ion<br /> | **[[5zgf]], [[7ct2]] - KpBlac B Ndm-1 (mutant) + metal ion<br /> | ||
**[[6mh0]] - KpBlac B Ndm-3 + Zn<br /> | **[[6mh0]] - KpBlac B Ndm-3 + Zn<br /> | ||
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**[[5wih]] - EcBlac B Ndm-12<br /> | **[[5wih]] - EcBlac B Ndm-12<br /> | ||
**[[6bm9]] – EcBlac B Vim-2<br /> | **[[6bm9]] – EcBlac B Vim-2<br /> | ||
| - | **[[ | + | **[[7xhx]] - EcBlac Imp-6 <br /> |
**[[6skp]], [[6skq]], [[6skr]] - EcBlac Oxa-10 <br /> | **[[6skp]], [[6skq]], [[6skr]] - EcBlac Oxa-10 <br /> | ||
**[[6ovz]] - EcBlac <br /> | **[[6ovz]] - EcBlac <br /> | ||
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**[[5b1u]], [[5b15]], [[5aya]], [[5axo]] - SmBlac Smb-1 + antibiotic<br /> | **[[5b1u]], [[5b15]], [[5aya]], [[5axo]] - SmBlac Smb-1 + antibiotic<br /> | ||
**[[4zej]] - PsBlac Dim-1 + antibiotic<br /> | **[[4zej]] - PsBlac Dim-1 + antibiotic<br /> | ||
| - | **[[2aio]] – StmBlac B + antibiotic<br /> | + | **[[2aio]], [[7a63]] – StmBlac B + antibiotic<br /> |
**[[5zge]], [[4ey2]], [[4eyb]], [[4eyf]], [[4efl]], [[4hl1]], [[4hl2]], [[4eyl]], [[4hky]], [[4ram]], [[4raw]], [[4rbs]], [[4rl0]], [[4rl2]], [[5of2]], [[5o2e]], ]], [[5o2f]], [[6jkb]] – KpBlac B Ndm-1+ antibiotic<br /> | **[[5zge]], [[4ey2]], [[4eyb]], [[4eyf]], [[4efl]], [[4hl1]], [[4hl2]], [[4eyl]], [[4hky]], [[4ram]], [[4raw]], [[4rbs]], [[4rl0]], [[4rl2]], [[5of2]], [[5o2e]], ]], [[5o2f]], [[6jkb]] – KpBlac B Ndm-1+ antibiotic<br /> | ||
**[[4rm5]] – KpBlac B Ndm-1 (mutant) + antibiotic<br /> | **[[4rm5]] – KpBlac B Ndm-1 (mutant) + antibiotic<br /> | ||
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**[[1jt1]] – FgBlac + captopril <br /> | **[[1jt1]] – FgBlac + captopril <br /> | ||
**[[1jje]], [[1jjt]], [[3lce]], [[3wxc]], [[4c1f]], [[4c1g]], [[5ndb]] - PaBlac B Imp-1+ inhibitor<br /> | **[[1jje]], [[1jjt]], [[3lce]], [[3wxc]], [[4c1f]], [[4c1g]], [[5ndb]] - PaBlac B Imp-1+ inhibitor<br /> | ||
| - | **[[5n5h]] - PaBlac B Vim-1 + inhibitor<br /> | + | **[[5n5h]], [[7afy]], [[7ayj]] - PaBlac B Vim-1 + inhibitor<br /> |
| - | **[[4c1d]], [[4c1e]], [[4pvo]], [[4pvt]], [[4ua4]], [[5lm6]], [[5le1]], [[5lch]], [[5lcf]], [[5lca]], [[5fqc]], [[5acx]], [[5acw]], [[5acv]], [[5acu]], [[5y6d]], [[5nhz]], [[5ni0]], [[5n4s]], [[5n4t]], [[5mxq]], [[5mxr]], [[5k48]], [[6hf5]], [[6ew3]], [[5y6e]], [[5o7n]], [[6dd0]], [[6dd1]], [[6j8r]], [[6kxo]], [[6kzn]], [[6sp7]], [[6v1p]], [[6zyn]], [[6zyo]], [[6zyp]] - PaBlac B Vim-2 + inhibitor<br /> | + | **[[4c1d]], [[4c1e]], [[4pvo]], [[4pvt]], [[4ua4]], [[5lm6]], [[5le1]], [[5lch]], [[5lcf]], [[5lca]], [[5fqc]], [[5acx]], [[5acw]], [[5acv]], [[5acu]], [[5y6d]], [[5nhz]], [[5ni0]], [[5n4s]], [[5n4t]], [[5mxq]], [[5mxr]], [[5k48]], [[6hf5]], [[6ew3]], [[5y6e]], [[5o7n]], [[6dd0]], [[6dd1]], [[6j8r]], [[6kxo]], [[6kzn]], [[6sp7]], [[6v1p]], [[6zyn]], [[6zyo]], [[6zyp]], [[7afx]], [[7chv]], [[7du1]]. [[7dub]], [[7due]], [[7duy]], [[7duz]], [[7dv1]], [[7dyy]], [[7dz0]], [[7dz1]] - PaBlac B Vim-2 + inhibitor<br /> |
**[[6ibs]], [[6ibv]], [[6jn6]], [[6o5t]], [[6rpn]] - PaBlac B Vim-2 + boronic acid inhibitor<br /> | **[[6ibs]], [[6ibv]], [[6jn6]], [[6o5t]], [[6rpn]] - PaBlac B Vim-2 + boronic acid inhibitor<br /> | ||
| + | **[[7a60]] - PaBlac B Vim-2 + antibiotic<br /> | ||
**[[5n55]], [[5n58]] - PaBlac B Vim-5 + inhibitor<br /> | **[[5n55]], [[5n58]] - PaBlac B Vim-5 + inhibitor<br /> | ||
**[[5mm9]] - PaBlac B Vim-17 + inhibitor<br /> | **[[5mm9]] - PaBlac B Vim-17 + inhibitor<br /> | ||
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**[[6k4t]], [[6k4x]] - SmBlac Smb-1+ inhibitor<br /> | **[[6k4t]], [[6k4x]] - SmBlac Smb-1+ inhibitor<br /> | ||
**[[2doo]] - SmBlac Imp-1+ fluorescent agent<br /> | **[[2doo]] - SmBlac Imp-1+ fluorescent agent<br /> | ||
| - | **[[2fu8]], [[2fu9]], [[2gfj]], [[2gfk]], [[2hb9]], [[2qdt]], [[5dpx]], [[5evk]], [[5evd]], [[5evb]], [[5hh6]], [[5hh5]] - StmBlac B L1 , [[6xbe]], [[6xbf]], [[6zyq]]+ inhibitor<br /> | + | **[[2fu8]], [[2fu9]], [[2gfj]], [[2gfk]], [[2hb9]], [[2qdt]], [[5dpx]], [[5evk]], [[5evd]], [[5evb]], [[5hh6]], [[5hh5]], [[7afz]] - StmBlac B L1 , [[6xbe]], [[6xbf]], [[6zyq]]+ inhibitor<br /> |
**[[3iof]], [[1x8i]], [[3iog]]– AhBlac B (mutant) + inhibitor<br /> | **[[3iof]], [[1x8i]], [[3iog]]– AhBlac B (mutant) + inhibitor<br /> | ||
**[[1x8g]], [[2gkl]], [[2qds]] – AhBlac B + inhibitor<br /> | **[[1x8g]], [[2gkl]], [[2qds]] – AhBlac B + inhibitor<br /> | ||
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**[[1zkj]], [[5f1f]], [[5k1d]], [[5gsc]] – EaBlac C – ''Enterobacter aerogenes''<br /> | **[[1zkj]], [[5f1f]], [[5k1d]], [[5gsc]] – EaBlac C – ''Enterobacter aerogenes''<br /> | ||
**[[2qz6]] – Blac C – ''Pseudomonas fluorescens''<br /> | **[[2qz6]] – Blac C – ''Pseudomonas fluorescens''<br /> | ||
| + | **[[7mqn]] – Blac C –'' Rhodobacter sphaeroides''<br /> | ||
**[[3w8k]], [[6k8x]], [[6m5p]] – KpBlac C<br /> | **[[3w8k]], [[6k8x]], [[6m5p]] – KpBlac C<br /> | ||
**[[6m5h]], [[6m5q]] – KpBlac C (mutant)<br /> | **[[6m5h]], [[6m5q]] – KpBlac C (mutant)<br /> | ||
| Line 349: | Line 359: | ||
