16vp
From Proteopedia
(Difference between revisions)
Line 3: | Line 3: | ||
<StructureSection load='16vp' size='340' side='right'caption='[[16vp]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='16vp' size='340' side='right'caption='[[16vp]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[16vp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[16vp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1 Human alphaherpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=16VP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=16VP FirstGlance]. <br> |
- | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> |
+ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=16vp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=16vp OCA], [https://pdbe.org/16vp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=16vp RCSB], [https://www.ebi.ac.uk/pdbsum/16vp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=16vp ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=16vp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=16vp OCA], [https://pdbe.org/16vp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=16vp RCSB], [https://www.ebi.ac.uk/pdbsum/16vp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=16vp ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
- | + | [https://www.uniprot.org/uniprot/VP16_HHV11 VP16_HHV11] Transcriptional activator of immediate-early (IE) gene products (alpha genes). Acts as a key activator of lytic infection by initiating the lytic program through the assembly of the transcriptional regulatory VP16-induced complex composed of VP16 and two cellular factors, HCFC1 and POU2F 1. VP16-induced complex represents a regulatory switch: when it is on, it promotes IE-gene expression and thus lytic infection, and when it is off, it limits IE-gene transcription favoring latent infection. May play a role in the aggregation of tegument proteins around nucleocapsids during virus morphogenesis. | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Line 32: | Line 33: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
- | [[Category: | + | [[Category: Human alphaherpesvirus 1]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
- | [[Category: Cheng | + | [[Category: Cheng X]] |
- | [[Category: Gong | + | [[Category: Gong W]] |
- | [[Category: Herr | + | [[Category: Herr W]] |
- | [[Category: Huang | + | [[Category: Huang CC]] |
- | [[Category: Liu | + | [[Category: Liu Y]] |
- | + |
Current revision
CONSERVED CORE OF THE HERPES SIMPLEX VIRUS TRANSCRIPTIONAL REGULATORY PROTEIN VP16
|