LDL receptor
From Proteopedia
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== Function == | == Function == | ||
'''LDL (Low Density Lipoprotein) receptor''' (LDLR) mediates the endocytosis of cholesterol-rich LDL. LDLR recognizes the apoprotein B100 which is embedded in the outer layer of the LDL particle. LDLR sits on the cell surface and binds LDL particles which circulate in the blood stream. LDLR transports the LDL particle into the cell where the cholesterol is used. Upon release of the LDL particle, the LDLR is recycled back into the cell membrane surface<ref>PMID:19299327</ref>. | '''LDL (Low Density Lipoprotein) receptor''' (LDLR) mediates the endocytosis of cholesterol-rich LDL. LDLR recognizes the apoprotein B100 which is embedded in the outer layer of the LDL particle. LDLR sits on the cell surface and binds LDL particles which circulate in the blood stream. LDLR transports the LDL particle into the cell where the cholesterol is used. Upon release of the LDL particle, the LDLR is recycled back into the cell membrane surface<ref>PMID:19299327</ref>. | ||
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| + | See also [[Transmembrane (cell surface) receptors]] | ||
== Disease == | == Disease == | ||
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{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| - | *hLDLR ligand-binding domain | + | *hLDLR ligand-binding domain;Repeats - LB1 20-67; LB2 55-104; LB4 144-195; LB5 196-232; LB6 234-272; LB7 274-313 |
**[[1ldl]] – hLDLR LB1 - human - NMR<br /> | **[[1ldl]] – hLDLR LB1 - human - NMR<br /> | ||
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**[[5oy9]] – hLDLR LBD LB3 + glycoprotein G<br /> | **[[5oy9]] – hLDLR LBD LB3 + glycoprotein G<br /> | ||
| - | *hLDLR EGFP | + | *hLDLR EGFP domain 263-699 |
**[[1ijq]] – hLDLR YWTD-EGF<br /> | **[[1ijq]] – hLDLR YWTD-EGF<br /> | ||
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**[[2w2n]], [[3gcw]] – hLDLR EGF1, EGF2 (mutant) + proprotein convertase subtilisin/kexin 9<br /> | **[[2w2n]], [[3gcw]] – hLDLR EGF1, EGF2 (mutant) + proprotein convertase subtilisin/kexin 9<br /> | ||
| - | *hLDLR cytoplasmic domain | + | *hLDLR cytoplasmic domain C terminal 817-832 |
**[[3so6]] – hLDLR C terminal + LDLR adaptor protein<br /> | **[[3so6]] – hLDLR C terminal + LDLR adaptor protein<br /> | ||
| - | *hLDLR lectin-like domain | + | *hLDLR lectin-like domain 136-273 |
| + | **[[1ypo]], [[1ypq]], [[1ypu]], [[7w5d]], [[7xmp]] – hLDLR<br /> | ||
**[[3vlg]] – hLDLR (mutant)<br /> | **[[3vlg]] – hLDLR (mutant)<br /> | ||
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| + | *hLDLR Cys-rich domain 70-190 | ||
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| + | **[[6byv]] – hLDLR - NMR<br /> | ||
*hLDLR multiple domains | *hLDLR multiple domains | ||
Current revision
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3D structures of LDL receptor
Updated on 10-July-2024
References
- ↑ Goldstein JL, Brown MS. The LDL receptor. Arterioscler Thromb Vasc Biol. 2009 Apr;29(4):431-8. doi:, 10.1161/ATVBAHA.108.179564. PMID:19299327 doi:http://dx.doi.org/10.1161/ATVBAHA.108.179564
- ↑ Mak YT, Pang CP, Tomlinson B, Zhang J, Chan YS, Mak TW, Masarei JR. Mutations in the low-density lipoprotein receptor gene in Chinese familial hypercholesterolemia patients. Arterioscler Thromb Vasc Biol. 1998 Oct;18(10):1600-5. PMID:9763532