**[[1g6a]] – PaBlac Pse-4 (mutant) <br /> | **[[1g6a]] – PaBlac Pse-4 (mutant) <br /> | ||
**[[1ko2]] – PaBlac Vim-2<br /> | **[[1ko2]] – PaBlac Vim-2<br /> | ||
| + | **[[7l5v]], [[7n1m]] - PaBlac D Oxa-935<br /> | ||
**[[1k38]] – Blac D – ''Salmonella typhimurium''<br /> | **[[1k38]] – Blac D – ''Salmonella typhimurium''<br /> | ||
**[[1m6k]] – EcBlac D<br /> | **[[1m6k]] – EcBlac D<br /> | ||
**[[3if6]], [[4s2p]] - KpBlac D Oxa-46<br /> | **[[3if6]], [[4s2p]] - KpBlac D Oxa-46<br /> | ||
| - | **[[3hbr]], [[6hoo]], [[7ass]] – KpBlac D Oxa-48<br /> | + | **[[3hbr]], [[6hoo]], [[7ass]], [[7lxg]] – KpBlac D Oxa-48<br /> |
**[[6i5d]], [[6rj7]] - KpBlac D Oxa-48 (mutant)<br /> | **[[6i5d]], [[6rj7]] - KpBlac D Oxa-48 (mutant)<br /> | ||
**[[6huh]] - KpBlac D Oxa-427<br /> | **[[6huh]] - KpBlac D Oxa-427<br /> | ||
| Line 370: | Line 381: | ||
**[[6n1n]] – Blac D – ''Sebaldella termitidis''<br /> | **[[6n1n]] – Blac D – ''Sebaldella termitidis''<br /> | ||
**[[6ue2]] – Blac D – ''Peptoclostridium difficile''<br /> | **[[6ue2]] – Blac D – ''Peptoclostridium difficile''<br /> | ||
| - | **[[6wy4]] – CdBlac D – ''Clostridium difficile''<br /> | + | **[[6wy4]], [[7rl8]] – CdBlac D – ''Clostridium difficile''<br /> |
| + | **[[7rlr]] – CdBlac D (mutant) <br /> | ||
**[[6w5g]] – BaBlac D – ''Bacillus atrophaeus''<br /> | **[[6w5g]] – BaBlac D – ''Bacillus atrophaeus''<br /> | ||
**[[6w5o]] – BaBlac D (mutant) <br /> | **[[6w5o]] – BaBlac D (mutant) <br /> | ||
| + | **[[7k3m]] – CpBlac D <br /> | ||
*β-lactamase class D binary complex | *β-lactamase class D binary complex | ||
| Line 380: | Line 393: | ||
**[[3isg]] – EcBlac D + inhibitor<br /> | **[[3isg]] – EcBlac D + inhibitor<br /> | ||
**[[4s2m]] - EncBlac D Oxa-163+ inhibitor<br /> | **[[4s2m]] - EncBlac D Oxa-163+ inhibitor<br /> | ||
| + | **[[7khy]], [[7khz]] - EncBlac D Oxa-163 (mutant) + drug<br /> | ||
**[[3pae]], [[3pag]], [[4f94]] - AbBlac D (mutant) + inhibitor <br /> | **[[3pae]], [[3pag]], [[4f94]] - AbBlac D (mutant) + inhibitor <br /> | ||
**[[3znt]], [[4y0u]], [[4y0t]] - AbBlac D + inhibitor<br /> | **[[3znt]], [[4y0u]], [[4y0t]] - AbBlac D + inhibitor<br /> | ||
**[[6mpq]], [[6b22]] - AbBlac D Oxa-24 + inhibitor<br /> | **[[6mpq]], [[6b22]] - AbBlac D Oxa-24 + inhibitor<br /> | ||
**[[5vfd]] - AbBlac D Oxa-24 (mutant) + inhibitor<br /> | **[[5vfd]] - AbBlac D Oxa-24 (mutant) + inhibitor<br /> | ||
