5qu6
From Proteopedia
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<StructureSection load='5qu6' size='340' side='right'caption='[[5qu6]], [[Resolution|resolution]] 1.82Å' scene=''> | <StructureSection load='5qu6' size='340' side='right'caption='[[5qu6]], [[Resolution|resolution]] 1.82Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5qu6]] is a 28 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[5qu6]] is a 28 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QU6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QU6 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.816Å</td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qu6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qu6 OCA], [https://pdbe.org/5qu6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qu6 RCSB], [https://www.ebi.ac.uk/pdbsum/5qu6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qu6 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qu6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qu6 OCA], [https://pdbe.org/5qu6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qu6 RCSB], [https://www.ebi.ac.uk/pdbsum/5qu6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qu6 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/NCK1_HUMAN NCK1_HUMAN] Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling.<ref>PMID:10026169</ref> <ref>PMID:16835242</ref> <ref>PMID:17803907</ref> | |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Rudolph | + | [[Category: Rudolph MG]] |
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Current revision
Crystal Structure of swapped human Nck SH3.1 domain, 1.8A, triclinic
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