2luw

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==Solution structure of vEP C-ter 100==
==Solution structure of vEP C-ter 100==
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<StructureSection load='2luw' size='340' side='right'caption='[[2luw]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2luw' size='340' side='right'caption='[[2luw]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2luw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_27562 Atcc 27562]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LUW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LUW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2luw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_vulnificus Vibrio vulnificus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LUW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LUW FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">vvp ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=672 ATCC 27562])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2luw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2luw OCA], [https://pdbe.org/2luw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2luw RCSB], [https://www.ebi.ac.uk/pdbsum/2luw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2luw ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2luw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2luw OCA], [https://pdbe.org/2luw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2luw RCSB], [https://www.ebi.ac.uk/pdbsum/2luw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2luw ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q06AK2_VIBVL Q06AK2_VIBVL]
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Calicheamicin gamma1I (1) is an enediyne antitumor compound produced by Micromonospora echinospora spp. calichensis, and its biosynthetic gene cluster has been previously reported. Despite extensive analysis and biochemical study, several genes in the biosynthetic gene cluster of 1 remain functionally unassigned. Using a structural genomics approach and biochemical characterization, two proteins encoded by genes from the 1 biosynthetic gene cluster assigned as "unknowns", CalU16 and CalU19, were characterized. Structure analysis revealed that they possess the STeroidogenic Acute Regulatory protein related lipid Transfer (START) domain known mainly to bind and transport lipids and previously identified as the structural signature of the enediyne self-resistance protein CalC. Subsequent study revealed calU16 and calU19 to confer resistance to 1, and reminiscent of the prototype CalC, both CalU16 and CalU19 were cleaved by 1 in vitro. Through site-directed mutagenesis and mass spectrometry, we identified the site of cleavage in each protein and characterized their function in conferring resistance against 1. This report emphasizes the importance of structural genomics as a powerful tool for the functional annotation of unknown proteins.
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Structure-Guided Functional Characterization of Enediyne Self-Sacrifice Resistance Proteins, CalU16 and CalU19.,Elshahawi SI, Ramelot TA, Seetharaman J, Chen J, Singh S, Yang Y, Pederson K, Kharel MK, Xiao R, Lew S, Yennamalli RM, Miller MD, Wang F, Tong L, Montelione GT, Kennedy MA, Bingman CA, Zhu H, Phillips GN Jr, Thorson JS ACS Chem Biol. 2014 Aug 13. PMID:25079510<ref>PMID:25079510</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2luw" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Atcc 27562]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lee, W]]
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[[Category: Vibrio vulnificus]]
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[[Category: Yun, J]]
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[[Category: Lee W]]
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[[Category: Anti-parallel beta-sheet]]
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[[Category: Yun J]]
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[[Category: Hydrolase]]
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Current revision

Solution structure of vEP C-ter 100

PDB ID 2luw

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