| - | **[[5fat]], [[5fas]], [[5faq]], [[5fap]], [[5fao]], [[5dva]], [[5dtt]], [[5dts]], [[5dtk]], [[5qa4]], [[5qa5]], [[5qa6]], [[5qa7]], [[5qa8]], [[5qa9]], [[5qaa]], [[5qab]], [[5qac]], [[5qad]], [[5qae]], [[5qaf]], [[5qag]], [[5qah]], [[5qai]], [[5qaj]], [[5qak]], [[5qal]], [[5qam]], [[5qan]], [[5qao]], [[5qap]], [[5qaq]], [[5qar]], [[5qas]], [[5qat]], [[5qau]], [[5qav]], [[5qaw]], [[5qax]], [[5qay]], [[5qaz]], [[5qb0]], [[5qb1]], [[5qb2]], [[5qb3]], [[5qb4]], [[6uvk]], [[6v1o]] - KpBlac D Oxa-48 + inhibitor<br /> | + | **[[5fat]], [[5fas]], [[5faq]], [[5fap]], [[5fao]], [[5dva]], [[5dtt]], [[5dts]], [[5dtk]], [[5qa4]], [[5qa5]], [[5qa6]], [[5qa7]], [[5qa8]], [[5qa9]], [[5qaa]], [[5qab]], [[5qac]], [[5qad]], [[5qae]], [[5qaf]], [[5qag]], [[5qah]], [[5qai]], [[5qaj]], [[5qak]], [[5qal]], [[5qam]], [[5qan]], [[5qao]], [[5qap]], [[5qaq]], [[5qar]], [[5qas]], [[5qat]], [[5qau]], [[5qav]], [[5qaw]], [[5qax]], [[5qay]], [[5qaz]], [[5qb0]], [[5qb1]], [[5qb2]], [[5qb3]], [[5qb4]], [[6uvk]], [[6v1o]], [[7ass]], [[7aux]], [[7aw5]], [[7jhq]], [[7k5v]], [[7l8o]], [[7r6z]] - KpBlac D Oxa-48 + inhibitor<br /> |
*β-lactamase class D binary complex with antibiotics | *β-lactamase class D binary complex with antibiotics | ||
| - | **[[1k6r]], [[1k54]] - PaBlac D + antibiotic<br /> | + | **[[1k6r]], [[1k54]], [[7l5t]] - PaBlac D + antibiotic<br /> |
**[[2wgi]], [[2wkh]] - PaBlac D (mutant) + antibiotic<br /> | **[[2wgi]], [[2wkh]] - PaBlac D (mutant) + antibiotic<br /> | ||
**[[6n6x]], [[6n6y]], [[6n6v]], [[6n6u]] - AbBlac D Oxa-23 (mutant) + antibiotic<br /> | **[[6n6x]], [[6n6y]], [[6n6v]], [[6n6u]] - AbBlac D Oxa-23 (mutant) + antibiotic<br /> | ||
| + | **[[7rpg]], [[7rpe]], [[7rpf]] - AbBlac D Oxa-24 + antibiotic<br /> | ||
| + | **[[7rp8]], [[7rp9]], [[7rpa]], [[7rpb]], [[7rpc]], [[7rpd]] - AbBlac D Oxa-24 (mutant) + antibiotic<br /> | ||
**[[4x56]] - AbBlac D Oxa-160 + antibiotic<br /> | **[[4x56]] - AbBlac D Oxa-160 + antibiotic<br /> | ||
**[[4x53]] - AbBlac D Oxa-160 (mutant) + antibiotic<br /> | **[[4x53]] - AbBlac D Oxa-160 (mutant) + antibiotic<br /> | ||
**[[4x55]] - AbBlac D Oxa-225 (mutant) + antibiotic<br /> | **[[4x55]] - AbBlac D Oxa-225 (mutant) + antibiotic<br /> | ||
**[[4mll]] - KpBlac D Oxa-1 + antibiotic<br /> | **[[4mll]] - KpBlac D Oxa-1 + antibiotic<br /> | ||
| - | **[[4s2j]], [[4s2k]], [[4s2n]], [[4wmc]], [[6pqi]], [[6psg]], [[6pt1]], [[6pt5]], [[6ptu]] - KpBlac D Oxa-48 + antibiotic<br /> | + | **[[4s2j]], [[4s2k]], [[4s2n]], [[4wmc]], [[6pqi]], [[6psg]], [[6pt1]], [[6pt5]], [[6ptu]], [[7kh9]], [[7khq]] - KpBlac D Oxa-48 + antibiotic<br /> |
