2lu3
From Proteopedia
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==Solution NMR structure of the apo-form of the beta2 carbohydrate module of AMP-activated protein kinase== | ==Solution NMR structure of the apo-form of the beta2 carbohydrate module of AMP-activated protein kinase== | ||
| - | <StructureSection load='2lu3' size='340' side='right'caption='[[2lu3 | + | <StructureSection load='2lu3' size='340' side='right'caption='[[2lu3]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2lu3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2lu3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LU3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LU3 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lu3 OCA], [https://pdbe.org/2lu3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lu3 RCSB], [https://www.ebi.ac.uk/pdbsum/2lu3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lu3 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lu3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lu3 OCA], [https://pdbe.org/2lu3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lu3 RCSB], [https://www.ebi.ac.uk/pdbsum/2lu3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lu3 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/AAKB2_RAT AAKB2_RAT] Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3) (By similarity). | |
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Buffalo rat]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Rattus norvegicus]] |
| - | [[Category: | + | [[Category: Gooley P]] |
| - | [[Category: | + | [[Category: Koay A]] |
| - | [[Category: | + | [[Category: Stapleton D]] |
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Current revision
Solution NMR structure of the apo-form of the beta2 carbohydrate module of AMP-activated protein kinase
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