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2lms

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Current revision (11:08, 15 February 2023) (edit) (undo)
 
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==A single GalNAc residue on Threonine-106 modifies the dynamics and the structure of Interferon alpha-2a around the glycosylation site==
==A single GalNAc residue on Threonine-106 modifies the dynamics and the structure of Interferon alpha-2a around the glycosylation site==
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<StructureSection load='2lms' size='340' side='right'caption='[[2lms]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2lms' size='340' side='right'caption='[[2lms]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2lms]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LMS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LMS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2lms]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LMS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LMS FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IFNA2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lms FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lms OCA], [https://pdbe.org/2lms PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lms RCSB], [https://www.ebi.ac.uk/pdbsum/2lms PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lms ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lms FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lms OCA], [https://pdbe.org/2lms PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lms RCSB], [https://www.ebi.ac.uk/pdbsum/2lms PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lms ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/IFNA2_HUMAN IFNA2_HUMAN]] Produced by macrophages, IFN-alpha have antiviral activities.
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[https://www.uniprot.org/uniprot/IFNA2_HUMAN IFNA2_HUMAN] Produced by macrophages, IFN-alpha have antiviral activities.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Aubin, Y]]
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[[Category: Aubin Y]]
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[[Category: Belcourt, P J.F]]
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[[Category: Belcourt PJF]]
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[[Category: Brochu, D]]
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[[Category: Brochu D]]
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[[Category: Ghasriani, H]]
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[[Category: Ghasriani H]]
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[[Category: Gilbert, M]]
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[[Category: Gilbert M]]
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[[Category: Gingras, G]]
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[[Category: Gingras G]]
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[[Category: Hodgson, D J]]
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[[Category: Hodgson DJ]]
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[[Category: Sauve, S]]
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[[Category: Sauve S]]
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[[Category: Cytokine]]
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[[Category: Glycoprotein]]
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[[Category: Immune system]]
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[[Category: O-glycosylation]]
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[[Category: Signaling protein]]
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[[Category: Type i interferon]]
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Current revision

A single GalNAc residue on Threonine-106 modifies the dynamics and the structure of Interferon alpha-2a around the glycosylation site

PDB ID 2lms

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