**[[6pxx]], [[7kh9]] - KpBlac D Oxa-48 (mutant) + antibiotic<br /> | **[[6pxx]], [[7kh9]] - KpBlac D Oxa-48 (mutant) + antibiotic<br /> | ||
**[[7khy]] - KpBlac D Oxa-163 + antibiotic<br /> | **[[7khy]] - KpBlac D Oxa-163 + antibiotic<br /> | ||
| Line 402: | Line 418: | ||
*'''AmpC β-lactamase''' | *'''AmpC β-lactamase''' | ||
| - | **[[1ke4]], [[2bls]], [[2zj9]], [[3bls]], [[5gzw]], [[6t3d]] – EcBlac<br /> | + | **[[1ke4]], [[2bls]], [[2zj9]], [[3bls]], [[5gzw]], [[6t3d]], [[7cin]] – EcBlac<br /> |
**[[1l0d]], [[1l0e]], [[1l0f]], [[1l0g]], [[4kg6]], [[5joc]] - EcBlac (mutant) | **[[1l0d]], [[1l0e]], [[1l0f]], [[1l0g]], [[4kg6]], [[5joc]] - EcBlac (mutant) | ||
**[[6lc7]] - EncBlac <br /> | **[[6lc7]] - EncBlac <br /> | ||
| Line 410: | Line 426: | ||
**[[5e2g]] – Blac – ''Burkholderia cenocepacia''<br /> | **[[5e2g]] – Blac – ''Burkholderia cenocepacia''<br /> | ||
| - | *AmpC -lactamase binary complex | + | *AmpC beta-lactamase binary complex |
**[[1fcn]] – EcBlac (mutant) + substrate<br /> | **[[1fcn]] – EcBlac (mutant) + substrate<br /> | ||
| Line 431: | Line 447: | ||
**[[3fai]], [[1x8h]], [[3sw3]], [[3t9m]] - AhBlac B (mutant)<br /> | **[[3fai]], [[1x8h]], [[3sw3]], [[3t9m]] - AhBlac B (mutant)<br /> | ||
**[[6p96]] - KpBlac Oxa-48 <br /> | **[[6p96]] - KpBlac Oxa-48 <br /> | ||
| + | **[[7o5t]], [[7o9n]], [[7peh]] - KpBlac D<br /> | ||
| + | **[[7pgo]] - KpBlac D (mutant)<br /> | ||
**[[3rxw]], [[3rxx]], [[2ov5]], [[5ul8]] – KpBlac Kpc-2 | **[[3rxw]], [[3rxx]], [[2ov5]], [[5ul8]] – KpBlac Kpc-2 | ||
| - | **[[6xd5]] - KpBlac Kpc-2 (mutant)<br /> | + | **[[6xd5]], [[7ljk]], [[7lk8]], [[7tb7]], [[7tbx]] - KpBlac Kpc-2 (mutant)<br /> |
**[[6qwd]] - KpBlac Kpc-3<br /> | **[[6qwd]] - KpBlac Kpc-3<br /> | ||
**[[6qwe]] - KpBlac Kpc-4<br /> | **[[6qwe]] - KpBlac Kpc-4<br /> | ||
| Line 449: | Line 467: | ||
**[[6p97]], [[6p98]], [[6p99]], [[6p9c]], [[6pk0]] - KpBlac Oxa-48 + antibiotic<br /> | **[[6p97]], [[6p98]], [[6p99]], [[6p9c]], [[6pk0]] - KpBlac Oxa-48 + antibiotic<br /> | ||
| + | **[[67dml]] - KpBlac Oxa-48 + inhibitor<br /> | ||
**[[3rxw]], [[3rxx]], [[2ov5]], [[5ul8]] – KpBlac Kpc<br /> | **[[3rxw]], [[3rxx]], [[2ov5]], [[5ul8]] – KpBlac Kpc<br /> | ||
**[[5eec]], [[6td1]] - KpBlac Kpc-2 + boronic acid inhibitor<br /> | **[[5eec]], [[6td1]] - KpBlac Kpc-2 + boronic acid inhibitor<br /> | ||
