6yw8

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==NMR solution structure of unbound recombinant human Nerve Growth Factor (rhNGF)==
==NMR solution structure of unbound recombinant human Nerve Growth Factor (rhNGF)==
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<StructureSection load='6yw8' size='340' side='right'caption='[[6yw8]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='6yw8' size='340' side='right'caption='[[6yw8]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6yw8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YW8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YW8 FirstGlance]. <br>
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<table><tr><td colspan='2'>Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YW8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YW8 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NGF, NGFB ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6yw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yw8 OCA], [https://pdbe.org/6yw8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6yw8 RCSB], [https://www.ebi.ac.uk/pdbsum/6yw8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6yw8 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6yw8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yw8 OCA], [https://pdbe.org/6yw8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6yw8 RCSB], [https://www.ebi.ac.uk/pdbsum/6yw8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6yw8 ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
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[[https://www.uniprot.org/uniprot/NGF_HUMAN NGF_HUMAN]] Defects in NGF are the cause of hereditary sensory and autonomic neuropathy type 5 (HSAN5) [MIM:[https://omim.org/entry/608654 608654]]. The hereditary sensory and autonomic neuropathies are a genetically and clinically heterogeneous group of disorders characterized by degeneration of dorsal root and autonomic ganglion cells, and by sensory and/or autonomic abnormalities. HSAN5 patients manifest loss of pain perception and impaired temperature sensitivity, ulcers, and in some cases self-mutilation. The autonomic involvement is variable.<ref>PMID:14976160</ref> <ref>PMID:20978020</ref> <ref>PMID:22302274</ref>
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==See Also==
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== Function ==
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*[[Nerve growth factor|Nerve growth factor]]
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[[https://www.uniprot.org/uniprot/NGF_HUMAN NGF_HUMAN]] Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival.
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Grdadolnik, S Golic]]
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[[Category: Golic Grdadolnik S]]
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[[Category: Paoletti, F]]
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[[Category: Paoletti F]]
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[[Category: Cystin-knot]]
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[[Category: Homodimer]]
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[[Category: Hormone]]
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[[Category: Human ngf]]
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[[Category: Unbound structure]]
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Current revision

NMR solution structure of unbound recombinant human Nerve Growth Factor (rhNGF)

PDB ID 6yw8

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