6zmq
From Proteopedia
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==Cytochrome c Heme Lyase CcmF== | ==Cytochrome c Heme Lyase CcmF== | ||
| - | <StructureSection load='6zmq' size='340' side='right'caption='[[6zmq]]' scene=''> | + | <StructureSection load='6zmq' size='340' side='right'caption='[[6zmq]], [[Resolution|resolution]] 2.67Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZMQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZMQ FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6zmq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thet2 Thet2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZMQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZMQ FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zmq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zmq OCA], [https://pdbe.org/6zmq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zmq RCSB], [https://www.ebi.ac.uk/pdbsum/6zmq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zmq ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=PTY:PHOSPHATIDYLETHANOLAMINE'>PTY</scene></td></tr> |
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ccmF, TT_C1038 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=262724 THET2])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zmq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zmq OCA], [https://pdbe.org/6zmq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zmq RCSB], [https://www.ebi.ac.uk/pdbsum/6zmq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zmq ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The covalent attachment of one or multiple heme cofactors to cytochrome c protein chains enables cytochrome c proteins to be used in electron transfer and redox catalysis in extracytoplasmic environments. A dedicated heme maturation machinery, whose core component is a heme lyase, scans nascent peptides after Sec-dependent translocation for CXnCH-binding motifs. Here we report the three-dimensional (3D) structure of the heme lyase CcmF, a 643-amino acid integral membrane protein, from Thermus thermophilus. CcmF contains a heme b cofactor at the bottom of a large cavity that opens toward the extracellular side to receive heme groups from the heme chaperone CcmE for cytochrome maturation. A surface groove on CcmF may guide the extended apoprotein to heme attachment at or near a loop containing the functionally essential WXWD motif, which is situated above the putative cofactor binding pocket. The structure suggests heme delivery from within the membrane, redefining the role of the chaperone CcmE. | ||
| + | |||
| + | Architecture of the membrane-bound cytochrome c heme lyase CcmF.,Brausemann A, Zhang L, Ilcu L, Einsle O Nat Chem Biol. 2021 May 6. pii: 10.1038/s41589-021-00793-8. doi:, 10.1038/s41589-021-00793-8. PMID:33958791<ref>PMID:33958791</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6zmq" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Brausemann A]] | + | [[Category: Thet2]] |
| - | [[Category: Einsle O]] | + | [[Category: Brausemann, A]] |
| + | [[Category: Einsle, O]] | ||
| + | [[Category: Heme lyase cytochrome c maturation membrane protein cytochrome]] | ||
| + | [[Category: Membrane protein]] | ||
Current revision
Cytochrome c Heme Lyase CcmF
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