| - | **[[4zbe]], [[6b1y]], [[6b1x]], [[6b1w]], [[6b1j]], [[6b1h]], [[6b1f]], [[6d15]], [[6d16]], [[6d17]], [[6d18]], [[6d19]], [[6j8q]], [[6jn3]], [[6jn4]], [[6jn5]], [[6m7i]], [[6mey]], [[6mll]], [[6mnp]], [[6qw9]], [[6td0]], [[6v1j]] - KpBlac Kpc-2 + inhibitor<br /> | + | **[[4zbe]], [[6b1y]], [[6b1x]], [[6b1w]], [[6b1j]], [[6b1h]], [[6b1f]], [[6d15]], [[6d16]], [[6d17]], [[6d18]], [[6d19]], [[6j8q]], [[6jn3]], [[6jn4]], [[6jn5]], [[6m7i]], [[6mey]], [[6mll]], [[6mnp]], [[6qw9]], [[6td0]], [[6v1j]], [[7vqn]], [[7ti2]] - KpBlac Kpc-2 + inhibitor<br /> |
| - | **[[5uj3]], [[5uj4]], [[6v7i]], [[7a61]] - KpBlac Kpc-2 + antibiotic<br /> | + | **[[5uj3]], [[5uj4]], [[6v7i]], [[7a61]], [[7pep]], [[7tc1]] - KpBlac Kpc-2 + antibiotic<br /> |
| - | **[[6xd7]], [[6z23]], [[6z25]] - KpBlac Kpc-2 (mutant) + antibiotic<br /> | + | **[[6xd7]], [[6z23]], [[6z25]], [[7llb]], [[7llh]], [[7lnl]], [[7lr9]], [[7pse]], [[7psf]] - KpBlac Kpc-2 (mutant) + antibiotic<br /> |
**[[6qwa]] - KpBlac Kpc-3 + inhibitor<br /> | **[[6qwa]] - KpBlac Kpc-3 + inhibitor<br /> | ||
**[[6qwb]], [[6qwc]] - KpBlac Kpc-4 + inhibitor<br /> | **[[6qwb]], [[6qwc]] - KpBlac Kpc-4 + inhibitor<br /> | ||
| Line 476: | Line 495: | ||
**[[1fr1]], [[1fr6]] – CfBlac <br /> | **[[1fr1]], [[1fr6]] – CfBlac <br /> | ||
**[[1i2s]], [[4blm]] – BlBlac<br /> | **[[1i2s]], [[4blm]] – BlBlac<br /> | ||
| - | **[[2gdn]], [[3zhh]], [[5oyo]], [[5nj2]] – MtBlac – ''Mycobacterium tuberculosis''<br /> | + | **[[2gdn]], [[3zhh]], [[5oyo]], [[5nj2]], [[7k8l]] – MtBlac – ''Mycobacterium tuberculosis''<br /> |
**[[4whi]] – MtBlac C terminal<br /> | **[[4whi]] – MtBlac C terminal<br /> | ||
| - | **[[4jlf]], [[6h28]], [[6h27]] - MtBlac (mutant)<br /> | + | **[[4jlf]], [[6h28]], [[6h27]], [[7a5u]], [[7a5w]] - MtBlac (mutant)<br /> |
**[[2jc7]], [[3g4p]] – AbBlac <br /> | **[[2jc7]], [[3g4p]] – AbBlac <br /> | ||
**[[3byd]] – KoBlac <br /> | **[[3byd]] – KoBlac <br /> | ||
| Line 500: | Line 519: | ||
**[[5oe2]] – KpBlac Oxa-245 <br /> | **[[5oe2]] – KpBlac Oxa-245 <br /> | ||
**[[6gth]] – KpBlac <br /> | **[[6gth]] – KpBlac <br /> | ||
| + | **[[7oda]] – Blac Oxa-436 – ''Enterobacter asburiae'' <br /> | ||
**[[3wrt]] – ChBlac – ''Chromohalobacter''<br /> | **[[3wrt]] – ChBlac – ''Chromohalobacter''<br /> | ||
**[[3wrz]], [[3ws0]], [[3ws1]], [[3ws2]], [[3ws3]], [[3ws4]], [[3ws5]] – ChBlac (mutant)<br /> | **[[3wrz]], [[3ws0]], [[3ws1]], [[3ws2]], [[3ws3]], [[3ws4]], [[3ws5]] – ChBlac (mutant)<br /> | ||
| Line 507: | Line 527: | ||
