7c4o
From Proteopedia
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<StructureSection load='7c4o' size='340' side='right'caption='[[7c4o]]' scene=''> | <StructureSection load='7c4o' size='340' side='right'caption='[[7c4o]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full | + | <table><tr><td colspan='2'>[[7c4o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7C4O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7C4O FirstGlance]. <br> |
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7c4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c4o OCA], [https://pdbe.org/7c4o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7c4o RCSB], [https://www.ebi.ac.uk/pdbsum/7c4o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7c4o ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7c4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c4o OCA], [https://pdbe.org/7c4o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7c4o RCSB], [https://www.ebi.ac.uk/pdbsum/7c4o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7c4o ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HES1_HUMAN HES1_HUMAN] Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.<ref>PMID:18550849</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Fan JS]] | [[Category: Fan JS]] | ||
[[Category: Nayak A]] | [[Category: Nayak A]] | ||
[[Category: Swaminathan K]] | [[Category: Swaminathan K]] | ||
Current revision
Solution structure of the Orange domain from human protein HES1
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