2ljq

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==(C9S, C14S)-leucocin A==
==(C9S, C14S)-leucocin A==
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<StructureSection load='2ljq' size='340' side='right'caption='[[2ljq]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2ljq' size='340' side='right'caption='[[2ljq]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2ljq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_49366 Atcc 49366]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LJQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2ljq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leuconostoc_gelidum Leuconostoc gelidum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LJQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LJQ FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2ljt|2ljt]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lcnA ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1244 ATCC 49366])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ljq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ljq OCA], [https://pdbe.org/2ljq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ljq RCSB], [https://www.ebi.ac.uk/pdbsum/2ljq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ljq ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ljq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ljq OCA], [https://pdbe.org/2ljq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ljq RCSB], [https://www.ebi.ac.uk/pdbsum/2ljq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ljq ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/LCCA_LEUGE LCCA_LEUGE]] Inhibits a wide spectrum of lactic acid bacteria.
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[https://www.uniprot.org/uniprot/LCCA_LEUGE LCCA_LEUGE] Inhibits a wide spectrum of lactic acid bacteria.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Bridge not required: The disulfide bridge in the antibacterial peptide leucocin A was replaced with two Ser or two Leu residues. The double leucine mutant was found to be active, and elucidation of its 3D structure showed that the two leucines interact to hold the N- and C-terminal domains together.
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Substitution of a Conserved Disulfide in the Type IIa Bacteriocin, Leucocin A, with L-Leucine and L-Serine Residues: Effects on Activity and Three-Dimensional Structure.,Sit CS, Lohans CT, van Belkum MJ, Campbell CD, Miskolzie M, Vederas JC Chembiochem. 2012 Jan 2;13(1):35-8. doi: 10.1002/cbic.201100634. Epub 2011, Nov 25. PMID:22121114<ref>PMID:22121114</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2ljq" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Atcc 49366]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Belkum, M J.van]]
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[[Category: Leuconostoc gelidum]]
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[[Category: Campbell, C D]]
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[[Category: Campbell CD]]
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[[Category: Lohans, C T]]
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[[Category: Lohans CT]]
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[[Category: Miskolzie, M]]
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[[Category: Miskolzie M]]
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[[Category: Sit, C S]]
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[[Category: Sit CS]]
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[[Category: Vederas, J C]]
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[[Category: Vederas JC]]
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[[Category: Alpha helix]]
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[[Category: Van Belkum MJ]]
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[[Category: Antimicrobial protein]]
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Current revision

(C9S, C14S)-leucocin A

PDB ID 2ljq

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