**[[6mu9]] – Blac – ''Bacillus megaterium''<br /> | **[[6mu9]] – Blac – ''Bacillus megaterium''<br /> | ||
**[[6ch0]], [[6cgy]] – AaBlac – ''Alicyclobacillus acidoterrestris''<br /> | **[[6ch0]], [[6cgy]] – AaBlac – ''Alicyclobacillus acidoterrestris''<br /> | ||
| - | **[[6edm]] – CdBlac <br /> | + | **[[6edm]], [[7lno]], [[7lnr]], [[7me9]] – CdBlac <br /> |
**[[6izc]] – VpBlac – ''Vibrio parahaemolyticus''<br /> | **[[6izc]] – VpBlac – ''Vibrio parahaemolyticus''<br /> | ||
**[[6izd]] – VpBlac (mutant)<br /> | **[[6izd]] – VpBlac (mutant)<br /> | ||
| Line 523: | Line 543: | ||
**[[1ga0]] - EncBlac + inhibitor<br /> | **[[1ga0]] - EncBlac + inhibitor<br /> | ||
**[[1i2w]] – BlBlac + cifoxitin<br /> | **[[1i2w]] – BlBlac + cifoxitin<br /> | ||
| - | **[[3cg5]], [[4q8i]], [[4qb8]] – MtBlac + antibiotic<br /> | + | **[[3cg5]], [[4q8i]], [[4qb8]], [[7k8e]], [[7k8f]], [[7k8h]], [[7k8k]] – MtBlac + antibiotic<br /> |
**[[3n8s]], [[3ny4]], [[3n6i]], [[3n7w]], [[3n8l]], [[3n8r]], [[3nbl]], [[3nc8]], [[3nck]], [[3nde]], [[3ndg]] - MtBlac (mutant) + antibiotic<br /> | **[[3n8s]], [[3ny4]], [[3n6i]], [[3n7w]], [[3n8l]], [[3n8r]], [[3nbl]], [[3nc8]], [[3nck]], [[3nde]], [[3ndg]] - MtBlac (mutant) + antibiotic<br /> | ||
**[[3dwz]], [[3iqa]], [[3m6b]], [[3m6h]], [[4df6]], [[6h2k]], [[6h2i]], [[6h2h]], [[6h2g]], [[6h2c]] – MtBlac + inhibitor<br /> | **[[3dwz]], [[3iqa]], [[3m6b]], [[3m6h]], [[4df6]], [[6h2k]], [[6h2i]], [[6h2h]], [[6h2g]], [[6h2c]] – MtBlac + inhibitor<br /> | ||
| Line 534: | Line 554: | ||
**[[6uqs]], [[6uqt]], [[6uqu]], [[6ur3]] – PaBlac (mutant) + boronic acid inhibitor<br /> | **[[6uqs]], [[6uqt]], [[6uqu]], [[6ur3]] – PaBlac (mutant) + boronic acid inhibitor<br /> | ||
**[[6cgz]] – AaBlac + lactone derivative<br /> | **[[6cgz]] – AaBlac + lactone derivative<br /> | ||
| + | **[[7kep]], [[7keq]], [[7ker]], [[7lnq]], [[7mea]], [[7meb]], [[7mec]], [[7med]], [[7mee]], [[7mef]], [[7meg]], [[7meh]] – CdBlac + drug<br /> | ||
**[[6pqc]] – CdBlac (mutant) + antibiotic <br /> | **[[6pqc]] – CdBlac (mutant) + antibiotic <br /> | ||
**[[7doo]] – BmBlac + antibiotic <br /> | **[[7doo]] – BmBlac + antibiotic <br /> | ||
| + | **[[7ddm]] – BmBlac + peptide <br /> | ||
| + | |||
| + | *Serine beta-lactamase (ClbP) | ||
| + | |||
| + | **[[7mde]], [[7mdf]] – EcClbP (mutant)<br /> | ||
| + | **[[7ul6]] – EcClbP – Cryo EM <br /> | ||
| + | **[[3o3v]] – EcClbP peptidase domain 38-372<br /> | ||
| + | **[[4e6w]], [[4e6x]], [[7mdc]] – EcClbP + boronic acid inhibitor<br /> | ||
| + | |||
}} | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
3D Structures of Beta-lactamase
Updated on 30-May-2024
