5qu1

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:28, 21 February 2024) (edit) (undo)
 
(One intermediate revision not shown.)
Line 3: Line 3:
<StructureSection load='5qu1' size='340' side='right'caption='[[5qu1]], [[Resolution|resolution]] 1.08&Aring;' scene=''>
<StructureSection load='5qu1' size='340' side='right'caption='[[5qu1]], [[Resolution|resolution]] 1.08&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5qu1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QU1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QU1 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5qu1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QU1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QU1 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.08&#8491;</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NCK1, NCK ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qu1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qu1 OCA], [https://pdbe.org/5qu1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qu1 RCSB], [https://www.ebi.ac.uk/pdbsum/5qu1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qu1 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qu1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qu1 OCA], [https://pdbe.org/5qu1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qu1 RCSB], [https://www.ebi.ac.uk/pdbsum/5qu1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qu1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[https://www.uniprot.org/uniprot/NCK1_HUMAN NCK1_HUMAN]] Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.<ref>PMID:10026169</ref> <ref>PMID:16835242</ref> <ref>PMID:17803907</ref>
+
[https://www.uniprot.org/uniprot/NCK1_HUMAN NCK1_HUMAN] Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.<ref>PMID:10026169</ref> <ref>PMID:16835242</ref> <ref>PMID:17803907</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Human]]
+
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
-
[[Category: Benz, J]]
+
[[Category: Benz J]]
-
[[Category: Burger, D]]
+
[[Category: Burger D]]
-
[[Category: Rudolph, M G]]
+
[[Category: Rudolph MG]]
-
[[Category: Ruf, A]]
+
[[Category: Ruf A]]
-
[[Category: Schlatter, D]]
+
[[Category: Schlatter D]]
-
[[Category: Adaptor]]
+
-
[[Category: Domain swap]]
+
-
[[Category: Peptide binding]]
+
-
[[Category: Sh3 domain]]
+
-
[[Category: Signaling protein]]
+

Current revision

Crystal Structure of the monomeric human Nck SH3.1 domain, triclinic, 1.08A

PDB ID 5qu1

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5qu1"
Personal tools