2lez

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==Solution NMR structure of N-terminal domain of Salmonella effector protein PipB2. Northeast structural genomics consortium (NESG) target stt318a==
==Solution NMR structure of N-terminal domain of Salmonella effector protein PipB2. Northeast structural genomics consortium (NESG) target stt318a==
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<StructureSection load='2lez' size='340' side='right'caption='[[2lez]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2lez' size='340' side='right'caption='[[2lez]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2lez]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_typhimurium"_loeffler_1892 "bacillus typhimurium" loeffler 1892]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LEZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LEZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2lez]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LEZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LEZ FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pipB2, STM2780 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=90371 "Bacillus typhimurium" Loeffler 1892])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lez FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lez OCA], [https://pdbe.org/2lez PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lez RCSB], [https://www.ebi.ac.uk/pdbsum/2lez PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lez ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lez FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lez OCA], [https://pdbe.org/2lez PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lez RCSB], [https://www.ebi.ac.uk/pdbsum/2lez PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lez ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PIPB2_SALTY PIPB2_SALTY]] Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. Involved in the reorganization of late endosome/lysosome (LE/Lys) compartments in mammalian cells. Necessary and sufficient to link kinesin-1 onto the Salmonella-containing vacuole (SCV) membrane. Required for centrifugal extension of lysosomal glycoprotein-rich membrane tubules, known as Salmonella-induced filaments (Sifs), away from the SCV and toward the cell periphery. Required for virulence, but not for intracellular survival and replication in phagocytic cells.<ref>PMID:12864852</ref> <ref>PMID:15987736</ref> <ref>PMID:16938850</ref>
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[https://www.uniprot.org/uniprot/PIPB2_SALTY PIPB2_SALTY] Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. Involved in the reorganization of late endosome/lysosome (LE/Lys) compartments in mammalian cells. Necessary and sufficient to link kinesin-1 onto the Salmonella-containing vacuole (SCV) membrane. Required for centrifugal extension of lysosomal glycoprotein-rich membrane tubules, known as Salmonella-induced filaments (Sifs), away from the SCV and toward the cell periphery. Required for virulence, but not for intracellular survival and replication in phagocytic cells.<ref>PMID:12864852</ref> <ref>PMID:15987736</ref> <ref>PMID:16938850</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus typhimurium loeffler 1892]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arrowsmith, C]]
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[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
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[[Category: Daniels, C]]
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[[Category: Arrowsmith C]]
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[[Category: Garcia, M]]
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[[Category: Daniels C]]
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[[Category: Houliston, S]]
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[[Category: Garcia M]]
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[[Category: Lemak, A]]
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[[Category: Houliston S]]
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[[Category: Montelione, G T]]
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[[Category: Lemak A]]
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[[Category: Structural genomic]]
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[[Category: Montelione GT]]
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[[Category: Savchenko, A]]
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[[Category: Savchenko A]]
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[[Category: Yee, A]]
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[[Category: Yee A]]
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[[Category: Bacterial effector]]
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[[Category: Nesg]]
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[[Category: Psi-biology]]
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[[Category: Signaling protein]]
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[[Category: Virulence factor]]
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Current revision

Solution NMR structure of N-terminal domain of Salmonella effector protein PipB2. Northeast structural genomics consortium (NESG) target stt318a

PDB ID 2lez

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